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Cyclo(-Leu-Pro)

Cyclo(-Leu-Pro) is a cyclic dipeptide containing leucine and proline. Cyclo(L-Leu-L-Pro) is a homodetic cyclic peptide composed from leucyl and prolyl residues. It has a role as a marine metabolite and a bacterial metabolite. It is a dipeptide, a homodetic cyclic peptide and a pyrrolopyrazine.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.
Cyclo(-Leu-Pro)(CAS 2873-36-1)

CAT No: R1915

CAS No:2873-36-1

Synonyms/Alias:2873-36-1;Cyclo(-Leu-Pro);cyclo(L-leu-L-pro);Gancidin W;(3S,8aS)-3-Isobutylhexahydropyrrolo[1,2-a]pyrazine-1,4-dione;cyclo(Leu-Pro);Cyclo(L-prolyl-L-leucyl);Cyclo-L-leu-L-pro;Cyclo(L-leucyl-L-prolyl);L-Leucyl-L-proline lactam;L-cyclo(Leu-pro);L-cyclo(Leucyloprolyl);L,L-Cyclo(leucylprolyl);Pyrrolo[1,2-a]pyrazine-1,4-dione, hexahydro-3-(2-methylpropyl)-, (3S,8aS)-;(3S,8aS)-3-(2-methylpropyl)-2,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione;Maculosin 6;Cyclo(leucyl-prolyl);Cyclo(L-Pro-L-Leu);KQV8MY059B;SZJNCZMRZAUNQT-IUCAKERBSA-N;MFCD00237617;cyclo-(L-Pro-L-Leu);Cyclo(-L-Leu-L-Pro);Cyclo(-L-leucyl-prolyl);CHEMBL508326;SCHEMBL2037800;DTXSID80951384;CHEBI:133094;BDBM163709;HY-P1939;Cyclo L-Pro-L-Leu (Fr. 1-6);AKOS024463311;FC20681;AS-40794;DA-72469;CS-0065365;NS00049404;EN300-28258032;(3S,8aS)-3-(2-methylpropyl)hexahydropyrrolo[1,2-a]pyrazine-1,4-dione;(3S,8AS)-3-(2-METHYLPROPYL)-HEXAHYDROPYRROLO[1,2-A]PYRAZINE-1,4-DIONE;(3S,8aS)-3-isobutyl-2,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione;rac-(3R,8aR)-3-(2-methylpropyl)-octahydropyrrolo[1,2-a]pyrazine-1,4-dione;(3S-trans)-Hexahydro-3-(2-methylpropyl)-pyrrolo[1,2-a]pyrazine-1,4-dione;3-Isobutylhexahydropyrrolo [1,2-a] pyrazine-1,4-dione;Cyclo (L-leu-L-pro);

Chemical Name:(3S,8aS)-3-(2-methylpropyl)-2,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione

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M.F/Formula
C11H18N2O2
M.W/Mr.
210.27
Application
Antimicrobial & Antiviral Peptides; Obesity Research
Activity
Antimicrobial cyclopeptide
Biological Activity
Cyclo(Leu-Pro) showed antibacterial activity. Yan et al. observed that Cyclo(Leu-Pro) produced by Achromobacter xylosoxidans inhibited aflatoxin production by Aspergillus parasiticus. The diketopiperazine was shown to inhibit catecholamine release in vitro. It could play a role in the hypothalamic modulation of appetite suppressant circuitry.
Long-term Storage Conditions
Soluble in DMSO
Shipping Condition
Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
InChI
InChI=1S/C11H18N2O2/c1-7(2)6-8-11(15)13-5-3-4-9(13)10(14)12-8/h7-9H,3-6H2,1-2H3,(H,12,14)/t8-,9-/m0/s1
InChI Key
SZJNCZMRZAUNQT-IUCAKERBSA-N
Canonical SMILES
CC(C)CC1C(=O)N2CCCC2C(=O)N1
Isomeric SMILES
CC(C)C[C@H]1C(=O)N2CCC[C@H]2C(=O)N1

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