Cemadotin, an omnipotent cytotoxic entity, is extensively employed in the mesmerizing biomedical realm to efficaciously combat an array of obstinate solid tumors encompassing pulmonary, mammary, as well as ovarian malignancies. Its extraordinary prowess lies within its exquisite ability to unequivocally pinpoint and curtail the polymerization of tubulin, thus imposing a profound halt upon the cell cycle, ultimately inducing apoptosis.
CAT No: R2050
CAS No:159776-69-9
Synonyms/Alias:Cemadotin;159776-69-9;Cemadotin [INN];cemadotina;cemadotine;UNII-6SQ8M7ZSFV;6SQ8M7ZSFV;LU 103793;NSC D-669356;NSC-D-669356;CEMADOTIN [WHO-DD];LU-103793;LU103793;N,N-dimethyl-L-valyl-L-valyl-N-methyl-L-valyl-L-prolyl-L-prolinebenzylamide;L-Prolinamide, N,N-dimethyl-L-valyl-L-valyl-N-methyl-L-valyl-L-prolyl-N-(phenylmethyl)-;NSCD-669356;cemadotinum;cemadotin free base;SCHEMBL18768;CHEMBL2104387;DTXCID6089214;NSC 669356D;NSC D669356;NSC-669356D;NSC-D669356;DA-72074;HY-13589;TS-09580;CS-0007296;Q27265457;N,N-Dimethyl-L-valyl-L-valyl-N-methyl-L-valyl-L-prolyl-N-benzyl-L-prolinamide;
Chemical Name:(2S)-N-benzyl-1-[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-(dimethylamino)-3-methylbutanoyl]amino]-3-methylbutanoyl]-methylamino]-3-methylbutanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carboxamide
Cemadotin is a synthetic antineoplastic compound belonging to the class of dolastatin analogs, characterized by its peptide-based structure and potent cytotoxic activity. As a synthetic peptide derivative, it is structurally related to natural marine peptides known for their ability to disrupt microtubule dynamics. Cemadotin's unique sequence and conformational attributes confer high specificity for tubulin binding, making it a valuable chemical tool in cellular and molecular biology research. Its well-defined mechanism of action and established role in modulating cytoskeletal architecture have positioned it as a compound of significant interest in the study of cell division, apoptosis, and microtubule-targeted drug design.
Antimitotic research: Cemadotin is widely utilized in studies investigating the mechanisms of mitotic inhibition. By binding to tubulin, it interferes with microtubule polymerization, thereby arresting cells in the G2/M phase of the cell cycle. This property makes it an essential reference compound for elucidating the molecular underpinnings of microtubule dynamics, spindle assembly, and the regulation of mitosis in both normal and transformed cells. Researchers leverage its activity to dissect the cellular checkpoints and pathways governing cell proliferation, contributing to a deeper understanding of cell cycle control.
Cytoskeletal studies: Due to its high affinity for tubulin, cemadotin serves as a valuable probe for analyzing microtubule structure and function. Its application in in vitro and cell-based assays enables precise manipulation of the cytoskeletal network, facilitating the study of microtubule-associated proteins, intracellular transport, and structural integrity of eukaryotic cells. Scientists employ cemadotin to investigate how alterations in microtubule stability impact cellular morphology, migration, and division, providing insights into cytoskeletal regulation and its implications in disease models.
Peptide drug development: The peptide-based framework of cemadotin offers a template for the rational design and optimization of novel tubulin-targeting agents. Medicinal chemists and peptide engineers use it as a lead compound for structure-activity relationship (SAR) studies, focusing on modifications that enhance selectivity, potency, and pharmacokinetic properties. Its synthetic accessibility and well-characterized bioactivity profile contribute to its role in the iterative development of next-generation antimitotic peptides and conjugates, supporting innovation in chemical biology and pharmaceutical research.
Apoptosis and cell death assays: Cemadotin is frequently employed in experimental systems to induce programmed cell death, allowing researchers to study apoptotic pathways and cellular responses to microtubule disruption. The compound's ability to trigger apoptosis via microtubule destabilization makes it a suitable tool for identifying key regulators of cell death, assessing the efficacy of apoptosis-modulating agents, and exploring resistance mechanisms in diverse cell types. Such studies are critical for advancing knowledge of cell fate decisions and the interplay between cytoskeletal integrity and survival signaling.
Combination therapy research: In preclinical investigations, cemadotin is often evaluated in combination with other chemical agents to assess synergistic or antagonistic effects on cellular viability and microtubule targeting. Its inclusion in combination studies supports the identification of compound interactions, optimization of dosing regimens, and elucidation of pathways that modulate sensitivity to antimitotic agents. By serving as a benchmark or adjunct in these studies, cemadotin aids in the development of more effective strategies for manipulating microtubule function and overcoming cellular resistance in research settings.
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