(D-Ala2)-Gastric Inhibitory Polypeptide (human) Trifluoroacetate Salt includes a stereochemical substitution that alters backbone geometry and enzymatic recognition. Researchers investigate its folding patterns and structural adaptability. The peptide supports motif-specific binding studies. Applications include structural mapping, peptide-analog engineering, and biophysical evaluation.
CAT No: R2486
CAS No:444073-04-5
Synonyms/Alias:(D-Ala2)-Gastric Inhibitory Polypeptide (human) trifluoroacetate salt;444073-04-5;(D-Ala2)-Gastric Inhibitory Polypeptide (human) trifluoroacetate salt;(D-Ala2)-Gastric Inhibitory Polypeptide (human) trifluoroacetate salt H-Tyr-D-Ala-Glu-Gly-Thr-Phe-Ile-Ser-Asp-Tyr-Ser-Ile-Ala-Met-Asp-Lys-Ile-His-Gln-Gln-Asp-Phe-Val-Asn-Trp-Leu-Leu-Ala-Gln-Lys-Gly-Lys-Lys-Asn-Asp-Trp-Lys-His-Asn-Ile-Thr-Gln-OH trifluoroacetate salt;DA-69130;
(D-Ala2)-Gastric Inhibitory Polypeptide (human) trifluoroacetate salt is a synthetic peptide analog of the naturally occurring human gastric inhibitory polypeptide (GIP), modified with a D-alanine residue at position 2. This modification enhances the peptide's resistance to enzymatic degradation, thereby increasing its stability in experimental settings. As a potent incretin mimetic, (D-Ala2)-GIP is widely used in research focused on metabolic regulation, hormone signaling, and peptide-receptor interactions. The trifluoroacetate salt form ensures improved solubility and ease of handling for a variety of laboratory applications. Researchers value this analog for its ability to selectively engage GIP receptors, enabling detailed studies of downstream biological effects without rapid breakdown by dipeptidyl peptidase-IV (DPP-IV).
Metabolic Research: In metabolic studies, (D-Ala2)-GIP plays a pivotal role in elucidating the mechanisms of glucose homeostasis and energy balance. The analog is commonly used to investigate how GIP signaling influences insulin secretion from pancreatic beta cells, providing insights into the regulation of postprandial blood glucose levels. Its increased stability allows for prolonged activity in in vitro and in vivo experiments, facilitating the assessment of incretin effects on glucose metabolism over extended periods. This makes it an invaluable tool for dissecting the complex interplay between gut hormones and pancreatic function, especially in models of obesity and type 2 diabetes.
Receptor Pharmacology: For receptor pharmacology research, the D-Ala2-modified peptide serves as a selective agonist for the GIP receptor (GIPR), enabling detailed characterization of receptor binding, activation, and downstream signaling pathways. Scientists utilize this analog to map the structural requirements for receptor interaction and to distinguish between GIPR-mediated effects and those triggered by related peptides such as GLP-1. The peptide's resistance to rapid enzymatic cleavage ensures consistent receptor engagement, which is critical for identifying key determinants of ligand specificity and efficacy in both cell-based assays and animal models.
Peptide Stability Studies: The enhanced proteolytic stability of (D-Ala2)-GIP makes it an excellent model for studying peptide degradation and the impact of amino acid substitutions on peptide lifespan. Researchers employ this analog to compare degradation rates against native GIP, providing valuable information on how specific modifications can extend peptide half-life. These insights inform the rational design of next-generation peptide therapeutics with improved pharmacokinetic properties, guiding the development of more effective and durable drug candidates for metabolic disorders.
Signal Transduction Analysis: In the field of signal transduction, the analog is used to probe intracellular pathways activated by GIPR engagement. By applying (D-Ala2)-GIP to cultured cells or tissue preparations, scientists can monitor changes in cyclic AMP production, kinase activation, and gene expression profiles. This approach helps clarify the molecular mechanisms underlying incretin hormone action, shedding light on how GIP modulates cellular responses in target tissues such as the pancreas, adipose tissue, and brain. The peptide's consistent activity profile supports reproducible results in these complex signaling studies.
Endocrine System Research: Within endocrine system investigations, (D-Ala2)-GIP trifluoroacetate salt is leveraged to explore the broader physiological roles of GIP beyond glucose regulation. Researchers examine its effects on lipid metabolism, appetite control, and bone remodeling, using the peptide to dissect the hormone's influence on various organ systems. The analog's stability and selectivity make it particularly useful for delineating GIP's contribution to endocrine crosstalk and for identifying novel therapeutic targets in metabolic and hormonal disorders. Its application in these multifaceted studies continues to advance our understanding of gut-derived peptide hormones and their systemic impacts.
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