3-Amino-DL-tyrosine dihydrochloride monohydrate is a free amino acid derivative classified in the tyrosine family, featuring a phenolic aromatic side chain and both an amino group and a carboxyl group on the alpha carbon in a DL (racemic) mixture. The molecule is present as a dihydrochloride salt with an additional monohydrate, so the amino and carboxyl functionalities are protonated/ion-paired with chloride while retaining the phenolic hydroxyl on the side chain as a hydrogen-bonding and derivatizable handle. In peptide chemistry and chemical biology workflows, this salt form is used as a defined tyrosine building block for incorporating the phenolic side chain into synthetic sequences or for preparing labeled and conjugatable tyrosine-containing intermediates under conditions that require controlled solubility and handling of the amino acid.
CAT No: CP17503
3-Amino-DL-tyrosine dihydrochloride monohydrate is an amino acid derivative based on the tyrosine scaffold in a DL stereochemical mixture, supplied as a dihydrochloride monohydrate salt to enhance handling and water compatibility. The molecule retains the phenolic side chain characteristic of tyrosine while presenting an additional amino functionality at the 3-position, making it a useful building block for introducing extra nitrogen content into peptide-like structures and heterocycle precursors. In research and development workflows, this salt form is commonly selected when controlled, reproducible dosing and improved solubility are required for downstream coupling chemistry or analytical standard preparation.
1. Modified Peptide Building Blocks
3-Amino-DL-tyrosine dihydrochloride monohydrate is used as a specialized amino acid building block for preparing modified peptides and peptide analogs where incorporation of an extra amino group is desired alongside the tyrosine phenol. Research groups developing structure-property relationships in peptide chemistry often select this reagent to introduce additional hydrogen-bonding and potential site for further derivatization after peptide assembly. The dihydrochloride monohydrate form supports practical weigh-and-dissolve workflows for coupling steps, enabling consistent incorporation during custom peptide synthesis and library construction when the target sequence requires a tyrosine-like aromatic side chain plus an extra amino handle.
2. Heterocycle And Nitrogen-Rich Intermediates
3-Amino-DL-tyrosine dihydrochloride monohydrate serves as a nitrogen-enriched precursor for medicinal chemistry and pharmaceutical intermediate development, particularly when a tyrosine-derived aromatic motif is needed to build heterocycles. Process and R&D chemists use this material to access downstream scaffolds that retain the phenolic functionality while leveraging the additional amino group for ring formation or late-stage functional elaboration. The salt form is often advantageous in industrial intermediate workflows because it can improve handling and reproducibility during multistep synthesis planning, especially when aqueous or mixed-solvent conditions are used for intermediate preparation and isolation.
3. Analytical Reference For Tyrosine Derivatives
3-Amino-DL-tyrosine dihydrochloride monohydrate is applied as an analytical reference material for method development and characterization of tyrosine-derived compounds in LC-based workflows. Analytical laboratories use this reagent to confirm retention behavior and to support identification strategies for amino acid derivatives that contain both a tyrosine phenolic group and an extra amino substituent. The defined salt composition (dihydrochloride monohydrate) helps standardize sample preparation and calibration practices when comparing derivatized or partially processed mixtures, such as those generated during peptide-chemistry optimization or intermediate synthesis monitoring.
If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at . We will endeavor to provide highly satisfying products and services.
Creative Peptides is a trusted CDMO partner specializing in high-quality peptide synthesis, conjugation, and manufacturing under strict cGMP compliance. With advanced technology platforms and a team of experienced scientists, we deliver tailored peptide solutions to support drug discovery, clinical development, and cosmetic innovation worldwide.
From custom peptide synthesis to complex peptide-drug conjugates, we provide flexible, end-to-end services designed to accelerate timelines and ensure regulatory excellence. Our commitment to quality, reliability, and innovation has made us a preferred partner across the pharmaceutical, biotechnology, and personal care industries.
Read More