Aviptadil Acetate is a vasoactive intestinal peptide for lung and immune research. Purchase this synthetic peptide for studies on pulmonary health and inflammation.
CAT No: 10-101-43
CAS No:40077-57-4
Synonyms/Alias:VIP; Vasoactive Intestinal Polypeptide; invicorp; Aviptadil
Chemical Name:4-[[1-[[1-[[1-[[1-[[1-[[1-[[1-[[1-[[1-[[1-[[1-[[6-amino-1-[[5-amino-1-[[1-[[1-[[1-[[6-amino-1-[[6-amino-1-[[1-[[1-[[4-amino-1-[[1-[[1-[[1-[(1,4-diamino-1,4-dioxobutan-2-yl)amino]-4-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]amino]-1-oxohexan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-[[2-[[2-amino-3-(1H-imidazol-4-yl)propanoyl]amino]-3-hydroxypropanoyl]amino]-4-oxobutanoic acid
Aviptadil Acetate, a synthetic peptide corresponding to the human vasoactive intestinal peptide (VIP), is recognized for its unique structural and functional properties that make it highly valuable in scientific research and experimental applications. Characterized by its ability to interact with specific receptors and modulate various physiological pathways, Aviptadil Acetate is widely employed in laboratory studies exploring neuroendocrine, immunological, and pulmonary systems. Its peptide-based nature ensures high specificity in binding interactions, enabling researchers to investigate complex cellular mechanisms with precision and reliability. Additionally, its stability and solubility in aqueous solutions facilitate its integration into diverse experimental protocols, supporting both in vitro and in vivo studies across multiple scientific disciplines.
Neuroscience Research: In neuroscience, Aviptadil Acetate serves as a powerful tool for investigating neuroprotective mechanisms and neurotransmitter modulation. Researchers utilize it to study the role of VIP in regulating neuronal excitability, synaptic plasticity, and neuroinflammation. By applying this peptide in neuronal cell cultures or animal models, scientists can delineate its influence on neurodegenerative processes, neural repair, and the maintenance of cognitive functions. These studies contribute to a deeper understanding of central nervous system homeostasis and the potential for targeting VIP pathways in neurological disorders.
Pulmonary Biology: Aviptadil is extensively used in pulmonary research to elucidate its effects on bronchial smooth muscle relaxation, vascular permeability, and respiratory epithelial integrity. Experimental models incorporating this peptide help characterize its capacity to modulate inflammatory responses and support alveolar function under stress conditions. By leveraging its vasoactive and immunomodulatory properties, researchers gain insights into the peptide's potential to mitigate pulmonary inflammation, enhance barrier function, and maintain optimal gas exchange in the lungs.
Immunology Studies: Within the field of immunology, Aviptadil Acetate is employed to analyze immune cell signaling and cytokine regulation. Its interaction with immune cell receptors enables the dissection of pathways involved in T-cell activation, macrophage function, and cytokine secretion profiles. Experimental protocols using this peptide facilitate the investigation of immune tolerance, autoimmunity, and the modulation of inflammatory cascades, providing a foundation for developing novel immunoregulatory strategies in preclinical models.
Gastrointestinal Physiology: In studies focused on gastrointestinal function, Aviptadil Acetate is applied to examine its influence on smooth muscle tone, secretion of digestive fluids, and mucosal protection. Researchers exploit its ability to stimulate intestinal motility and regulate electrolyte balance, making it a valuable agent in experiments assessing gut barrier integrity and the interplay between the enteric nervous system and gastrointestinal immune responses. This research supports broader efforts to unravel the complex regulatory networks governing digestive health.
Endocrine and Metabolic Research: The peptide is also utilized in endocrine and metabolic studies, where its role in modulating hormone release and energy homeostasis is explored. Investigators employ Aviptadil Acetate to probe the mechanisms underlying pancreatic islet function, insulin secretion, and glucose metabolism. Its effects on adipose tissue signaling and lipid metabolism are also of interest, enabling comprehensive analyses of metabolic regulation and the identification of novel targets for metabolic modulation in experimental systems.
Collectively, Aviptadil Acetate stands as a versatile and indispensable reagent in advanced scientific research, supporting multifaceted investigations across neuroscience, pulmonary biology, immunology, gastrointestinal physiology, and metabolic studies. Its precise receptor interactions, coupled with robust bioactivity, empower researchers to dissect intricate biological processes and drive innovation in experimental design. By integrating this peptide into their research workflows, scientists can expand the frontiers of knowledge in fundamental and translational science, paving the way for new discoveries and a deeper understanding of physiological regulation.
Vasoactive Intestinal Peptide (VIP) is a neuropeptide, expressed by lymphoid as well as neural cells, which has diverse effects on the cellular mediators of inflammation and immunity and is also a potent neurotransmitter. VIP seems to have a major role in the homeostasis of the respiratory system, while several studies, including clinical trials, suggest that VIP-inhaled agonists could be used in respiratory therapeutics.
Mathioudakis A G, Chatzimavridou-Grigoriadou V, Evangelopoulou E, et al. Vasoactive intestinal peptide inhaled agonists: potential role in respiratory therapeutics[J]. Hippokratia, 2013, 17(1): 12.
Pulmonary hypertension (PH) leads to an increased right ventricular workload, cardiac failure and death. In idiopathic pulmonary arterial hypertension (PAH) the vasodilating vasoactive intestinal peptide (aviptadil) is deficient. The aim of the present study was to test the acute effects on haemodynamics and blood gases, and the safety, of a single dose of inhaled aviptadil in chronic PH. A total of 20 patients with PH (PAH in nine, PH in lung disease in eight and chronic thromboembolic PH in three) inhaled a single 100-microg dose of aviptadil during right-heart catheterisation. Haemodynamics and blood gases were measured. Aviptadil aerosol caused a small and temporary but significant selective pulmonary vasodilation, an improved stroke volume and mixed venous oxygen saturation. Overall, six patients experienced a pulmonary vascular resistance reduction of >20%. In patients with significant lung disease, aviptadil tended to improve oxygenation. The pulmonary vasodilating effect of aviptadil aerosol was modest and short-lived, did not cause any side-effects and led to a reduced workload of the right ventricle without affecting systemic blood pressure. Aviptadil inhalation tended to improve oxygenation in patients with significant lung disease. Further studies are needed to evaluate the full therapeutic potential of aviptadil aerosol, including higher doses and chronic treatment.
Leuchte H H, Baezner C, Baumgartner R A, et al. Inhalation of vasoactive intestinal peptide in pulmonary hypertension[J]. European Respiratory Journal, 2008, 32(5): 1289-1294.
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