(3,5-Diiodo-Tyr1,D-Ala2,N-Me-Phe4,glycinol5)-Enkephalin features multiple modifications that enhance aromatic density, restrict backbone movement, and modify the C-terminal chemistry. The iodinated tyrosine enhances detection and influences ring electronics. Substitutions stabilize the peptide for mechanistic studies of opioid receptor interactions. Researchers utilize it to clarify structure-activity determinants in enkephalin analogs.
4. Implications of ligand-receptor binding kinetics on GLP-1R signalling
5. Adipose tissue is a key organ for the beneficial effects of GLP-2 metabolic function
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