CRF, bovine is a potent agonist of CRF receptor, and displaces [125I-Tyr]ovine CRF with a Ki of 3.52 nM.
CAT No: R1306
CAS No:92307-52-3
Synonyms/Alias:92307-52-3;Corticotropin Releasing Factor bovine;CRF (bovine) trifluoroacetate salt;DTXSID80856168;PUBCHEM_71581479;DA-52133;
Corticotropin-Releasing Factor, bovine (CRF, bovine) is a synthetic peptide corresponding to the naturally occurring neuropeptide found in bovine species. As a pivotal component of the hypothalamic-pituitary-adrenal (HPA) axis, CRF orchestrates the body's response to stress by stimulating the secretion of adrenocorticotropic hormone (ACTH) from the anterior pituitary. Its well-characterized structure and conserved sequence among mammals make it a valuable tool for dissecting neuroendocrine signaling pathways, investigating receptor pharmacology, and modeling stress-related physiological processes in vitro and in vivo. The availability of bovine CRF in research-grade form enables scientists to explore its diverse roles in cellular communication, neurobiology, and endocrine regulation.
Neuroendocrine research: CRF, bovine serves as a fundamental reagent for elucidating the mechanisms governing the HPA axis. By applying this peptide to cultured pituitary cells or hypothalamic explants, researchers can precisely stimulate ACTH release, facilitating studies of feedback regulation, receptor specificity, and intracellular signaling cascades. Its use is instrumental in mapping the molecular events underlying stress hormone synthesis and secretion, providing insights into the neuroendocrine integration of physiological stress responses.
Receptor binding studies: The peptide is widely utilized for characterizing CRF receptor subtypes and their pharmacological properties. Through radioligand binding assays or competitive displacement experiments, investigators can quantify receptor affinity, selectivity, and downstream signaling kinetics. Bovine CRF's high degree of homology with endogenous mammalian CRF ensures reliable interaction with human and rodent CRF receptors, making it a robust standard for comparative pharmacological profiling and antagonist screening.
Peptide structure-function analysis: As a well-defined synthetic neuropeptide, CRF, bovine is frequently employed in structure-activity relationship (SAR) studies. By introducing site-specific modifications or generating analogs, scientists can assess the impact of sequence alterations on receptor activation, biological potency, and metabolic stability. These investigations are crucial for advancing peptide engineering, optimizing ligand-receptor interactions, and designing novel CRF-based probes for neurobiological research.
Stress physiology modeling: In experimental models, exogenous administration of CRF, bovine enables controlled induction of stress-like endocrine responses. Researchers leverage this approach to simulate acute or chronic stress conditions in animal studies or cell-based assays, thereby dissecting the molecular and systemic consequences of HPA axis activation. Such models support the investigation of stress-related gene expression, neuroimmune interactions, and adaptive physiological changes, contributing to a deeper understanding of homeostatic regulation.
Peptide assay development: The biochemical stability and defined activity of CRF, bovine make it an ideal calibrator and positive control in immunoassays and bioassays designed to quantify CRF or ACTH levels. Its application ensures assay reliability, reproducibility, and sensitivity, supporting the accurate measurement of neuropeptide concentrations in complex biological samples. This utility is particularly valuable in the validation of new analytical platforms and the standardization of neuroendocrine research protocols.
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