(Des-Ala3)-GHRP-2 features a modified peptide backbone that helps clarify structure-activity relationships in receptor-binding systems. Removal of alanine alters local geometry and hydrogen-bond patterns. Researchers explore its conformational changes and binding preferences. Applications include peptide analog design, structural analysis, and motif-function exploration.
CAT No: R2640
CAS No:290312-22-0
Synonyms/Alias:(des-ala3)-ghrp-2;290312-22-0;(2S)-6-amino-2-[[(2R)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-aminopropanoyl]amino]-3-naphthalen-2-ylpropanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-phenylpropanoyl]amino]hexanamide;MFCD00671440;H-D-Ala-D-2-Nal-Trp-D-Phe-Lys-NH2;Pralmorelin trifluoroacetate salt;HY-P4409;CCG-270430;DA-59549;FD108699;CS-0653931;
(Des-ala3)-ghrp-2 is a synthetic peptide analogue derived from the growth hormone-releasing peptide-2 (GHRP-2) sequence, characterized by the specific removal of the alanine residue at position three. As a modified hexapeptide, it is designed to probe the structure-activity relationships within the ghrelin receptor (GHS-R1a) signaling pathway. Its unique sequence alteration offers researchers a valuable tool for dissecting the molecular mechanisms underlying peptide-receptor interactions and for investigating the physiological roles of growth hormone secretagogues in cellular and biochemical systems.
Receptor Binding Studies: One of the primary research applications of (Des-ala3)-ghrp-2 lies in its use as a ligand for the ghrelin receptor in binding assays. The selective modification in its structure allows for detailed exploration of how specific amino acid residues contribute to receptor affinity and activation. By comparing the binding characteristics of this peptide variant with those of native GHRP-2 and other analogues, scientists can elucidate the critical determinants involved in receptor-ligand specificity and downstream signaling events.
Peptide Structure-Activity Relationship (SAR) Analysis: The compound is highly relevant for SAR investigations focused on growth hormone secretagogue peptides. Researchers utilize (Des-ala3)-ghrp-2 to systematically assess the impact of targeted amino acid deletions on biological activity, receptor engagement, and conformational stability. These studies provide foundational insights that inform the rational design of next-generation peptides with optimized efficacy, selectivity, and pharmacological properties for research use.
Intracellular Signaling Pathway Elucidation: In cellular models expressing the ghrelin receptor, this peptide serves as a probe for dissecting the intracellular signaling cascades triggered by receptor activation. By monitoring changes in second messenger systems, such as calcium flux or cAMP levels, upon exposure to (Des-ala3)-ghrp-2, investigators can map the downstream pathways and identify potential modulators or regulatory checkpoints within the growth hormone secretagogue axis.
Peptide Synthesis and Analytical Method Development: The defined structure of (Des-ala3)-ghrp-2 makes it a valuable reference compound in peptide synthesis optimization and analytical validation. It is frequently employed to assess the performance of solid-phase peptide synthesis protocols, chromatographic purification strategies, and mass spectrometric detection methods. Its use as a standard supports quality control and method development in research laboratories focused on peptide chemistry.
Biochemical Assays of Growth Hormone Secretagogue Function: The peptide is also incorporated into in vitro biochemical assays designed to evaluate the functional consequences of structural modifications within the GHRP family. Through comparative studies of secretagogue activity, receptor desensitization, and peptide stability, it enables a deeper understanding of the molecular features that govern bioactivity and degradation pathways, thereby informing future research directions in peptide-based signaling systems.
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