Cibinetide

Cibinetide is a synthetic 11-mer peptide that binds the tissue-protective receptor.

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CAT No: R1855

CAS No: 1208243-50-8

Synonyms/Alias: Cibinetide;1208243-50-8;ARA290;PHBSP;PH-BSP;ARA-290;Cibinetide [USAN];ARA 290;pHBSP peptide;Cibinetida;Pglu-glu-gln-leu-glu-arg-ala-leu-asn-ser-ser;9W5677JKDA;CIBINETIDE [INN];pyroglutamate helix B surface peptide;Pyr-glu-gln-leu-glu-arg-ala-leu-asn-ser-ser-OH;CIBINETIDE [WHO-DD];L-Pyroglutamyl-L-glutamyl-L-glutaminyl-L-ieucyl-L-glutamyl-L-arginyl-L-alanyl-L-leucyl-L-asparaginyl-L-seryl-L-serine;L-Pyroglutamyl-L-glutamyl-L-glutaminyl-L-leucyl-L-glutamyl-L-arginyl-L-alanyl-L-leucyl-L-asparaginyl-L-seryl-L-serine;pyroglutamate-glutamyl-glutaminyl-leucyl-glutamyl-arginyl-alanyl-leucyl-asparagyl-seryl-serine;L-Serine, 5-oxo-L-prolyl-L-alpha-glutamyl-L-glutaminyl-L-leucyl-L-alpha-glutamyl-L-arginyl-L-alanyl-L-leucyl-L-asparaginyl-L-seryl-;L-PYR-L-GLU-L-GLN-L-LEU-L-GLU-L-ARG-L-ALA-L-LEU-L-ASN-L-SER-L-SER;L-SERINE, 5-OXO-L-PROLYL-L-.ALPHA.-GLUTAMYL-L-GLUTAMINYL-L-LEUCYL-L-.ALPHA.-GLUTAMYL-L-ARGINYL-L-ALANYL-L-LEUCYL-L-ASPARAGINYL-L-SERYL-;UEQLERALNSS;cibinetidum;UNII-9W5677JKDA;Cibinetide (USAN/INN);GTPL9677;CHEMBL3545305;GLXC-26513;EX-A6264;AKOS040763919;DB13006;DA-71012;MS-32078;D11218;F85496;Q27273306;

Chemical Name: (4S)-5-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-4-amino-1-[[(2S)-1-[[(1S)-1-carboxy-2-hydroxyethyl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-5-oxo-4-[[(2S)-5-oxopyrrolidine-2-carbonyl]amino]pentanoic acid

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Specification Technical Data Publications Customer reviews and Q&A
M.F/FormulaC51H84N16O21
M.W/Mr.1257.3
SequenceOne Letter Code:XEQLERALNSS
Three Letter Code:H-Pyr-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser-OH
ApplicationCibinetide has been used in trials studying the basic science of Depression.
AppearanceSolid powder
Purity> 98%
Long-term Storage ConditionsDMSO : ≥ 34 mg/mL (27.04 mM)
Shipping ConditionWet ice in continental US; may vary elsewhere
InChIInChI=1S/C51H84N16O21/c1-22(2)17-30(47(84)65-32(19-36(53)71)48(85)66-33(20-68)49(86)67-34(21-69)50(87)88)63-40(77)24(5)57-41(78)25(7-6-16-56-51(54)55)59-43(80)29(11-15-39(75)76)62-46(83)31(18-23(3)4)64-45(82)27(8-12-35(52)70)60-44(81)28(10-14-38(73)74)61-42(79)26-9-13-37(72)58-26/h22-34,68-69H,6-21H2,1-5H3,(H2,52,70)(H2,53,71)(H,57,78)(H,58,72)(H,59,80)(H,60,81)(H,61,79)(H,62,83)(H,63,77)(H,64,82)(H,65,84)(H,66,85)(H,67,86)(H,73,74)(H,75,76)(H,87,88)(H4,54,55,56)/t24-,25-,26-,27-,28-,29-,30-,31-,32-,33-,34-/m0/s1
InChI KeyWZTIQQBMSJTRBR-WYKNNRPVSA-N
Canonical SMILESCC(C)CC(C(=O)NC(CC(=O)N)C(=O)NC(CO)C(=O)NC(CO)C(=O)O)NC(=O)C(C)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCC(=O)O)NC(=O)C(CC(C)C)NC(=O)C(CCC(=O)N)NC(=O)C(CCC(=O)O)NC(=O)C1CCC(=O)N1
Isomeric SMILESC[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCC(=O)N1

1. Uncarboxylated osteocalcin decreases insulin-stimulated glucose uptake without affecting insulin signaling and regulators of mitochondrial biogenesis in myotubes

2. Multifunctional peptide-oligonucleotide conjugate promoted sensitive electrochemical biosensing of cardiac troponin I

3. Myotropic activity and immunolocalization of selected neuropeptides of the burying beetle Nicrophorus vespilloides (Coleoptera: Silphidae)

4. Olfactory receptor based piezoelectric biosensors for detection of alcohols related to food safety applications

5. An Open-label, Single-center, Safety and Efficacy Study of Eyelash Polygrowth Factor Serum

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