Registration of APIs CMC information required for an IND
IND and NDA support Drug master files (DMF) filing
Application | T-cell assays, Immune monitoring, Antigen specific T-cell stimulation, T-cell expansion, Cellular immune response, Patient stratification, Qualification of immune responses |
Purity | >70% (HPLC-MS) |
Areas of Interest | Infection, Cancer, Hodgkin's lymphoma, Burkitt's lymphoma, Nasopharyngeal carcinoma, Dermatomyositis, Systemic lupus erythematosus, Rheumatoid arthritis, Sj?gren's syndrome, Multiple sclerosis |
Size | 2 aliquots of 13 peptide pools containing 1μg per peptide /tube |
Format | Freeze dried in micro tube rack with individual vials. |
NumberOfPeptides | 2043 |
Organism | Epstein-Barr virus (HHV-4) |
Specifications | Peptide scan (15mers with 11 aa overlap) |
Protein Name | Selected proteins |
References | 1."PepMixTM Peptide Pools for Clinical Applications: T cell therapy for viral infections after hematopoietic stem cell transplant" Leen et al, Application Note (2012) 2."T-cell Therapy for EBV-Associated Nasopharyngeal Carcinoma: Preparative Lymphodepleting Chemotherapy Does not Improve Clinical Results". Secondino et al., Ann. Onc. (2012) 3.Polyclonal B Cell Responses to Conserved Neutralization Epitopes in a Subset of HIV-1-Infected Individuals Tomaras et al., Journal of Virology (2011) 4."Effective and Long-term Control of EBV PTLD After Transfer of Peptide-Selected T Cells". Moosmann et al., BLOOD (2010) 5."Adoptive Transfer of EBV-specific T Cells Results in Sustained Clinical Responses in Patients With Locoregional Nasopharyngeal Carcinoma". Louis et al., J Immunother (2010) |
3. Low bone turnover and low BMD in Down syndrome: effect of intermittent PTH treatment
5. SERS spectrum of the peptide thymosin‐β4 obtained with Ag nanorod substrate
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