Buserelin contains a modified peptide backbone that stabilizes secondary-structure elements and enhances interaction studies. Its residue composition supports conformational flexibility and solvent-dependent transitions. Researchers evaluate its binding determinants and hydrogen-bond networks. Applications include peptide engineering, biophysical analysis, and structural modeling.
CAT No: R2693
CAS No:57982-77-1
Synonyms/Alias:BUSERELIN;57982-77-1;Etilamide;Buserelina;Busereline;Buserelinum;Metrelef;Tiloryth;PXW8U3YXDV;UNII-PXW8U3YXDV;(Des-Gly10,D-Ser(tBu)6,Pro-NHEt9)-LHRH;ICI 123215;CCRIS 2657;HOE 766A;Busereline [INN-French];Buserelinum [INN-Latin];EINECS 261-061-9;Buserelina [INN-Spanish];HOE 766;(D-Ser(tbu)(sup 6)-EA(sup 10))-LHRH;Buserelin (INN);S 746766;BUSERELIN [INN];(D-Ser(Bu(sup t)(sup 6)))-LH-RH(1-9)nonapeptide-ethylamide;Busereline (INN-French);Buserelinum (INN-Latin);Buserelina (INN-Spanish);BUSERELIN (MART.);BUSERELIN [MART.];BUSERELIN (EP MONOGRAPH);BUSERELIN [EP MONOGRAPH];NSC725176;Buserelin [INN:BAN];Tiloryth (TN);BSRL;Buserelin acetate salt;D-Ser-(TBu)(sup 6)-LHRH-ethylamide;BUSERELIN [MI];BUSERELIN [WHO-DD];SCHEMBL13354;GTPL3860;Buserelin for NMR identification;CHEMBL2110824;D-Ser(tbu(sup 6))-LH-RH-(1-9)-nonapeptide ethylamide;SCHEMBL19409318;SCHEMBL19459955;Buserelin for peak identification;L02AE01;CHEBI:135907;CUWODFFVMXJOKD-UVLQAERKSA-N;DTXSID301024155;MFCD00941414;AKOS015994645;AKOS030213242;HS-2005;NCGC00181295-01;FD109219;D07259;Q414745;S74-6766;(Des-Gly10,D-Ser(tBu)6,Pro-NHEt 9)-LHRH acetate salt;des-Gly10-[D-Ser[t-Bu]6]-LH-RH ethylamide acetate salt;pGlu-His-Trp-Ser-Tyr-D-Ser(t-Bu)-Leu-Arg-Pro-NHEt acetate salt;Pyr-His-Trp-Ser-Tyr-D-Ser(tBu)-Leu-Arg-Pro-NHEt; pE-HWSY(dS)(tBu)LRP-NHEt;261-061-9;5-oxo-l-prolyl-l-histidyl-l-tryptophyl-l-seryl-l-tyrosyl-o-tert-butyl-d-seryl-l-leucyl-l-arginyl-n-ethyl-l-prolinamide;6-(O-(1,1-Dimethylethyl)-D-serine)-9-(N-ethyl-L-prolinamide)-10-deglycinamide Luteinizing Hormone-Releasing Factor (Pig);6-(O-(1,1-Dimethylethyl)-D-serine)-9-(N-ethyl-L-prolinamide)-10-deglycinamide-luteinizing Hormone-releasing Factor (Pig);
Buserelin is a synthetic peptide analog of gonadotropin-releasing hormone (GnRH), designed to mimic the structure and function of the endogenous decapeptide hormone responsible for regulating the synthesis and release of gonadotropins from the anterior pituitary. As a potent GnRH agonist, buserelin exhibits high receptor affinity and prolonged biological activity, making it a valuable tool for dissecting hormone signaling pathways, neuroendocrine regulation, and reproductive physiology in a variety of experimental systems. Its robust biochemical properties and well-characterized mechanism of action have established buserelin as a critical reagent in both fundamental and applied research settings focused on peptide hormone function and endocrine modulation.
Endocrine signaling research: Buserelin serves as a precise molecular probe for investigating the mechanisms underlying hypothalamic-pituitary-gonadal (HPG) axis regulation. By stimulating GnRH receptors with high specificity, it enables detailed studies of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion dynamics, receptor desensitization, and downstream intracellular signaling cascades. Researchers utilize this peptide to elucidate the temporal patterns of hormone release and feedback regulation, contributing to a deeper understanding of neuroendocrine integration in vertebrate species.
Reproductive biology studies: The compound is widely employed in experimental models to manipulate reproductive hormone levels and synchronize gonadotropin surges. Its application facilitates the study of ovulation, spermatogenesis, and gonadal steroidogenesis by providing controlled activation of the reproductive axis. Buserelin's ability to induce or suppress endogenous gonadotropin release makes it an indispensable tool for exploring the physiological and molecular mechanisms governing fertility and reproductive cycles in both in vivo and in vitro systems.
Peptide receptor characterization: As a well-defined GnRH analog, buserelin is instrumental in characterizing the binding properties, ligand specificity, and signal transduction mechanisms of GnRH receptors. Functional assays employing this agonist allow for the assessment of receptor affinity, density, and responsiveness in various cell types and tissue preparations. Such studies are essential for mapping receptor distribution, understanding receptor-ligand interactions, and developing new strategies for modulating peptide hormone signaling.
Pharmacological assay development: Buserelin is frequently incorporated into in vitro and ex vivo assay platforms to evaluate the activity of GnRH receptor agonists and antagonists, screen for novel modulators, and validate bioanalytical methodologies. Its consistent potency and well-documented pharmacodynamics enable reliable benchmarking and standardization of assay systems, supporting high-throughput screening efforts and mechanistic pharmacology research in academic and industrial laboratories.
Peptide synthesis and analytical validation: The compound also serves as a reference standard and model peptide in the development and optimization of peptide synthesis protocols and analytical methods. Its defined sequence and biological activity make it suitable for testing chromatographic separation, mass spectrometric detection, and peptide quantitation techniques. These applications contribute to advancements in peptide chemistry, quality control, and the broader field of synthetic peptide research.
Through these diverse research applications, buserelin provides a powerful platform for advancing knowledge in neuroendocrinology, reproductive biology, peptide receptor pharmacology, and analytical biochemistry. Its versatile utility and well-characterized properties ensure continued relevance across a wide range of scientific disciplines focused on hormone signaling and peptide-based investigation.
1. Autoinhibition and phosphorylation-induced activation of phospholipase C-γ isozymes
5. SERS spectrum of the peptide thymosin‐β4 obtained with Ag nanorod substrate
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