COG-1410 is a apolipoprotein E (apoE) peptide mimetic containing the amino acid sequence of the receptor-binding domain apoE.
CAT No: R1925
CAS No:878009-24-6
Synonyms/Alias:COG-1410;878009-24-6;UNII-0IEM5ZB8PU;0IEM5ZB8PU;L-Leucinamide, N-acetyl-L-alanyl-L-seryl-2-methylalanyl-L-leucyl-L-arginyl-L-lysyl-L-leucyl-2-methylalanyl-L-lysyl-L-arginyl-L-leucyl-;COG1410;AKOS040751235;Q27236820;
Chemical Name:(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-acetamidopropanoyl]amino]-3-hydroxypropanoyl]amino]-2-methylpropanoyl]amino]-4-methylpentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-6-amino-N-[(2S)-1-[[1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-2-methyl-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]hexanamide
COG-1410 is a synthetic peptide derived from apolipoprotein E (ApoE) mimetic sequences, engineered to retain the functional properties of the parent protein while offering enhanced stability and bioactivity in experimental settings. As a member of the ApoE-mimetic peptide family, it is characterized by its amphipathic helical structure and its ability to interact with lipid membranes and modulate cellular responses. COG-1410 has garnered significant attention in neurobiological and biochemical research due to its unique capacity to influence inflammatory pathways, oxidative stress, and cellular signaling processes. Its robust profile makes it a valuable tool for exploring mechanisms underlying neuroprotection, immune modulation, and peptide-membrane interactions in preclinical studies.
Neuroinflammation research: COG-1410 is frequently employed in studies investigating the molecular mechanisms of neuroinflammation. Its design enables it to modulate microglial activation and cytokine release, providing researchers with a means to dissect the intricate signaling pathways involved in neuroimmune responses. By serving as a functional analog of ApoE, the peptide allows for controlled manipulation of inflammatory cascades in in vitro and in vivo models, facilitating the identification of therapeutic targets and the elucidation of disease-associated molecular events.
Cell signaling pathway analysis: The peptide is widely utilized in the examination of key intracellular signaling pathways, particularly those related to oxidative stress and apoptosis. Due to its structural homology with regions of ApoE, COG-1410 can influence kinase activity, mitochondrial function, and transcriptional regulation within neural and immune cells. Researchers leverage these properties to investigate the cross-talk between lipid metabolism and cellular stress responses, advancing understanding of cell survival mechanisms under pathological conditions.
Peptide-membrane interaction studies: COG-1410 serves as an important model for studying peptide-lipid interactions due to its amphipathic nature and membrane-binding capabilities. Its sequence enables selective association with phospholipid bilayers, making it an effective probe for examining membrane dynamics, permeability alterations, and receptor-mediated uptake. These studies are essential for elucidating how peptide conformation and charge distribution affect biological activity and for optimizing peptide design in biotechnological applications.
Oxidative stress modulation: The compound is an effective tool for probing the effects of peptide-based interventions on oxidative stress parameters in neuronal and glial cell models. By mimicking critical aspects of ApoE function, COG-1410 has been shown to impact the production of reactive oxygen species and the regulation of antioxidant defense systems in experimental assays. Such applications are instrumental for researchers seeking to delineate the interplay between lipid-associated peptides and cellular redox balance.
Peptide drug discovery and optimization: COG-1410's well-characterized sequence and bioactivity profile make it a valuable template for the rational design and optimization of next-generation peptide therapeutics. Its structural and functional attributes provide a foundation for structure-activity relationship studies, high-throughput screening, and the development of novel peptide analogs with improved pharmacological properties. As a research tool, it supports efforts in peptide engineering and the exploration of innovative strategies for modulating protein-protein and protein-lipid interactions in diverse biomedical contexts.
1. Cell-based adhesion assays for isolation of snake venom’s integrin antagonists
4. SERS spectrum of the peptide thymosin‐β4 obtained with Ag nanorod substrate
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