Dihexa is a small peptide that has been developed to potently improve certain cognitive function of potential trauma-based brain disorders and neurodegenerative conditions through increased synaptogenesis.
CAT No: 10-101-343
CAS No:1401708-83-5
Synonyms/Alias:dihexa;1401708-83-5;L-Isoleucinamide, N-(1-oxohexyl)-L-tyrosyl-N-(6-amino-6-oxohexyl)-;N-hexanoic-Tyr-Ile-(6) aminohexanoic amide;9WYX65A5C2;PNB-0408;(2S,3S)-N-(6-amino-6-oxohexyl)-2-[[(2S)-2-(hexanoylamino)-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanamide;6-(2-(2-Hexanamido-3-(4-hydroxyphenyl)propanamido)-3-methylpentanamido)hexanamide;6-[(2S,3S)-2-[(2S)-2-hexanamido-3-(4-hydroxyphenyl)propanamido]-3-methylpentanamido]hexanamide;Hexanoyl-Tyr-Ile-Ahx-NH2;UNII-9WYX65A5C2;Dihexa (PNB-0408)?;DTXSID701032895;GLXC-25923;ATH-1001;AKOS040759118;CS-6864;DA-62870;HY-16969;PNB-0408; Hexanoyl-Tyr-Ile-Ahx-NH2;TS-09667;H20471;N-(1-OXOHEXYL)-L-TYROSYL-N-(6-AMINO-6-OXOHEXYL)-L-ISOLEUCINAMIDE;
Chemical Name:(2S,3S)-N-(6-amino-6-oxohexyl)-2-[[(2S)-2-(hexanoylamino)-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanamide
Dihexa, also known as N-hexanoic-Tyr-Ile-(6) aminohexanoic amide, is a synthetic oligopeptide designed to enhance cognitive function and promote neural health. Developed through rational drug design, Dihexa is structurally optimized to penetrate the blood-brain barrier and interact with molecular targets implicated in neuroplasticity. Its unique sequence confers both stability and bioactivity, making it a promising research compound for studies involving synaptic connectivity, neuron outgrowth, and memory formation. As a small peptide, it is valued for its ability to modulate specific signaling pathways relevant to brain development and repair, supporting a wide range of applications in neuroscience and molecular biology research.
Neuroregeneration research: Dihexa has garnered significant attention in the field of neuroregeneration due to its capacity to facilitate synaptogenesis and axonal branching. By mimicking the effects of hepatocyte growth factor (HGF) and activating the c-Met receptor, it stimulates pathways that are crucial for neuron survival and regeneration. Researchers leverage this compound in in vitro and in vivo experiments to investigate mechanisms underlying neural repair after injury or in degenerative conditions, enabling the exploration of strategies to restore functional neural networks.
Cognitive enhancement studies: In the realm of cognitive neuroscience, Dihexa is frequently used as a tool to probe the molecular underpinnings of learning and memory. Its ability to enhance synaptic plasticity makes it a valuable candidate for animal models studying memory acquisition, retention, and recall. Through its action on neurotrophic signaling, it allows scientists to dissect the roles of specific peptide-mediated pathways in cognitive processes, advancing our understanding of how neural circuits adapt during learning experiences.
Neuroprotection assays: The compound's neuroprotective properties are of particular interest for research into cellular responses to oxidative stress and excitotoxicity. By modulating key growth factor pathways, Dihexa can be used to examine the prevention of neuronal cell death in various experimental models. This application supports the identification of protective mechanisms that could be harnessed to mitigate the impacts of neurotoxic insults, thereby contributing to the broader field of neurobiology.
Drug discovery and screening: Dihexa serves as an important molecular probe in high-throughput screening platforms aimed at identifying new neurotrophic agents. Its well-characterized mechanism of action provides a benchmark for evaluating the efficacy of novel compounds targeting similar pathways. Researchers utilize this peptide in comparative studies to assess the potency, selectivity, and downstream effects of candidate molecules, facilitating the development of innovative therapeutic strategies for neurological disorders.
Neural tissue engineering: The integration of Dihexa into biomaterial scaffolds or cell culture systems is being explored to promote neuronal differentiation and tissue organization. In the context of regenerative medicine, it offers a means to enhance the functional integration of transplanted cells or engineered tissues by stimulating local neurotrophic signaling. This application underscores the compound's versatility as a research tool, supporting the advancement of tissue engineering approaches for reconstructing damaged neural structures.
Behavioral neuroscience research: Dihexa is also utilized in behavioral studies to evaluate its effects on animal models exhibiting deficits in motivation, social interaction, or sensory processing. By administering the compound and monitoring behavioral outcomes, investigators gain insights into the relationship between molecular interventions and complex behaviors. Such studies contribute to a deeper understanding of the neurobiological basis of behavior and inform the development of targeted interventions for cognitive and affective dysfunctions.
3. An Open-label, Single-center, Safety and Efficacy Study of Eyelash Polygrowth Factor Serum
5. The spatiotemporal control of signalling and trafficking of the GLP-1R
If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at . We will endeavor to provide highly satisfying products and services.
Creative Peptides is a trusted CDMO partner specializing in high-quality peptide synthesis, conjugation, and manufacturing under strict cGMP compliance. With advanced technology platforms and a team of experienced scientists, we deliver tailored peptide solutions to support drug discovery, clinical development, and cosmetic innovation worldwide.
From custom peptide synthesis to complex peptide-drug conjugates, we provide flexible, end-to-end services designed to accelerate timelines and ensure regulatory excellence. Our commitment to quality, reliability, and innovation has made us a preferred partner across the pharmaceutical, biotechnology, and personal care industries.
Read More