Camstatin

Camstatin is an analog of PEP-19, and peptide antagonists of calmodulin.

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CAT#	R0878
CAS	1002295-95-5
Background	Camstatin is a similar PEP-19 analogue with enhanced calmodulin binding and antagonism. It is a functional 25-residue fragment of the IQ motif of PEP19 that binds to calmodulin and inhibits nitric oxide synthase in neurons. It defines the lowest active domain of PEP-19, and its binding affinity to calmodulin is positively correlated with its role as an inhibitor of nitric oxide synthase. >> Read More
M.F/Formula	C122H203N39O34
M.W/Mr.	2760.19
Sequence	APETERAAVAIQAQFRKFQKKKAGS-NH2
Labeling Target	Calmodulin
Appearance	White lyophilised solid
Purity	>99 %
Activity	Antagonist

Storage	-20°C
Long-term Storage Conditions	-20°C
InChI	InChI=1S/C122H203N39O34/c1-12-63(4)95(159-102(177)69(10)143-117(192)94(62(2)3)158-101(176)68(9)139-99(174)66(7)141-104(179)77(38-27-55-136-121(132)133)150-111(186)82(44-49-92(168)169)155-119(194)96(70(11)163)160-113(188)83(45-50-93(170)171)153-116(191)87-40-29-57-161(87)120(195)64(5)127)118(193)154-79(41-46-88(128)164)105(180)142-67(8)100(175)145-80(42-47-89(129)165)112(187)157-84(58-71-30-15-13-16-31-71)114(189)151-78(39-28-56-137-122(134)135)108(183)148-76(37-22-26-54-126)109(184)156-85(59-72-32-17-14-18-33-72)115(190)152-81(43-48-90(130)166)110(185)149-75(36-21-25-53-125)107(182)147-74(35-20-24-52-124)106(181)146-73(34-19-23-51-123)103(178)140-65(6)98(173)138-60-91(167)144-86(61-162)97(131)172/h13-18,30-33,62-70,73-87,94-96,162-163H,12,19-29,34-61,123-127H2,1-11H3,(H2,128,164)(H2,129,165)(H2,130,166)(H2,131,172)(H,138,173)(H,139,174)(H,140,178)(H,141,179)(H,142,180)(H,143,192)(H,144,167)(H,145,175)(H,146,181)(H,147,182)(H,148,183)(H,149,185)(H,150,186)(H,151,189)(H,152,190)(H,153,191)(H,154,193)(H,155,194)(H,156,184)(H,157,187)(H,158,176)(H,159,177)(H,160,188)(H,168,169)(H,170,171)(H4,132,133,136)(H4,134,135,137)/t63-,64-,65-,66-,67-,68-,69-,70+,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,94-,95-,96-/m0/s1
InChI Key	CZNWNBOOELGGSY-QCJADNLESA-N
Isomeric SMILES	CC[C@H](C)[C@@H](C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N)NC(=O)[C@H](C)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]3CCCN3C(=O)[C@H](C)N
References	Camstatin is a synthetic peptide (Pep-4, Table 2) modified from a sequence within PEP-19, a neuronal calmodulin-binding protein of unknown function, which includes the very basic IQ motif (commonly IQXXXRGXXXR) found in several proteins that bind calmodulin in the absence of Ca2+. Camstatin binds with similar affinity to calmodulin and Ca2+–calmodulin. A novel role for calmodulin: Ca2+-independent inhibition of type-1 inositol trisphosphate receptors

CAT#	Product Name	M.W	Molecular Formula	Inquiry
R0846	cGMP Dependent Kinase Inhibitor Peptide	943.12	C38H74N18O10	Inquiry
R0847	Bax inhibitor peptide, negative control	600.82	C28H52N6O6S	Inquiry
R0852	RAGE antagonist peptide	1272.56	C57H101N13O17S	Inquiry
R0855	G-Protein antagonist peptide	1093.27	C57H64N12O9S	Inquiry
R0856	Compstatin control peptide	1488.67	C66H101N23O17	Inquiry

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