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Calcineurin Autoinhibitory Peptide

The peptide is a specific inhibitor for calcineurin phosphatase, and corresponds to the residues 467-491 within the inhibitory domain of human calcineurin alpha subunit. It inhibits Mn2+-stimulated calcineurin activity (IC50 = 10 uM using 32P-myosin light chain as substrate), but does not affect Ni2+-stimulated enzyme activity.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.

CAT No: R0845

CAS No:148067-21-4

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cGMP Peptide
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M.F/Formula
C124H205N39O39S2
M.W/Mr.
2930.34
Sequence
ITSFEEAKGLDRINERMPPRRDAMP
Labeling Target
Calcineurin
Appearance
White to off white powder
Purity
>98 %
Source#
Synthetic
Long-term Storage Conditions
Soluble in water
Solubility
-20 °C
InChI
InChI=1S/C124H205N39O39S2/c1-12-62(5)94(127)114(195)160-96(66(9)165)116(197)158-83(60-164)112(193)154-79(55-67-26-15-14-16-27-67)109(190)149-75(38-41-91(172)173)105(186)148-73(36-39-89(168)169)100(181)141-64(7)97(178)144-68(28-17-18-44-125)99(180)140-59-88(167)143-78(54-61(3)4)108(189)156-82(58-93(176)177)111(192)147-72(32-22-48-139-124(134)135)106(187)159-95(63(6)13-2)115(196)157-80(56-87(126)166)110(191)150-74(37-40-90(170)171)104(185)146-69(29-19-45-136-121(128)129)102(183)153-77(43-53-204-11)117(198)162-50-24-34-85(162)119(200)161-49-23-33-84(161)113(194)151-71(31-21-47-138-123(132)133)101(182)145-70(30-20-46-137-122(130)131)103(184)155-81(57-92(174)175)107(188)142-65(8)98(179)152-76(42-52-203-10)118(199)163-51-25-35-86(163)120(201)202/h14-16,26-27,61-66,68-86,94-96,164-165H,12-13,17-25,28-60,125,127H2,1-11H3,(H2,126,166)(H,140,180)(H,141,181)(H,142,188)(H,143,167)(H,144,178)(H,145,182)(H,146,185)(H,147,192)(H,148,186)(H,149,190)(H,150,191)(H,151,194)(H,152,179)(H,153,183)(H,154,193)(H,155,184)(H,156,189)(H,157,196)(H,158,197)(H,159,187)(H,160,195)(H,168,169)(H,170,171)(H,172,173)(H,174,175)(H,176,177)(H,201,202)(H4,128,129,136)(H4,130,131,137)(H4,132,133,138)(H4,134,135,139)/t62-,63-,64-,65-,66+,68-,69-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,94-,95-,96-/m0/s1
InChI Key
JRQDGUSHUYLSHC-TVQDNDAUSA-N
Isomeric SMILES
CC[C@H](C)[C@@H](C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCSC)C(=O)N2CCC[C@H]2C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCSC)C(=O)N4CCC[C@H]4C(=O)O)N
BoilingPoint
N/A
Melting Point
N/A

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