(Des-Ala3)-GHRP-2 features a modified peptide backbone that helps clarify structure-activity relationships in receptor-binding systems. Removal of alanine alters local geometry and hydrogen-bond patterns. Researchers explore its conformational changes and binding preferences. Applications include peptide analog design, structural analysis, and motif-function exploration.
CAT No: R2640
CAS No:290312-22-0
Synonyms/Alias:(des-ala3)-ghrp-2;290312-22-0;(2S)-6-amino-2-[[(2R)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-aminopropanoyl]amino]-3-naphthalen-2-ylpropanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-phenylpropanoyl]amino]hexanamide;MFCD00671440;H-D-Ala-D-2-Nal-Trp-D-Phe-Lys-NH2;Pralmorelin trifluoroacetate salt;HY-P4409;CCG-270430;DA-59549;FD108699;CS-0653931;
(Des-ala3)-ghrp-2 is a synthetic peptide analog derived from the growth hormone-releasing peptide family, specifically designed by removing the alanine residue at the third position. This structural modification imparts unique biochemical properties, distinguishing it from its parent compound, GHRP-2, and enabling targeted applications in scientific research. As a hexapeptide, (Des-ala3)-ghrp-2 demonstrates high stability and affinity for its receptors, making it a valuable tool for investigating complex physiological pathways. Its robust profile allows researchers to explore peptide-receptor interactions, intracellular signaling cascades, and metabolic responses with greater specificity. The versatility of this compound has led to its adoption in a range of experimental models, from in vitro cell cultures to in vivo animal studies, where it serves as a critical probe for understanding peptide-mediated processes.
Endocrine Research: In the field of endocrine research, (Des-ala3)-ghrp-2 is utilized to dissect the molecular mechanisms regulating growth hormone secretion. By binding to the growth hormone secretagogue receptor (GHS-R), it stimulates the release of endogenous growth hormone in a controlled laboratory setting. This property allows scientists to study the downstream effects of growth hormone on metabolism, tissue growth, and cellular proliferation, providing insights into endocrine system regulation and potential dysregulation in various physiological and pathological states.
Appetite Regulation Studies: As an analog of GHRP-2, (Des-ala3)-ghrp-2 is frequently employed in appetite regulation studies. Its interaction with hypothalamic pathways enables researchers to examine the central and peripheral mechanisms controlling food intake and energy balance. Through these investigations, the peptide helps elucidate the roles of ghrelin and related neuropeptides in appetite modulation, offering a deeper understanding of metabolic disorders such as obesity and cachexia.
Signal Transduction Analysis: The unique structure of (Des-ala3)-ghrp-2 makes it a powerful tool for analyzing G-protein coupled receptor (GPCR) signaling. By serving as a selective agonist, it facilitates the mapping of intracellular pathways activated upon receptor engagement. Researchers can monitor the activation of second messengers, phosphorylation events, and gene expression changes, thereby unraveling the intricate networks that govern cellular responses to peptide hormones. This mechanistic knowledge is essential for advancing basic science and informing the design of novel therapeutic agents.
Pharmacological Profiling: In pharmacological studies, (Des-ala3)-ghrp-2 is instrumental in characterizing the binding affinity, selectivity, and efficacy of receptor-ligand interactions. It is used to compare the functional properties of various peptide analogs, assess competitive inhibition, and determine structure-activity relationships. These experiments contribute to the optimization of peptide-based modulators for research applications, supporting the development of more effective compounds for probing biological systems.
Metabolic Research: Scientists investigating metabolic regulation often leverage (Des-ala3)-ghrp-2 to probe the effects of growth hormone secretagogues on glucose and lipid metabolism. Its ability to modulate hormone release and energy homeostasis provides a model for studying the interplay between endocrine signals and metabolic outcomes. By incorporating this peptide into metabolic assays, researchers gain valuable data on how peptide hormones influence nutrient uptake, storage, and utilization, which is fundamental for understanding metabolic health and disease.
Neuroendocrinology: The application of (Des-ala3)-ghrp-2 extends to neuroendocrinology, where it serves as a probe for investigating the crosstalk between the nervous and endocrine systems. By modulating neuropeptide signaling in the brain, it aids in the exploration of stress responses, circadian rhythms, and neuroendocrine feedback loops. These studies are vital for uncovering the neural substrates of hormone action and their broader implications for behavior and physiology, reinforcing the significance of this peptide in advancing neuroscience and endocrinology research.
1. An Open-label, Single-center, Safety and Efficacy Study of Eyelash Polygrowth Factor Serum
2. Adipose tissue is a key organ for the beneficial effects of GLP-2 metabolic function
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