CGRP (rat) is a rat calcitonin gene-related peptide fragment featuring amphipathic residues critical for helix stabilization. The sequence enables studies of receptor-binding determinants and peptide-membrane interactions. Researchers examine its conformational dynamics in solution and mimetic environments. Its defined structure supports comprehensive biophysical investigations.
CAT No: R1859
CAS No:83651-90-5
Synonyms/Alias:CGRP (rat);83651-90-5;alpha-CGRP, rat;AKOS024456426;DA-79158;Alternative Name: Calcitonin Gene-Related Peptide (rat);
CGRP (rat), or Calcitonin Gene-Related Peptide specific to the rat species, is a neuropeptide of significant interest in neurobiology and vascular physiology research. As a member of the calcitonin peptide family, it is characterized by its potent vasodilatory properties and its role as a neurotransmitter and neuromodulator. The peptide is widely studied for its involvement in pain signaling, cardiovascular regulation, and neurogenic inflammation. Its functional significance in rat models makes it a valuable tool for elucidating species-specific physiological mechanisms and for advancing the understanding of peptide-mediated signaling pathways in mammals.
Neurophysiology research: In the context of neurophysiology, CGRP (rat) serves as a critical probe for investigating the molecular and cellular mechanisms underlying sensory neurotransmission. Its application in electrophysiological studies enables researchers to assess its effects on synaptic transmission, neuronal excitability, and the modulation of pain pathways. By applying the peptide to rat brain or spinal cord preparations, scientists can dissect its role in nociceptive processing and its interactions with other neuropeptides, thereby providing insights into the fundamental biology of sensory neurons.
Vascular biology studies: The peptide is extensively utilized in vascular biology to explore the regulation of blood vessel tone and endothelial function. Due to its robust vasodilatory action, it is employed in isolated vessel assays and in vivo rat models to characterize the mechanisms of smooth muscle relaxation and to delineate the downstream signaling cascades activated by CGRP receptors. These studies are pivotal for understanding the physiological control of blood flow, the pathophysiology of hypertension, and the contribution of neuropeptides to vascular homeostasis.
Migraine and pain research: CGRP (rat) is a cornerstone in preclinical models of migraine and pain, where it is used to induce and quantify migraine-like responses or to evaluate the efficacy of candidate therapeutics targeting the CGRP pathway. By administering the peptide in rat models, investigators can mimic key features of migraine pathogenesis, such as neurogenic inflammation and sensitization of trigeminal pathways. This application supports the development of novel pain modulators and enhances the translational relevance of animal studies in headache research.
Peptide receptor pharmacology: In receptor pharmacology, the rat-specific CGRP is instrumental for characterizing ligand-receptor interactions, signal transduction mechanisms, and the pharmacodynamics of CGRP antagonists or agonists. Utilizing radioligand binding assays, fluorescence-based detection, or functional cellular assays, researchers can quantify receptor affinity, efficacy, and downstream signaling events. Such studies inform the design of selective modulators and provide foundational data for drug discovery efforts targeting the CGRP system.
Peptide synthesis and analytical validation: The use of CGRP (rat) extends to peptide chemistry, where it serves as a reference standard or analyte in the synthesis, purification, and analytical characterization of neuropeptides. Its defined sequence and biological activity make it suitable for validating chromatographic methods, mass spectrometry protocols, and immunoassays tailored to neuropeptide quantification. These applications are essential for ensuring the quality and reproducibility of peptide-based reagents and for supporting the development of robust analytical workflows in neurochemical research.
If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at . We will endeavor to provide highly satisfying products and services.
Creative Peptides is a trusted CDMO partner specializing in high-quality peptide synthesis, conjugation, and manufacturing under strict cGMP compliance. With advanced technology platforms and a team of experienced scientists, we deliver tailored peptide solutions to support drug discovery, clinical development, and cosmetic innovation worldwide.
From custom peptide synthesis to complex peptide-drug conjugates, we provide flexible, end-to-end services designed to accelerate timelines and ensure regulatory excellence. Our commitment to quality, reliability, and innovation has made us a preferred partner across the pharmaceutical, biotechnology, and personal care industries.
Read More