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A potent and selective αVβ3 integrin inhibitor with an IC50 of 20 nM.
CAT No: R1823
CAS No: 217099-14-4
Synonyms/Alias: 217099-14-4;Cyclo(RGDyK);cyclo[Arg-Gly-Asp-D-Tyr-Lys];Cyclo(-Arg-Gly-Asp-D-Tyr-Lys) trifluoroacetate salt;CHEMBL2071605;2-[(2S,5R,8S,11S)-8-(4-aminobutyl)-11-[3-(diaminomethylideneamino)propyl]-5-[(4-hydroxyphenyl)methyl]-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentazacyclopentadec-2-yl]acetic acid;cyclo(Arg-Gly-Asp-D-Tyr-Lys);cyclo-(Arg-Gly-Asp-d-Tyr-Lys);cyclo-[Arg-Gly-Asp-d-Tyr-Lys];Cyclo(L-arginylglycyl-L-|A-aspartyl-D-tyrosyl-L-lysyl);SCHEMBL7746029;BDBM50390492;AT42662;HY-100563A;DA-52216;FC110223;CS-0100470;
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M.F/Formula | C27H41N9O8 |
M.W/Mr. | 619.7 |
Sequence | Three Letter Code:cyclo[Arg-Gly-Asp-D-Tyr-Lys] |
Purity | >98 % |
Areas of Interest | Cancer Research |
Source# | Synthetic |
Long-term Storage Conditions | 10 mM in DMSO |
Shipping Condition | Shipped at room temperature |
InChI | InChI=1S/C27H41N9O8/c28-10-2-1-4-18-24(42)34-17(5-3-11-31-27(29)30)23(41)32-14-21(38)33-20(13-22(39)40)26(44)36-19(25(43)35-18)12-15-6-8-16(37)9-7-15/h6-9,17-20,37H,1-5,10-14,28H2,(H,32,41)(H,33,38)(H,34,42)(H,35,43)(H,36,44)(H,39,40)(H4,29,30,31)/t17-,18-,19+,20-/m0/s1 |
InChI Key | LAROZEWEPNAWMD-HAGHYFMRSA-N |
2. The spatiotemporal control of signalling and trafficking of the GLP-1R
3. TMEM16F and dynamins control expansive plasma membrane reservoirs
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