Cyclo(His-Pro) forms a diketopiperazine ring uniting histidine and proline in a compact cyclic scaffold. The imidazole side chain contributes metal-binding and acid-base properties, while proline enforces conformational rigidity. Researchers use it as a model for endogenous cyclic dipeptides and neuromodulatory motifs. Applications span food chemistry, neurobiochemistry, and cyclic-peptide structure studies.
CAT No: R2707
CAS No:53109-32-3
Synonyms/Alias:Cyclo(his-pro);Cyclo(-His-Pro);53109-32-3;Cyclo(L-His-L-Pro);UNII-Q10817UXVT;Q10817UXVT;L-His-L-Pro-DKP;L,L-cyclo(histidylprolyl);Cyclo(L-histidyl-L-proline);MLS000028694;CHEBI:90039;CYCLO-(L-HISTIDINE-L-PROLINE) INHIBITOR;SMR000058881;(3S,8aS)-3-(1H-Imidazol-4-ylmethyl)hexahydropyrrolo[1,2-a]pyrazine-1,4-dione;(3S,8aS)-3-[(1H-imidazol-5-yl)methyl]hexahydropyrrolo[1,2-a]pyrazine-1,4-dione;(3S,8AS)-3-(1H-IMIDAZOL-5-YLMETHYL)-2,3,6,7,8,8A-HEXAHYDROPYRROLO(1,2-A)PYRAZINE-1,4-DIONE;(3S,8aS)-3-((1H-imidazol-5-yl)methyl)-octahydropyrrolo(1,2-a)pyrazine-1,4-dione;(3S,8aS)-3-((1H-imidazol-5-yl)methyl)hexahydropyrrolo(1,2-a)pyrazine-1,4-dione;(3S,8aS)-3-(1H-Imidazol-4-ylmethyl)hexahydropyrrolo(1,2-a)pyrazine-1,4-dione;(3S,8aS)-3-[(1H-imidazol-5-yl)methyl]-octahydropyrrolo[1,2-a]pyrazine-1,4-dione;MFCD00133207;1w1t;Opera_ID_1205;Cyclo(histidyl-proline);Histidylproline diketopiperazine;cyclo[l-histidyl-l-prolyl];CHEMBL188225;SCHEMBL2039884;SCHEMBL12228287;DTXSID90962567;(3S,8aS)-3-((1H-imidazol-4-yl)methyl)hexahydropyrrolo[1,2-a]pyrazine-1,4-dione;HMS2234D12;CS-6320;DB02414;FC49257;(3S,8AR)-3-(1H-IMIDAZOL-5-YLMETHYL)HEXAHYDROPYRROLO[1,2-A]PYRAZINE-1,4-DIONE;HY-101402;NS00069934;G85416;Q27286866;(3S,8aS)-3-(1H-imidazol-5-ylmethyl)hexahydropyrrolo[1,2-a]pyrazine-1,4-dione;
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