Cetrorelix Impurity 7 (+OH) Ditrifluoroacetate is an oxidized analogue featuring hydroxylation that alters polarity and retention behavior. Structural variation affects backbone geometry and hydrogen-bond potential. Researchers analyze it in impurity panels to validate chromatographic selectivity. Applications include QC profiling, degradation-pathway elucidation, and synthetic-route evaluation.
CAT No: Z10-101-172
CAS No:2901757-74-0 (free base)
Synonyms/Alias:((R)-2-((S)-2-((S)-2-((R)-2-((R)-2-((R)-2-acetamido-3-(naphthalen-2-yl)propanamido)-3-(4-chlorophenyl)propanamido)-3-(pyridin-3-yl)propanamido)-3-hydroxypropanamido)-3-(4-hydroxyphenyl)propanamido)-5-ureidopentanoyl)-L-leucyl-L-arginyl-L-prolyl-D-alanine , 2,2,2-trifluoroacetic acid (1:2)
Cetrorelix Impurity 7 (+OH) Ditrifluoroacetate is a specialized peptide derivative that plays a crucial role in the analytical and research sectors of peptide science. As a structurally distinct impurity related to the well-known gonadotropin-releasing hormone (GnRH) antagonist cetrorelix, this compound is characterized by the addition of a hydroxyl group and its formulation as a ditrifluoroacetate salt. The unique structure of Cetrorelix Impurity 7 (+OH) Ditrifluoroacetate makes it an invaluable reference material for scientists investigating the synthesis, stability, and purity of peptide-based pharmaceuticals. Its presence in analytical studies helps researchers understand potential byproducts or degradation products that may arise during peptide manufacturing or storage, aiding in the comprehensive profiling of cetrorelix and related compounds.
Analytical Method Development: In the context of analytical method development, Cetrorelix Impurity 7 (+OH) Ditrifluoroacetate serves as a critical standard for validating chromatographic and spectrometric techniques. Researchers utilize this impurity to optimize detection parameters, establish method sensitivity, and ensure accurate quantification of trace impurities in peptide formulations. By incorporating this compound into method validation protocols, laboratories can assess the selectivity and robustness of their analytical workflows, ultimately supporting the reliable identification and quantification of minor components in complex peptide samples.
Peptide Synthesis Quality Control: Quality control processes in peptide synthesis benefit greatly from the availability of Cetrorelix Impurity 7 (+OH) Ditrifluoroacetate as a reference impurity. During the production of cetrorelix and similar peptides, the formation of structurally related byproducts is a common challenge. The use of this impurity in quality control assays enables manufacturers to monitor and control impurity profiles, facilitating the optimization of synthesis protocols and purification steps. By benchmarking against known impurities, peptide chemists can minimize the presence of undesired variants and enhance the overall consistency of their products.
Degradation Pathway Elucidation: Understanding the degradation pathways of peptide pharmaceuticals is essential for ensuring their stability and shelf-life. The incorporation of Cetrorelix Impurity 7 (+OH) Ditrifluoroacetate into forced degradation studies allows researchers to simulate and characterize potential breakdown products under various stress conditions such as heat, light, or pH changes. By identifying and quantifying this impurity, scientists gain insight into the mechanisms of peptide degradation, which informs the development of improved formulation strategies and storage guidelines.
Pharmacological Research: In pharmacological research, the study of Cetrorelix Impurity 7 (+OH) Ditrifluoroacetate provides valuable information about the structure-activity relationships of peptide antagonists. By comparing the biological properties of cetrorelix and its impurities, researchers can discern the impact of specific structural modifications—such as hydroxylation—on receptor binding, metabolic stability, and functional activity. These investigations contribute to a deeper understanding of peptide pharmacology and may inspire the design of novel analogues with enhanced attributes for research purposes.
Reference Material for Regulatory Submissions: When preparing documentation for regulatory submissions or scientific publications, the use of well-characterized impurities like Cetrorelix Impurity 7 (+OH) Ditrifluoroacetate is essential for demonstrating the thoroughness of impurity profiling studies. Laboratories employ this compound as a reference material to support the identification and quantification of impurities in peptide drug substances and products. Its inclusion in analytical datasets enhances the credibility of research findings and facilitates transparent communication with regulatory agencies regarding the safety and quality of peptide-based therapeutics.
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