CCZ01048 is a peptide-like research scaffold containing functional groups arranged to explore hydrogen bonding and hydrophobic contacts. Structural features support multiple rotamers and conformational states in solution. Researchers use it as a probe in binding screens and mechanistic assays. Applications cover early ligand discovery, structure-activity exploration, and computational-experimental correlation.
CAT No: R2855
Synonyms/Alias:CCZ01048; HY-P2336; CS-0130683; 2-[4-[2-[[1-[2-[[(2S)-1-[[(3S,6S,9R,12S,15S,23S)-9-benzyl-23-carbamoyl-6-[3-(diaminomethylideneamino)propyl]-12-(1H-imidazol-5-ylmethyl)-3-(1H-indol-3-ylmethyl)-2,5,8,11,14,17-hexaoxo-1,4,7,10,13,18-hexazacyclotricos-15-yl]amino]-1-oxohexan-2-yl]amino]-2-oxoethyl]piperidin-4-yl]amino]-2-oxoethyl]-7,10-bis(carboxymethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetic acid
CCZ01048 is a synthetic small molecule compound recognized for its utility in biochemical and pharmacological research settings. Characterized by its specific chemical structure and functional groups, this compound is designed to interact selectively with defined molecular targets, enabling researchers to probe intricate cellular mechanisms. Its structural attributes and stability make it an attractive tool for investigating signal transduction pathways, enzyme modulation, and molecular interactions within biological systems. As a research-use-only reagent, CCZ01048 holds significant relevance for laboratories seeking to elucidate mechanistic insights or validate hypotheses in areas such as molecular biology, chemical biology, and drug discovery.
Signal transduction research: CCZ01048 is frequently employed in studies focused on cellular signaling pathways. By acting as a modulator or probe of specific kinases, phosphatases, or receptor-associated proteins, it allows scientists to dissect the roles of these molecules in processes such as cell proliferation, differentiation, or apoptosis. The compound's selective binding characteristics facilitate the identification and characterization of downstream effectors, supporting the mapping of complex signaling networks in both normal and disease-related cellular contexts.
Enzyme inhibition assays: Researchers utilize CCZ01048 to evaluate its inhibitory or modulatory effects on target enzymes. Through in vitro biochemical assays, its application can help determine enzyme kinetics, substrate specificity, and competitive or non-competitive inhibition profiles. Such data are essential for understanding enzyme regulation and for the early-stage screening of potential drug candidates, as well as for elucidating the molecular underpinnings of enzymatic control within metabolic pathways.
Chemical probe development: The unique structural features of CCZ01048 make it an effective scaffold for the development of chemical probes. Scientists can use it as a starting point for structure-activity relationship (SAR) studies, enabling the rational design and optimization of analogs with improved potency, selectivity, or bioavailability. These efforts contribute to the creation of highly specific molecular tools for target validation, mechanistic studies, and high-content screening in chemical biology.
Target identification and validation: In functional genomics and proteomics, CCZ01048 serves as a valuable agent for target deconvolution and validation experiments. By selectively perturbing biological systems, it aids in uncovering the direct molecular targets and off-target profiles within complex proteomes. Such applications are critical for confirming the biological relevance of candidate targets and for minimizing unintended interactions in drug development pipelines.
Cell-based assay systems: The compound is also integrated into cell-based experimental platforms to monitor phenotypic outcomes following pathway modulation or enzyme inhibition. Its utility in these assays enables the assessment of cellular responses, including changes in gene expression, metabolic activity, or cytoskeletal dynamics. These insights are instrumental for bridging the gap between biochemical characterization and physiological relevance, supporting translational research and the advancement of new molecular tools for life science investigations.
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