AZP-531 is an analogue of unacylated ghrelin designed to improve glycaemic control and reduce weight.
CAT No: R1230
CAS No:1088543-62-7
Synonyms/Alias:1088543-62-7;Cyclo(L-arginyl-L-valyl-L-glutaminyl-L-seryl-L-prolyl-L-a-glutamyl-L-histidyl-L-glutaminyl);3-[6,15-bis(3-amino-3-oxopropyl)-12-[3-(diaminomethylideneamino)propyl]-3-(hydroxymethyl)-18-(1H-imidazol-5-ylmethyl)-2,5,8,11,14,17,20,23-octaoxo-9-propan-2-yl-1,4,7,10,13,16,19,22-octazabicyclo[22.3.0]heptacosan-21-yl]propanoic acid;Livoletide?;NTB54362;DA-71253;G16132;
AZP-531 is a synthetic peptide analog derived from unacylated ghrelin, designed to mimic and enhance the biological activities of its parent hormone while offering improved stability and selectivity. Structurally, it is engineered to retain the beneficial metabolic and signaling properties of unacylated ghrelin, without the orexigenic effects associated with its acylated counterpart. AZP-531 has attracted significant interest in the biochemical research community due to its unique profile and its ability to modulate various physiological pathways, particularly those related to metabolism, energy homeostasis, and cellular signaling. Its distinct mechanism of action and peptide-based structure make it a valuable tool for probing complex biological systems and advancing peptide research.
Metabolic Research: AZP-531 is widely utilized in studies investigating glucose metabolism and insulin sensitivity. As an unacylated ghrelin analog, it provides researchers with a means to dissect the specific contributions of ghrelin signaling pathways to metabolic regulation, independent of the appetite-stimulating effects of the acylated form. Experimental models have employed this peptide to elucidate the molecular interplay between ghrelin receptors, pancreatic beta-cell function, and peripheral glucose uptake, offering insights into the modulation of metabolic homeostasis.
Peptide Receptor Pharmacology: The compound serves as a critical tool in characterizing the pharmacology of ghrelin receptor subtypes and their downstream signaling cascades. By selectively engaging unacylated ghrelin-responsive pathways, AZP-531 enables detailed analysis of receptor-ligand interactions, G protein coupling, and secondary messenger activation. Such studies are essential for advancing understanding of peptide hormone signaling and for identifying novel targets within the ghrelin axis for further research and development.
Obesity and Adiposity Studies: In the context of obesity research, AZP-531 is used to explore the influence of unacylated ghrelin analogs on adipocyte biology, lipid metabolism, and energy expenditure. Its ability to modulate fat storage and mobilization without promoting food intake distinguishes it from other peptide hormones, allowing for focused investigation into the mechanisms governing adipose tissue function and systemic energy balance. This makes it a preferred reagent for dissecting the non-orexigenic roles of ghrelin derivatives in metabolic disorders.
Cell Signaling Investigations: Beyond metabolic pathways, AZP-531 is employed in studies examining broader aspects of cell signaling and hormone cross-talk. Researchers leverage its stability and selectivity to probe intracellular signaling networks, such as those involving MAPK, PI3K/Akt, and AMPK pathways, which are implicated in cellular growth, differentiation, and stress responses. These investigations contribute to a deeper understanding of how peptide hormones orchestrate complex cellular events and interact with other regulatory systems.
Peptide Therapeutic Development: The unique properties of AZP-531 make it an attractive candidate for preclinical evaluation in the development of next-generation peptide-based modulators. Its structural modifications and favorable pharmacodynamic profile provide a template for designing novel analogs with tailored biological activities. In this context, the peptide is used as a reference compound in structure-activity relationship studies, stability assessments, and in vitro functional assays, supporting innovation in peptide drug discovery and optimization for research applications.
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