Bestatin hydrochloride is a reversible inhibitor of aminopeptidase enzymes, namely Aminopeptidase B, Aminopeptidase M (CD13), and leucine aminopeptidase (LAP3). Inhibition of these proteins by bestatin correlates to apoptosis induction in oncogenic cells. Bestatin is also a potent inhibitor of leukotriene A4 hydrolase (LTA4). It is potentially used for cancer treatment.
Registration of APIs CMC information required for an IND
IND and NDA support Drug master files (DMF) filing
Synonyms/Alias | Aminopeptidase inhibitor; leucine aminopeptidase; aminopeptidase B; NK-421 |
M.F/Formula | C16H24N2O4 · HCl |
M.W/Mr. | 344.83 |
Labeling Target | Aminopeptidase |
Appearance | White solid powder |
Purity | >98% (or refer to the Certificate of Analysis) |
Activity | Inhibitor |
Long-term Storage Conditions | Soluble in DMSO |
Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
Short-term Storage Conditions | Dry, dark and at 0 - 4 °C |
Solubility | -20 °C |
InChI | InChI=1S/C16H24N2O4.ClH/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11;/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22);1H/t12-,13+,14+;/m1./s1 |
InChI Key | XGDFITZJGKUSDK-UDYGKFQRSA-N |
Isomeric SMILES | CC(C)C[C@@H](C(=O)O)NC(=O)[C@H]([C@@H](CC1=CC=CC=C1)N)O.Cl |
BoilingPoint | 604.7ºC at 760 mmHg |
ShelfLife | >2 years if stored properly |
Melting Point | 216-218 °C |
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