Antazoline Sulfate

Antistine-Privine (Antazoline Sulfate) is a 1st generation antihistamine, with good anticholinergic properties. It is used to relieve nasal congestion and added in eye drops, usually in combination with naphazoline, to relieve the symptoms of allergic conjunctivitis.

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CAT#	10-101-110
CAS	91-75-8 (net), 24359-81-7 (sulfate)
Background	Antazoline is only found in individuals that have used or taken this drug. It is a 1st generation antihistamine that also anticholinergic properties used to relieve nasal congestion and in eye drops, usually in combination with naphazoline, to relieve the symptoms of allergic conjunctivitis. Antazoline binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine.
Synonyms/Alias	2-(N-Phenyl-N-benzyl-aminomethyl)imidazoline · sulfate; 2-[(N-Benzylanilino)methyl]-2-imidazoline · sulfate; 4,5-Dihydro-N-phenyl-N-(phenylmethyl)-1H-imidazole-2-methanamine · sulfate
Chemical Name	N-benzyl-N-(4,5-dihydro-1H-imidazol-2-ylmethyl)aniline;sulfuric acid
M.F/Formula	C17H19N3·H2O4S
M.W/Mr.	363.35
Labeling Target	Histamine Receptor
Application	Conjunctivitis
Appearance	Solid powder
Purity	>98% (or refer to the Certificate of Analysis)
Activity	Antagonist
Areas of Interest	Neurological Disease
Target	Histamine H1 receptor

CAT#	Product Name	M.W	Molecular Formula	Inquiry
10-101-108	Antazoline Hydrochloride Ph. Eur.	265.36 (net), 301.82 (hydrochloride)	C17H20ClN3	Inquiry
10-101-109	Antazoline Phosphate	265.36 (net), 363.35 (phosphate)	C17H22N3O4P	Inquiry

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Source#	Synthetic
Solubility	Soluble in DMSO
Shipping Condition	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Short-term Storage Conditions	Dry, dark and at 0 - 4 °C
Long-term Storage Conditions	-20 °C
InChI	InChI=1S/C17H19N3/c1-3-7-15(8-4-1)13-20(14-17-18-11-12-19-17)16-9-5-2-6-10-16/h1-10H,11-14H2,(H,18,19)
InChI Key	REYFJDPCWQRWAA-UHFFFAOYSA-N
Canonical SMILES	C1CN=C(N1)CN(CC2=CC=CC=C2)C3=CC=CC=C3.OS(=O)(=O)O
BoilingPoint	475.5±38.0 °C at 760 mmHg
ShelfLife	>2 years if stored properly
References	Antazoline seems to be safe agent in termination of AF in patients undergoing pulmonary vein isolation. We also observed satisfying efficacy, which needs to be proved in a randomized clinical trial. Balsam P, Koźluk E, Peller M, et al. Antazoline for termination of atrial fibrillation during the procedure of pulmonary veins isolation[J]. Advances in medical sciences, 2015, 60(2): 231-235. Intravenous antazoline was effective and safe in the rapid conversion of non-valvular paroxysmal atrial fibrillation to sinus rhythm in patients without heart failure. Maciag A, Farkowski M M, Chwyczko T, et al. Efficacy and safety of antazoline in the rapid cardioversion of paroxysmal atrial fibrillation (the AnPAF Study)[J]. EP Europace, 2016: euw384. Antazoline is an old antihistaminic and new antiarrhythmic agent with unknown mechanisms of action which recently has been shown to effectively terminate atrial fibrillation. The aim of study was to examine the effects of antazoline on hemodynamic and ECG parameters. Piotrowski R, Giebułtowicz J, Baran J, et al. Antazoline—insights into drug‐induced electrocardiographic and hemodynamic effects: Results of the ELEPHANT II substudy[J]. Annals of Noninvasive Electrocardiology, 2017.
Melting Point	159ºC