ATWLPPR Peptide assembles aromatic, hydrophobic, and basic residues that influence local folding and ligand recognition. The sequence supports exploration of β-turn formation and receptor-binding determinants. Researchers evaluate its interactions in aqueous and membrane-mimetic systems. Use spans peptide-based probe design, structural modeling, and bioorganic interaction studies.
CAT No: R2298
CAS No:272121-15-0
Synonyms/Alias:ATWLPPR Peptide;CHEMBL1095672;272121-15-0;Ala-Thr-Trp-Leu-Pro-Pro-Arg;ATWLPPR;HY-P1663;BDBM50317441;CS-0084563;(2S)-2-[[(2S)-1-[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-aminopropanoyl]amino]-3-hydroxybutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-methylpentanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid;
ATWLPPR Peptide, also known as the VEGF165 receptor-binding heptapeptide, is a synthetic carbohydrate compound widely recognized for its ability to interact specifically with the vascular endothelial growth factor receptor-2 (VEGFR-2). Characterized by the amino acid sequence Ala-Thr-Trp-Leu-Pro-Pro-Arg, this peptide exhibits a high degree of specificity and affinity for its target, making it a valuable tool in a variety of research applications. Its unique structure enables selective modulation of VEGF-mediated signaling pathways, which are fundamental to processes such as angiogenesis, vascular permeability, and cellular migration. As a research reagent, ATWLPPR Peptide is appreciated for its stability, ease of synthesis, and compatibility with both in vitro and in vivo experimental systems, thereby supporting a broad spectrum of investigative studies in molecular biology, biochemistry, and biomedical sciences.
Angiogenesis Research: In the field of angiogenesis research, ATWLPPR serves as an essential inhibitor of VEGFR-2 signaling. Researchers utilize this peptide to dissect the molecular mechanisms underlying new blood vessel formation by selectively blocking the interaction between VEGF165 and its primary receptor. By doing so, it provides a controlled experimental approach to study the downstream effects of VEGFR-2 inhibition, such as changes in endothelial cell proliferation, migration, and tube formation. This targeted modulation is crucial for unraveling the complexities of vascular development and identifying potential molecular targets for therapeutic intervention in pathological angiogenesis.
Cancer Biology Studies: The heptapeptide is a powerful tool in cancer biology, where abnormal angiogenesis supports tumor growth and metastasis. Scientists employ ATWLPPR to investigate how VEGFR-2 blockade influences tumor vascularization, microenvironment dynamics, and cancer cell behavior. By incorporating this peptide into experimental models, researchers can assess the impact of specific VEGF pathway inhibition on tumor progression, offering insights into potential anti-angiogenic strategies for cancer research. Its selective action allows for precise elucidation of the role of VEGFR-2 in tumor angiogenesis without off-target effects on other signaling pathways.
Ophthalmological Research: In ophthalmology, VEGF signaling plays a pivotal role in diseases characterized by abnormal blood vessel growth in the eye, such as diabetic retinopathy and age-related macular degeneration. The ATWLPPR peptide is utilized in laboratory models to study the mechanisms by which VEGFR-2 contributes to pathological neovascularization in ocular tissues. Through its specific inhibition of VEGFR-2, the peptide enables researchers to explore new avenues for modulating retinal angiogenesis and to evaluate the effects of VEGF pathway blockade on retinal cell health and function, thereby advancing the understanding of ocular vascular disorders.
Vascular Permeability and Inflammation Studies: The peptide is also instrumental in investigating the regulation of vascular permeability and inflammation. VEGF-induced changes in vascular integrity are central to a variety of physiological and pathological processes, including tissue edema and inflammatory responses. By selectively inhibiting VEGFR-2 with ATWLPPR, researchers can delineate the contribution of this receptor to endothelial barrier function and leukocyte transmigration. Such studies provide valuable data on the interplay between VEGF signaling, vascular leakage, and inflammatory cell recruitment, which are relevant to conditions ranging from acute inflammation to chronic vascular diseases.
Neuroscience and Blood-Brain Barrier Research: In neuroscience, the integrity of the blood-brain barrier (BBB) is a critical factor in maintaining central nervous system homeostasis. The ATWLPPR peptide is employed to explore how VEGFR-2-mediated signaling affects BBB permeability and neurovascular interactions. By modulating VEGF pathways, investigators can examine the molecular events that compromise or restore BBB function under various experimental conditions, such as hypoxia, neuroinflammation, or injury. These studies are essential for understanding the molecular basis of BBB regulation and for identifying new research targets in neurological disease models, further highlighting the versatile utility of ATWLPPR across diverse scientific disciplines.
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