Buserelin contains a modified peptide backbone that stabilizes secondary-structure elements and enhances interaction studies. Its residue composition supports conformational flexibility and solvent-dependent transitions. Researchers evaluate its binding determinants and hydrogen-bond networks. Applications include peptide engineering, biophysical analysis, and structural modeling.
CAT No: R2693
CAS No:57982-77-1
Synonyms/Alias:BUSERELIN;57982-77-1;Etilamide;Buserelina;Busereline;Buserelinum;Metrelef;Tiloryth;PXW8U3YXDV;UNII-PXW8U3YXDV;(Des-Gly10,D-Ser(tBu)6,Pro-NHEt9)-LHRH;ICI 123215;CCRIS 2657;HOE 766A;Busereline [INN-French];Buserelinum [INN-Latin];EINECS 261-061-9;Buserelina [INN-Spanish];HOE 766;(D-Ser(tbu)(sup 6)-EA(sup 10))-LHRH;Buserelin (INN);S 746766;BUSERELIN [INN];(D-Ser(Bu(sup t)(sup 6)))-LH-RH(1-9)nonapeptide-ethylamide;Busereline (INN-French);Buserelinum (INN-Latin);Buserelina (INN-Spanish);BUSERELIN (MART.);BUSERELIN [MART.];BUSERELIN (EP MONOGRAPH);BUSERELIN [EP MONOGRAPH];NSC725176;Buserelin [INN:BAN];Tiloryth (TN);BSRL;Buserelin acetate salt;D-Ser-(TBu)(sup 6)-LHRH-ethylamide;BUSERELIN [MI];BUSERELIN [WHO-DD];SCHEMBL13354;GTPL3860;Buserelin for NMR identification;CHEMBL2110824;D-Ser(tbu(sup 6))-LH-RH-(1-9)-nonapeptide ethylamide;SCHEMBL19409318;SCHEMBL19459955;Buserelin for peak identification;L02AE01;CHEBI:135907;CUWODFFVMXJOKD-UVLQAERKSA-N;DTXSID301024155;MFCD00941414;AKOS015994645;AKOS030213242;HS-2005;NCGC00181295-01;FD109219;D07259;Q414745;S74-6766;(Des-Gly10,D-Ser(tBu)6,Pro-NHEt 9)-LHRH acetate salt;des-Gly10-[D-Ser[t-Bu]6]-LH-RH ethylamide acetate salt;pGlu-His-Trp-Ser-Tyr-D-Ser(t-Bu)-Leu-Arg-Pro-NHEt acetate salt;Pyr-His-Trp-Ser-Tyr-D-Ser(tBu)-Leu-Arg-Pro-NHEt; pE-HWSY(dS)(tBu)LRP-NHEt;261-061-9;5-oxo-l-prolyl-l-histidyl-l-tryptophyl-l-seryl-l-tyrosyl-o-tert-butyl-d-seryl-l-leucyl-l-arginyl-n-ethyl-l-prolinamide;6-(O-(1,1-Dimethylethyl)-D-serine)-9-(N-ethyl-L-prolinamide)-10-deglycinamide Luteinizing Hormone-Releasing Factor (Pig);6-(O-(1,1-Dimethylethyl)-D-serine)-9-(N-ethyl-L-prolinamide)-10-deglycinamide-luteinizing Hormone-releasing Factor (Pig);
Buserelin, a synthetic analog of gonadotropin-releasing hormone (GnRH), is a potent peptide compound widely recognized for its ability to modulate the hypothalamic-pituitary-gonadal axis. Structurally engineered to enhance stability and bioactivity compared to natural GnRH, Buserelin exhibits a high affinity for GnRH receptors, resulting in pronounced effects on the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Its unique molecular configuration enables resistance to enzymatic degradation, making it an invaluable tool in various research and experimental settings. Buserelin's robust performance in stimulating or suppressing gonadotropin release underlies its broad utility across multiple scientific domains, including endocrinology, reproductive biology, and animal breeding research. As a peptide with well-characterized pharmacological properties, Buserelin supports advanced study designs where precise hormonal regulation is essential.
Reproductive Physiology Research: In the field of reproductive physiology, Buserelin serves as a critical agent for elucidating the mechanisms governing gonadotropin release and feedback regulation within the hypothalamic-pituitary-gonadal axis. Researchers utilize this GnRH analog to induce controlled surges of LH and FSH in experimental models, facilitating the investigation of ovarian follicular development, ovulation timing, and corpus luteum function. By enabling precise manipulation of hormonal cycles, Buserelin allows scientists to dissect the temporal dynamics of reproductive events and to explore the effects of exogenous hormonal intervention on fertility parameters in both in vitro and in vivo systems.
Endocrine System Modeling: Buserelin is extensively applied in the modeling of endocrine system disorders, particularly those involving dysregulation of gonadotropin secretion. Its predictable action on pituitary hormone release makes it an ideal compound for simulating conditions such as hypogonadotropic hypogonadism or hypergonadotropic states in animal models. By administering Buserelin in controlled regimens, investigators can mimic pathological hormonal environments, thereby advancing the understanding of disease mechanisms and the evaluation of potential therapeutic interventions at the preclinical stage.
Animal Breeding and Reproductive Management: Within agricultural and veterinary research, Buserelin plays a significant role in optimizing breeding programs and reproductive management protocols. Its ability to synchronize estrus and induce ovulation in livestock species such as cattle, swine, and equines has led to its integration into artificial insemination and embryo transfer protocols. By precisely timing ovulation, Buserelin enhances the predictability and efficiency of breeding schedules, contributing to improved reproductive outcomes and genetic advancement in animal populations.
Cellular Signaling and Receptor Studies: The use of Buserelin extends to cellular and molecular research focused on GnRH receptor biology and downstream signaling pathways. As a selective agonist, this peptide enables the activation of GnRH receptors in cultured pituitary cells or transfected cell lines, providing a platform for dissecting receptor-ligand interactions, signal transduction mechanisms, and gene expression responses. Such studies are pivotal for unraveling the complexities of GnRH-mediated cellular communication and for identifying novel targets involved in reproductive endocrinology.
Comparative Endocrinology Investigations: Buserelin's application is not limited to traditional laboratory species; it is also employed in comparative endocrinology to assess the conservation and divergence of GnRH signaling across vertebrate taxa. By administering it to a variety of animal models, researchers can compare the physiological and molecular responses to GnRH analog stimulation, thereby gaining insights into the evolutionary adaptations of reproductive endocrine systems. These comparative studies contribute to a broader understanding of reproductive strategies and hormonal regulation in diverse biological contexts.
Peptide-based Hormonal Research: The versatility of Buserelin as a research tool underscores its value in peptide-based hormonal investigations. Whether employed to probe feedback mechanisms, assess receptor pharmacodynamics, or refine experimental models of reproductive function, this GnRH analog offers precise, reproducible control over gonadotropin dynamics. Its application continues to drive advancements in basic and applied endocrinology, supporting the development of innovative research methodologies and enhancing our comprehension of hormonal regulation in health and disease.
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