Dirucotide, a peptide-based therapeutic agent, is widely employed in the biomedical sector to combat the lingering effects of multiple sclerosis (MS). Its mechanism of action lies in its ability to finely regulate the immune response, effectively curtailing inflammation while concurrently safeguarding the integrity of nerve cells.
CAT No: R2049
CAS No:152074-97-0
Synonyms/Alias:Dirucotide;152074-97-0;Dirucotide [USAN:INN];Dirucotide (USAN);Dirucotide [USAN];MBP8298;26188K0CWH;DTXSID101336603;Dirucotida;Human myelin basic protein-(216-232)-peptide (major 18.5 kDa isoform-(82-98)-peptide);L-alpha-aspartyl-L-alpha-glutamyl-L-asparaginyl-L-prolyl-L-valyl-L-valyl-L-histidyl-L-phenylalanyl-L-phenylalanyl-L-lysyl-L-asparaginyl-L-isoleucyl-L-valyl-L-threonyl-L-prolyl-L-arginyl-L-threonine;L-Threonine, L-a-aspartyl-L-a-glutaMyl-L-asparaginyl-L-prolyl-L-valyl-L-valyl-L-histidyl-L- phenylal;L-Threonine, L-alpha-aspartyl-L-alpha-glutamyl-L-asparaginyl-L-prolyl-L-valyl-L-valyl-L-histidyl-L-phenylalanyl-L-phenylalanyl-L-lysyl-L-asparaginyl-L-isoleucyl-L-valyl-L-threonyl-L-prolyl-L-arginyl-;dirucotidum;MBP-8298;UNII-26188K0CWH;DIRUCOTIDE [MI];DIRUCOTIDE [INN];DIRUCOTIDE [WHO-DD];DTXCID201766829;DA-62918;D09396;ASP-GLU-ASN-PRO-VAL-VAL-HIS-PHE-PHE-LYS-ASN-ILE-VAL-THR-PRO-ARG-THR;H2N-ASP-GLU-ASN-PRO-VAL-VAL-HIS-PHE-PHE-LYS-ASN-ILE-VAL-THR-PRO-ARG-THR-OH;Human myelin basic protein-(216-232)-peptide (major 18.5 kDa isoform-(82-98)- peptide);L-THREONINE, L-.ALPHA.-ASPARTYL-L-.ALPHA.-GLUTAMYL-L-ASPARAGINYL-L-PROLYL-L-VALYL-L-VALYL-L-HISTIDYL-L-PHENYLALANYL-L-PHENYLALANYL-L-LYSYL-L-ASPARAGINYL-L-ISOLEUCYL-L-VALYL-L-THREONYL-L-PROLYL-L-ARGINYL-;L-Threonine, L-a-aspartyl-L-a-glutaMyl-L-asparaginyl-L-prolyl-L-valyl-L-valyl-L-histidyl-L- phenylalanyl-L-phenylalanyl-L-lysyl-L-asparaginyl-L-isoleucyl-L-valyl-L-thre onyl-L-prolyl-L-arginy;
Chemical Name:(4S)-5-[[(2S)-4-amino-1-[(2S)-2-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-4-amino-1-[[(2S,3S)-1-[[(2S)-1-[[(2S,3R)-1-[(2S)-2-[[(2S)-5-carbamimidamido-1-[[(1S,2R)-1-carboxy-2-hydroxypropyl]amino]-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-3-hydroxy-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-1-oxohexan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamoyl]pyrrolidin-1-yl]-1,4-dioxobutan-2-yl]amino]-4-[[(2S)-2-amino-3-carboxypropanoyl]amino]-5-oxopentanoic acid
Dirucotide is a synthetic peptide compound composed of a specific amino acid sequence derived from human myelin basic protein (MBP). As a well-characterized immunologically active peptide, Dirucotide has attracted significant attention in neuroimmunology and peptide research due to its ability to interact with major histocompatibility complex (MHC) molecules and modulate immune responses. Its defined sequence and biochemical stability make it a valuable tool for investigating antigen presentation, T-cell recognition, and the broader mechanisms of immune tolerance and autoimmunity. Researchers leverage its properties to dissect the molecular underpinnings of peptide-MHC interactions and to model disease-relevant immune processes in vitro and in vivo.
Antigen Presentation Studies: Dirucotide serves as a model peptide for studying antigen processing and presentation by MHC class II molecules. Its sequence, originating from MBP, allows researchers to examine how specific peptide fragments are recognized by antigen-presenting cells and subsequently presented to CD4+ T lymphocytes. These studies are essential for understanding the molecular determinants of T-cell epitope recognition and for mapping immunodominant regions relevant to autoimmune pathogenesis.
T-Cell Activation Assays: In immunological research, Dirucotide is frequently employed in T-cell proliferation and activation assays. By exposing immune cell cultures to this peptide, investigators can monitor T-cell receptor (TCR) specificity, cytokine release profiles, and downstream signaling events. Such experiments are instrumental in characterizing autoreactive T-cell populations and in evaluating the functional consequences of antigen-specific immune responses under controlled laboratory conditions.
Peptide-Based Immunomodulation Research: The defined structure of Dirucotide supports its use in studies aimed at modulating immune responses through peptide-based mechanisms. Researchers utilize it to investigate the induction of immune tolerance, assess the potential for antigen-specific suppression of autoreactive lymphocytes, and explore the molecular basis of immune deviation. These applications provide insights into the feasibility of peptide-based strategies for selectively altering immune function in preclinical models.
Peptide Structure-Function Analysis: Dirucotide's well-defined amino acid sequence makes it a valuable subject for structure-function relationship studies. By analyzing how specific substitutions or modifications affect its interaction with MHC molecules or TCRs, scientists can elucidate key determinants of peptide immunogenicity and stability. Such investigations contribute to the broader field of peptide engineering and facilitate the rational design of novel immunologically active peptides for research purposes.
Analytical Method Development: The synthetic nature and sequence specificity of Dirucotide make it an excellent standard or reference material in the development and validation of analytical methodologies. Techniques such as high-performance liquid chromatography (HPLC), mass spectrometry, and immunoassays benefit from the use of well-characterized peptides to calibrate instruments, assess assay sensitivity, and ensure reproducibility in peptide quantification and identification workflows. These applications enhance the reliability of analytical data in peptide research and quality control environments.
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