Angiotensin III, human, mouse is a heptapeptide, acts as an endogenous angiotensin type 2 receptor (AT2R) agonist, with IC50s of 0.648 nM and 21.1 nM for AT2R and AT1R, respectively.
CAT No: R1204
CAS No:13602-53-4
Synonyms/Alias:ANGIOTENSIN III;Angiotensin III, human, mouse;12687-51-3;Angiotensin III, Human;13602-53-4;5-Ile-angiotensin III;UNII-XH7F04LXTF;Angiotensin III, 5-ile-;1-Desaspartyl-5-isoleucine angiotensin II;XH7F04LXTF;Des-asp(1)-(ile(5))-angiotensin II;(2S)-2-[[(2S)-1-[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoic acid;Angiotensin II, 1-desaspartyl-5-isoleucine-;CHEBI:89666;1-De-L-aspartic acid-5-L-isoleucine-angiotensin II;MFCD00167500;Des-Asp-1-Angiotensin II;SCHEMBL9010604;CHEMBL1702539;BDBM85557;QMMRCKSBBNJCMR-KMZPNFOHSA-N;HY-P1540;AKOS024456669;NCGC00167131-01;CAS_12687-51-3;Angiotensin III trifluoroacetate salt hydrate;CS-0044838;G12439;Angiotensin III (H-L-Arg-L-Val-L-Tyr-L-Ile-L-His-L-Pro-L-Phe-OH);(2S)-2-{[(2S)-1-[(2S)-2-[(2S,3S)-2-[(2S)-2-[(2S)-2-[(2S)-2-amino-5-[(diaminomethylidene)amino]pentanamido]-3-methylbutanamido]-3-(4-hydroxyphenyl)propanamido]-3-methylpentanamido]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidin-2-yl]formamido}-3-phenylpropanoic acid;(S)-2-((S)-1-((6S,9S,12S,15S,18S)-18-((1H-imidazol-4-yl)methyl)-1,6-diamino-15-sec-butyl-12-(4-hydroxybenzyl)-1-imino-9-isopropyl-7,10,13,16-tetraoxo-2,8,11,14,17-pentaazanonadecane)pyrrolidine-2-carboxamido)-3-phenylpropanoic acid;
Angiotensin III, human, mouse is a synthetic peptide corresponding to the endogenous angiotensin III sequence found in both human and murine species. As a bioactive peptide fragment generated from angiotensin II, it plays a pivotal role in the renin-angiotensin system, which regulates key physiological processes such as blood pressure, electrolyte homeostasis, and fluid balance. Its distinct sequence and biological activity make it an essential tool for researchers investigating peptide hormone signaling, receptor specificity, and the broader mechanisms of cardiovascular regulation. The availability of Angiotensin III for research purposes enables detailed exploration of its molecular interactions and functional consequences in a variety of experimental systems.
Receptor binding studies: Angiotensin III is widely utilized in receptor binding assays to characterize the specificity and affinity of angiotensin receptors, particularly AT1 and AT2 subtypes. By serving as a ligand in these assays, the peptide enables precise mapping of receptor-ligand interactions, competitive binding dynamics, and downstream signaling events. Such studies are fundamental for elucidating the pharmacological profiles of angiotensin receptors and for screening novel receptor antagonists or agonists in drug discovery pipelines.
Signal transduction research: As a key effector within the renin-angiotensin cascade, Angiotensin III is instrumental in dissecting intracellular signaling pathways activated by peptide hormones. In vitro and ex vivo models frequently employ this peptide to stimulate cellular responses, facilitating the identification and quantification of second messengers, kinase activation, and gene expression changes. These applications provide mechanistic insight into the modulation of vascular tone, aldosterone secretion, and sodium reabsorption at the cellular level.
Physiological function analysis: The peptide serves as a critical tool in functional studies aimed at understanding the physiological roles of angiotensin fragments beyond angiotensin II. Researchers use Angiotensin III to probe its unique effects on vasoconstriction, renal function, and neuroendocrine regulation. Comparative studies in human and mouse models allow for the delineation of species-specific responses, helping to clarify evolutionary conservation and divergence within the renin-angiotensin system.
Enzymatic processing studies: Angiotensin III is a valuable substrate for investigating the enzymatic pathways that generate and degrade angiotensin peptides. Its use in in vitro enzymatic assays enables the characterization of aminopeptidases and other proteolytic enzymes responsible for peptide maturation and turnover. By tracing the conversion of angiotensin II to III and subsequent metabolites, researchers gain critical information on the regulation of peptide bioavailability and activity within biological systems.
Analytical method development: The defined sequence and stability of Angiotensin III make it an ideal standard for developing and validating analytical techniques such as high-performance liquid chromatography (HPLC), mass spectrometry, and immunoassays. Laboratories rely on this peptide to calibrate detection systems, optimize separation protocols, and ensure the accuracy of quantitative measurements in complex biological samples. These methodological advances underpin robust peptide quantification in both basic research and translational studies.
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