Copper Peptide (GHK)₂·Cu is a synthetic tripeptide-copper complex widely utilized in cosmetic formulations for its supportive role in skin care products. Known for its affinity to bind copper ions, this peptide is valued for its ability to help maintain skin's visible firmness and overall appearance. Suitable for a range of topical applications, Copper Peptide (GHK)₂·Cu is compatible with standard cosmetic ingredients and meets global regulatory requirements.
CAT No: CPC1658
Mechanism of Action (MOA)
Copper Peptide (GHK)₂·Cu is a biomimetic signal peptide complex that interacts with cellular pathways involved in skin homeostasis. Upon topical application, the GHK sequence has been shown to support the regulation of extracellular matrix components by modulating fibroblast activity and influencing the expression of key proteins such as collagen and glycosaminoglycans. The copper ion facilitates enzymatic processes associated with antioxidant defense and cellular communication, contributing to balanced skin physiology.
Copper Peptide (GHK)2·Cu is suitable for incorporation into a variety of personal care formulations.
- Facial serums and essences- Moisturizing creams and lotions- Eye contour products- Sheet masks and hydrogel patches- Scalp and hair care formulations- Post-procedure skin care products
Oxidative stress, disrupted copper homeostasis, and neuroinflammation due to overproduction of proinflammatory cytokines are considered leading causative factors in development of age-associated neurodegenerative conditions. Recently, a new mechanism of aging-detrimental epigenetic modifications-has emerged. Thus, compounds that possess antioxidant, anti-inflammatory activity as well as compounds capable of restoring copper balance and proper gene functioning may be able to prevent age-associated cognitive decline and ward off many common neurodegenerative conditions. The aim of this paper is to bring attention to a compound with a long history of safe use in wound healing and antiaging skin care. The human tripeptide GHK was discovered in 1973 as an activity in human albumin that caused old human liver tissue to synthesize proteins like younger tissue. It has high affinity for copper ions and easily forms a copper complex or GHK-Cu. In addition, GHK possesses a plethora of other regenerative and protective actions including antioxidant, anti-inflammatory, and wound healing properties. Recent studies revealed its ability to up- and downregulate a large number of human genes including those that are critical for neuronal development and maintenance. We propose GHK tripeptide as a possible therapeutic agent against age-associated neurodegeneration and cognitive decline.
Pickart, L., Vasquez-Soltero, J. M., & Margolina, A. (2012). The human tripeptide GHK-Cu in prevention of oxidative stress and degenerative conditions of aging: implications for cognitive health. Oxidative medicine and cellular longevity, 2012.
1. SERS spectrum of the peptide thymosin‐β4 obtained with Ag nanorod substrate
2. TMEM16F and dynamins control expansive plasma membrane reservoirs
4. Adipose tissue is a key organ for the beneficial effects of GLP-2 metabolic function
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