An endogenous opioid peptide derived from BETA-LIPOTROPIN of the pro-opiomelanocortin (POMC) system. It is the 16-amino acid sequence of the N-terminal of BETA-ENDORPHIN and differs from GAMMA-ENDORPHIN by one amino acid (beta-endorphin 1-17).
CAT No: R1904
CAS No:61512-76-3/59004-96-5
Synonyms/Alias:alpha-ENDORPHIN;59004-96-5;Endorphin, alpha;Lipotropin 61-76;61512-76-3;YGGFMTSEKS QTPLVT;|A-Endorphin human;alpha Endorphin;alpha -Endorphin;-Endorphin (human);alpha-Endorphin, human;|A-Endorphin (human);beta-Endorphin (1-16);CHEMBL255300;HY-P1253;MFCD00076381;AKOS037645059;LPH(61-76);alpha-Endorphin human, >=97% (HPLC);AS-56652;FE108746;PD077135;G77856;Q4734927;
Chemical Name:(4S)-5-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S,3R)-1-[(2S)-2-[[(2S)-1-[[(2S)-1-[[(1S,2R)-1-carboxy-2-hydroxypropyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-3-hydroxy-1-oxobutan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]amino]-4-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylsulfanylbutanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoic acid
Alpha-Endorphin is a naturally occurring endogenous peptide that belongs to the endorphin family, a group of neuropeptides renowned for their role in modulating pain and emotion within the central nervous system. Structurally, alpha-endorphin is derived from the precursor protein pro-opiomelanocortin (POMC) and consists of a specific amino acid sequence that confers unique biological activity distinct from other endorphins. Its functional significance is underscored by its involvement in neurochemical signaling pathways that influence mood, stress response, and behavioral processes. As a research peptide, alpha-endorphin is a valuable tool for elucidating the molecular mechanisms underlying neuropeptide function and for advancing the understanding of peptide-mediated signaling in physiological and pathological contexts.
Neuropharmacology research: Alpha-endorphin serves as a model compound for investigating the pharmacodynamics of endogenous opioid peptides in the brain. Researchers utilize this peptide to study receptor binding affinities, signal transduction pathways, and the downstream effects of neuropeptide-receptor interactions. Such studies are critical for delineating the specific roles of individual endorphins in modulating neurotransmitter release and synaptic plasticity, thereby contributing to a nuanced understanding of neuropharmacological mechanisms.
Behavioral neuroscience studies: The peptide is frequently employed in experimental paradigms designed to assess its influence on mood, motivation, and stress-related behaviors in animal models. By administering alpha-endorphin and observing resultant behavioral changes, scientists can explore the peptide's impact on reward processing, anxiety modulation, and adaptive responses to environmental stimuli. These investigations provide foundational insights into the neurobiological substrates of affective and behavioral regulation.
Receptor mapping and binding assays: Alpha-endorphin is instrumental in receptor localization and characterization studies, particularly concerning opioid receptor subtypes such as mu, delta, and kappa. Through radioligand binding assays and advanced imaging techniques, the peptide enables precise mapping of receptor distribution and density in neural tissues. This application is vital for clarifying the differential effects of various endorphins and for identifying potential targets for neuromodulatory interventions.
Peptide structure-activity relationship (SAR) analysis: The unique sequence and structural features of alpha-endorphin make it an excellent candidate for SAR studies, which aim to correlate specific amino acid residues with biological activity. Researchers synthesize analogs and truncated forms of the peptide to systematically evaluate how modifications influence receptor interaction, stability, and functional efficacy. Such analyses are essential for the rational design of novel peptide-based modulators with tailored pharmacological profiles.
Analytical method development: In the context of bioanalytical chemistry, alpha-endorphin is utilized as a reference standard or calibration compound in the development and validation of quantitative assays. Techniques such as liquid chromatography-mass spectrometry (LC-MS) and immunoassays rely on high-quality peptide standards to achieve accurate detection and quantification of endogenous neuropeptides in complex biological matrices. This application supports robust measurement of peptide concentrations in research samples, facilitating reliable data generation in neurochemical studies.
2. Urinary Metabolites Associated with Blood Pressure on a Low-or High-Sodium Die
5. Cationic cell-penetrating peptides are potent furin inhibitors
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