Aviptadil Acetate is a vasoactive intestinal peptide for lung and immune research. Purchase this synthetic peptide for studies on pulmonary health and inflammation.
CAT No: 10-101-43
CAS No:40077-57-4
Synonyms/Alias:VIP; Vasoactive Intestinal Polypeptide; invicorp; Aviptadil
Chemical Name:4-[[1-[[1-[[1-[[1-[[1-[[1-[[1-[[1-[[1-[[1-[[1-[[6-amino-1-[[5-amino-1-[[1-[[1-[[1-[[6-amino-1-[[6-amino-1-[[1-[[1-[[4-amino-1-[[1-[[1-[[1-[(1,4-diamino-1,4-dioxobutan-2-yl)amino]-4-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]amino]-1-oxohexan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-[[2-[[2-amino-3-(1H-imidazol-4-yl)propanoyl]amino]-3-hydroxypropanoyl]amino]-4-oxobutanoic acid
Aviptadil Acetate is a synthetic peptide corresponding to the human vasoactive intestinal peptide (VIP), a 28-amino acid neuropeptide with potent vasodilatory, immunomodulatory, and bronchodilatory properties. As a member of the secretin/glucagon peptide family, Aviptadil Acetate is widely recognized for its ability to interact with specific VIP receptors, mediating diverse physiological responses in the nervous, immune, and respiratory systems. Its unique biochemical profile, characterized by high receptor affinity and stability, makes it a valuable tool for researchers investigating peptide signaling, receptor pharmacology, and the molecular mechanisms underlying neuroimmune communication.
Receptor Pharmacology: Aviptadil Acetate serves as a critical reagent for the study of VIP receptor subtypes, including VPAC1 and VPAC2, in cellular and tissue-based assays. By selectively binding to these G protein-coupled receptors, the peptide enables detailed characterization of downstream signaling pathways, such as cyclic AMP production and protein kinase activation. Researchers utilize Aviptadil Acetate to dissect receptor specificity, ligand-receptor interactions, and the functional consequences of receptor modulation, thereby advancing understanding of peptide-mediated signal transduction.
Neurobiology Research: The peptide is extensively employed in neurobiological investigations focused on neurotransmission, neuroprotection, and neuroinflammation. Owing to its well-defined role in modulating synaptic activity and neuronal excitability, Aviptadil Acetate facilitates studies on neural plasticity, neuropeptide release, and the regulation of central and peripheral nervous system functions. Experimental models benefit from its application in elucidating the contribution of VIP signaling to neuronal survival, glial cell interactions, and the maintenance of neural homeostasis.
Immunological Studies: Aviptadil Acetate is instrumental in immunological research, particularly in exploring the anti-inflammatory and immunoregulatory effects of VIP. Through its action on immune cells such as T lymphocytes, macrophages, and dendritic cells, the peptide enables detailed analysis of cytokine secretion, cell migration, and immune tolerance mechanisms. Its use supports investigations into the modulation of inflammatory responses, the suppression of pro-inflammatory mediators, and the maintenance of immune equilibrium in vitro and ex vivo systems.
Respiratory Physiology: The bronchodilatory and vasodilatory properties of Aviptadil Acetate are leveraged in studies of airway smooth muscle relaxation, pulmonary vascular tone, and respiratory epithelial function. Researchers apply the peptide in organ bath experiments, cell culture models, and ex vivo lung preparations to investigate the molecular basis of airway regulation, the effects of neuropeptides on bronchomotor tone, and the interplay between neural and vascular components in the respiratory tract. Such applications provide insight into the fundamental mechanisms governing airway responsiveness and pulmonary homeostasis.
Peptide Drug Development: The well-characterized structure and bioactivity of Aviptadil Acetate make it a valuable reference compound in the design, synthesis, and optimization of novel peptide-based therapeutics. Medicinal chemistry and pharmaceutical research teams utilize the peptide as a benchmark for evaluating structure-activity relationships, receptor selectivity, and metabolic stability. Its use in preclinical assay development and high-throughput screening contributes to the identification of new peptide analogs with improved pharmacological profiles for research purposes.
Vasoactive Intestinal Peptide (VIP) is a neuropeptide, expressed by lymphoid as well as neural cells, which has diverse effects on the cellular mediators of inflammation and immunity and is also a potent neurotransmitter. VIP seems to have a major role in the homeostasis of the respiratory system, while several studies, including clinical trials, suggest that VIP-inhaled agonists could be used in respiratory therapeutics.
Mathioudakis A G, Chatzimavridou-Grigoriadou V, Evangelopoulou E, et al. Vasoactive intestinal peptide inhaled agonists: potential role in respiratory therapeutics[J]. Hippokratia, 2013, 17(1): 12.
Pulmonary hypertension (PH) leads to an increased right ventricular workload, cardiac failure and death. In idiopathic pulmonary arterial hypertension (PAH) the vasodilating vasoactive intestinal peptide (aviptadil) is deficient. The aim of the present study was to test the acute effects on haemodynamics and blood gases, and the safety, of a single dose of inhaled aviptadil in chronic PH. A total of 20 patients with PH (PAH in nine, PH in lung disease in eight and chronic thromboembolic PH in three) inhaled a single 100-microg dose of aviptadil during right-heart catheterisation. Haemodynamics and blood gases were measured. Aviptadil aerosol caused a small and temporary but significant selective pulmonary vasodilation, an improved stroke volume and mixed venous oxygen saturation. Overall, six patients experienced a pulmonary vascular resistance reduction of >20%. In patients with significant lung disease, aviptadil tended to improve oxygenation. The pulmonary vasodilating effect of aviptadil aerosol was modest and short-lived, did not cause any side-effects and led to a reduced workload of the right ventricle without affecting systemic blood pressure. Aviptadil inhalation tended to improve oxygenation in patients with significant lung disease. Further studies are needed to evaluate the full therapeutic potential of aviptadil aerosol, including higher doses and chronic treatment.
Leuchte H H, Baezner C, Baumgartner R A, et al. Inhalation of vasoactive intestinal peptide in pulmonary hypertension[J]. European Respiratory Journal, 2008, 32(5): 1289-1294.
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