Cibinetide is a synthetic 11-mer peptide that binds the tissue-protective receptor.
CAT No: R1855
CAS No:1208243-50-8
Synonyms/Alias:Cibinetide;1208243-50-8;ARA290;PHBSP;PH-BSP;ARA-290;Cibinetide [USAN];ARA 290;pHBSP peptide;Cibinetida;Pglu-glu-gln-leu-glu-arg-ala-leu-asn-ser-ser;9W5677JKDA;CIBINETIDE [INN];pyroglutamate helix B surface peptide;Pyr-glu-gln-leu-glu-arg-ala-leu-asn-ser-ser-OH;CIBINETIDE [WHO-DD];L-Pyroglutamyl-L-glutamyl-L-glutaminyl-L-ieucyl-L-glutamyl-L-arginyl-L-alanyl-L-leucyl-L-asparaginyl-L-seryl-L-serine;L-Pyroglutamyl-L-glutamyl-L-glutaminyl-L-leucyl-L-glutamyl-L-arginyl-L-alanyl-L-leucyl-L-asparaginyl-L-seryl-L-serine;pyroglutamate-glutamyl-glutaminyl-leucyl-glutamyl-arginyl-alanyl-leucyl-asparagyl-seryl-serine;L-Serine, 5-oxo-L-prolyl-L-alpha-glutamyl-L-glutaminyl-L-leucyl-L-alpha-glutamyl-L-arginyl-L-alanyl-L-leucyl-L-asparaginyl-L-seryl-;L-PYR-L-GLU-L-GLN-L-LEU-L-GLU-L-ARG-L-ALA-L-LEU-L-ASN-L-SER-L-SER;L-SERINE, 5-OXO-L-PROLYL-L-.ALPHA.-GLUTAMYL-L-GLUTAMINYL-L-LEUCYL-L-.ALPHA.-GLUTAMYL-L-ARGINYL-L-ALANYL-L-LEUCYL-L-ASPARAGINYL-L-SERYL-;UEQLERALNSS;cibinetidum;UNII-9W5677JKDA;Cibinetide (USAN/INN);GTPL9677;CHEMBL3545305;GLXC-26513;EX-A6264;AKOS040763919;DB13006;DA-71012;MS-32078;D11218;F85496;Q27273306;
Chemical Name:(4S)-5-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-4-amino-1-[[(2S)-1-[[(1S)-1-carboxy-2-hydroxyethyl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-5-oxo-4-[[(2S)-5-oxopyrrolidine-2-carbonyl]amino]pentanoic acid
Cibinetide is a synthetic peptide derived from the erythropoietin (EPO) molecule, engineered to selectively activate tissue-protective signaling pathways without stimulating erythropoiesis. As a member of the helix-B surface peptide family, it has garnered significant attention in the field of biochemical and cellular research due to its unique ability to engage the innate repair and anti-inflammatory mechanisms associated with the innate repair receptor (IRR). The compound's refined molecular structure enables researchers to dissect the non-hematopoietic functions of EPO, offering a valuable tool for investigating cell signaling, tissue protection, and molecular interactions in various experimental models.
Peptide signaling pathway studies: Cibinetide serves as a powerful probe for elucidating the non-erythropoietic signaling cascades initiated by EPO derivatives. By selectively targeting the IRR, it allows researchers to distinguish between classic EPO receptor-mediated pathways and those specifically involved in cytoprotection and anti-inflammatory responses. This specificity is instrumental in mapping downstream effectors and transcriptional regulators involved in tissue resilience and cellular integrity, facilitating a deeper understanding of peptide-mediated signal transduction in both in vitro and ex vivo systems.
Cellular stress and injury models: In experimental setups designed to mimic cellular stress, hypoxic conditions, or mechanical injury, Cibinetide is utilized to investigate mechanisms of tissue protection and repair. Its capacity to activate protective pathways without influencing red blood cell production makes it an ideal candidate for studying cellular responses to oxidative stress, apoptosis, and inflammation. Researchers employ the peptide to dissect the molecular events underlying cell survival, cytoskeletal stabilization, and the modulation of pro-survival gene expression in a variety of cell types, including neural, renal, and epithelial cells.
Inflammatory pathway research: The selective engagement of anti-inflammatory signaling by Cibinetide provides a targeted approach for exploring the modulation of cytokine networks and immune cell activity. Scientists leverage its unique receptor specificity to evaluate the suppression of pro-inflammatory mediators, such as TNF-α and IL-6, and to assess the peptide's influence on immune cell migration, adhesion, and activation. Such studies contribute to a refined understanding of how peptide-based agents can modulate inflammatory cascades without the confounding effects of hematopoietic stimulation.
Peptide-receptor interaction studies: The well-characterized binding properties of Cibinetide offer an excellent model for analyzing peptide-receptor interactions at the molecular level. Its interaction with the IRR can be probed using techniques such as surface plasmon resonance, co-immunoprecipitation, and site-directed mutagenesis, enabling the identification of critical binding domains and conformational changes upon ligand engagement. These insights are pivotal for the rational design of next-generation peptide therapeutics and for advancing the field of structure-activity relationship (SAR) studies.
Peptide synthesis and analog development: Due to its defined sequence and functional selectivity, Cibinetide is frequently employed as a reference compound in peptide chemistry and pharmaceutical research. It serves as a benchmark for the synthesis of novel EPO-mimetic peptides and analogs, facilitating the optimization of stability, receptor affinity, and bioactivity. Synthetic chemists and molecular pharmacologists utilize the peptide to validate synthetic strategies, assess the impact of sequence modifications, and guide the development of new biomolecules with tailored functional profiles for research applications.
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