Cagrilintide is a promising peptide drug used in the biomedical field. Its mechanism of action involves mimicking the function of amylin, a hormone responsible for glucose control.
CAT No: R2067
CAS No:1415456-99-3
Synonyms/Alias:Cagrilintide;1415456-99-3;Cagrilintide [INN];AO43BIF1U8;LDERDVMBIYGIOI-IZVMHKDJSA-N;EX-A10092;AT42613;
Chemical Name:20-[[(1S)-4-[[(2S)-6-amino-1-[[(4R,7S,10S,13S,16S,19R)-4-[[(2S)-1-[[(2S,3R)-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-4-amino-1-[[(2R)-4-amino-1-[[(2S)-1-[[2-[(2S)-2-[[(2S,3S)-1-[[(2S)-1-[(2S)-2-[(2S)-2-[[(2S,3R)-1-[[(2S)-4-amino-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-4-amino-1-[[(2S,3R)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-3-hydroxy-1-oxobutan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]carbamoyl]pyrrolidine-1-carbonyl]pyrrolidin-1-yl]-4-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-2-oxoethyl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxopropan-2-yl]carbamoyl]-16-(2-amino-2-oxoethyl)-7,13-bis[(1R)-1-hydroxyethyl]-10-methyl-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicos-19-yl]amino]-1-oxohexan-2-yl]amino]-1-carboxy-4-oxobutyl]amino]-20-oxoicosanoic acid
Cagrilintide is a synthetic peptide analog designed to mimic and modulate the activity of the naturally occurring hormone amylin. As a member of the peptide compound class, it is structurally engineered to interact with amylin and calcitonin receptors, making it a valuable tool for probing metabolic pathways and neuroendocrine signaling mechanisms. Its unique molecular configuration offers enhanced stability and receptor selectivity compared to endogenous amylin, positioning it at the forefront of peptide-based research targeting appetite regulation, energy homeostasis, and glucose metabolism. The compound's biochemical properties have garnered significant interest within the fields of metabolic research, peptide pharmacology, and receptor biology, where it serves as a reference molecule for elucidating the physiological roles of amylin-related pathways.
Metabolic pathway investigation: Cagrilintide is frequently employed to study the intricate signaling networks that govern energy balance and glucose regulation. By serving as a selective agonist for amylin and calcitonin receptors, it enables researchers to dissect the downstream molecular events associated with satiety, insulin sensitivity, and nutrient partitioning. Experimental models utilizing this peptide provide critical insights into the modulation of appetite and the biochemical mechanisms underlying metabolic disorders, facilitating the identification of novel regulatory nodes within energy homeostasis.
Receptor pharmacology studies: The compound's high affinity for both amylin and calcitonin receptor complexes makes it an essential reagent in receptor binding and functional assays. Scientists use it to characterize receptor subtype selectivity, ligand-receptor interactions, and signal transduction pathways in cellular and tissue-based systems. These investigations help clarify the structural determinants of receptor activation and desensitization, supporting the rational design of next-generation peptide analogs with improved pharmacodynamic profiles.
Peptide structure-activity relationship (SAR) analysis: Cagrilintide's engineered sequence and conformational stability offer a robust framework for comparative SAR studies. Researchers utilize it to explore the relationship between specific amino acid modifications and biological activity, informing the optimization of peptide therapeutics and the development of novel analogs. Such investigations are instrumental in advancing the understanding of how structural features influence receptor binding, bioavailability, and in vivo efficacy in peptide-based drug discovery.
In vitro assay development: The compound is widely adopted as a reference standard or positive control in the development and validation of cell-based assays targeting amylin and related receptors. Its reproducible activity profile supports the establishment of quantitative assays for high-throughput screening, potency determination, and mechanistic evaluation of novel compounds. These applications are critical for accelerating the identification and characterization of new molecular entities in metabolic and neuroendocrine research pipelines.
Peptide stability and formulation research: Owing to its enhanced resistance to enzymatic degradation, cagrilintide serves as a model system for investigating peptide stabilization strategies and formulation approaches. Researchers leverage its properties to assess the impact of sequence modifications, excipients, and delivery systems on peptide integrity and biological activity. These studies contribute to the broader field of peptide drug development by informing best practices for improving the pharmacokinetic and physicochemical profiles of therapeutic peptides.
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