Cyclo-(L-Pro-L-Ile) is a diketopiperazine ring formed by cyclization of proline and isoleucine, producing a rigid scaffold with constrained backbone geometry. The bicyclic core enhances stability and modulates hydrophobic interactions. Researchers use it to explore β-turn mimicry, ligand-protein contacts, and conformation-dependent dynamics. Its compact structure supports detailed mechanistic and biophysical studies.
CAT No: R2279
CAS No:57089-60-8
Synonyms/Alias:57089-60-8;Cyclo-(L-Pro-L-Ile);Cyclo(Ile-Pro);cyclo(isoleucyl-prolyl);CHEMBL499545;BDBM163708;Cyclo L-Pro-L-Ile (Fr. 1-5);ARD183733;AKOS040734722;FC165819;1ST183733;(3S,8aS)-3-((S)-sec-Butyl)hexahydropyrrolo[1,2-a]pyrazine-1,4-dione;(3S,8aS)-3-[(2S)-butan-2-yl]-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione;(3S,8aS)-3-[(2S)-butan-2-yl]-2,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione;
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