Calcitonin Gene Related Peptide (CGRP) II, Rat TFA is a long, amphipathic neuropeptide containing aromatic, charged, and helix-forming residues. Researchers study its conformational dynamics to model receptor engagement and peptide-membrane interactions. The trifluoroacetate form enhances solubility and handling. Applications include structure-function studies, ligand screening, and neuropeptide-motif analysis.
CAT No: R2586
CAS No:99889-63-1
Synonyms/Alias:H20705;CALCITONIN GENE RELATED PEPTIDE (CGRP) II, RAT TFA;99889-63-1;
Calcitonin gene related peptide (CGRP) II, rat TFA, is a synthetic peptide that mimics the endogenous neuropeptide CGRP found in rat species. It belongs to the family of calcitonin-related peptides, which are widely recognized for their roles in neuromodulation, vasodilation, and nociception. As a biologically active peptide, CGRP II is of significant interest in the exploration of neurovascular signaling, pain transmission pathways, and peptide-receptor interactions. Its sequence specificity and structural properties make it a valuable tool for dissecting the physiological and biochemical functions of CGRP isoforms in rodent models, supporting a broad range of research applications in neuroscience, vascular biology, and peptide pharmacology.
Neuroscience research: CGRP II serves as an essential probe for investigating the mechanisms of sensory neurotransmission and neurogenic inflammation within the central and peripheral nervous systems. Researchers utilize this peptide to study the activation and modulation of CGRP receptors, helping to elucidate the roles of CGRP in pain processing, migraine pathophysiology, and synaptic signaling. Its application in in vitro and in vivo models enables precise mapping of neuronal circuits and assessment of neuropeptide-mediated responses.
Vascular biology studies: Due to its potent vasodilatory effects, CGRP II is frequently employed in experiments designed to characterize vascular smooth muscle relaxation and endothelial function. By applying this peptide to isolated vessel preparations or cell-based assays, scientists can quantify vasomotor responses, analyze receptor subtype contributions, and explore the signaling pathways that govern vascular tone. Such studies are critical for advancing the understanding of blood flow regulation and the molecular basis of vascular disorders.
Peptide-receptor interaction assays: The high affinity of CGRP II for specific receptor complexes makes it a preferred ligand in binding studies and receptor activation assays. Researchers leverage its selectivity to delineate the pharmacology of CGRP receptor subtypes, assess ligand-receptor kinetics, and screen for novel antagonists or modulators. These applications are fundamental to drug discovery efforts targeting neuropeptide signaling pathways in preclinical models.
Peptide structure-function analysis: The availability of synthetic rat CGRP II enables detailed investigations into the structure-activity relationships of neuropeptides. By introducing sequence modifications or employing analogs, scientists can systematically evaluate the impact of specific residues on receptor binding, biological potency, and metabolic stability. Such work provides critical insights into peptide engineering, guiding the design of new research tools and potential therapeutic leads.
Analytical method development: CGRP II is often utilized as a reference standard or calibration peptide in the development and validation of analytical techniques, such as high-performance liquid chromatography (HPLC) and mass spectrometry. Its well-characterized properties facilitate accurate quantification, detection, and identification of peptide species in complex biological samples, supporting rigorous quality control and method optimization in peptide research laboratories.
1. The spatiotemporal control of signalling and trafficking of the GLP-1R
5. Adipose tissue is a key organ for the beneficial effects of GLP-2 metabolic function
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