[Disulphonic acid]-Desmopressin carries additional sulfonic acid functionalities that greatly increase polarity and charge density. Modified side chains alter solubility, interaction with charged matrices, and conformational equilibria. Researchers employ it to study structure-analytical response relationships. Applications include impurity identification, LC-MS method development, and peptide-derivative characterization.
CAT No: R2857
Synonyms/Alias:(2R,5S,8S,11S,14S)-5-(2-amino-2-oxoethyl)-2-((S)-2-(((R)-1-((2-amino-2-oxoethyl)amino)-5-((diaminomethylene)amino)-1-oxopentan-2-yl)carbamoyl)pyrrolidine-1-carbonyl)-8-(3-amino-3-oxopropyl)-11-benzyl-14-(4-hydroxybenzyl)-4,7,10,13,16-pentaoxo-3,6,9,12,15-pentaazaoctadecane-1,18-disulfonic acid
[Disulphonic acid]-Desmopressin is a synthetic peptide analog of vasopressin, distinguished by the presence of disulphonic acid modifications that confer enhanced solubility and stability in aqueous environments. As a nonapeptide, it features a sequence specifically engineered to mimic the antidiuretic hormone's biological activity while allowing for tailored physicochemical properties. The introduction of sulfonic acid groups further augments its hydrophilicity, rendering it highly suitable for in vitro studies and peptide-based assay development. Owing to these properties, [disulphonic acid]-Desmopressin is widely recognized as a valuable tool for biochemical research focused on peptide hormone signaling, receptor-ligand interactions, and structure-activity relationship exploration in peptide therapeutics.
Peptide receptor binding studies: In receptor pharmacology, [disulphonic acid]-Desmopressin serves as a model ligand for vasopressin V2 receptor assays. Its structural similarity to endogenous vasopressin, combined with the enhanced solubility imparted by sulfonic acid groups, enables precise quantification of receptor-ligand kinetics in cell-based or membrane preparations. Researchers utilize this analog to evaluate binding affinity, receptor selectivity, and downstream signaling events, facilitating detailed characterization of G protein-coupled receptor (GPCR) mechanisms and aiding the discovery of novel modulators targeting the vasopressinergic system.
Peptide structure-activity relationship (SAR) analysis: The unique disulphonic acid modification of this peptide analog allows for systematic investigation into the effects of hydrophilic substituents on peptide stability, receptor interaction, and biological activity. By comparing its functional properties with those of unmodified desmopressin or other analogs, scientists can elucidate the structural determinants of peptide-receptor specificity and optimize sequence designs for enhanced pharmacological profiles. Such SAR studies are essential for advancing the rational design of next-generation peptide therapeutics and research probes.
Peptide synthesis optimization: [Disulphonic acid]-Desmopressin is frequently employed as a reference standard or model compound in the development and optimization of solid-phase peptide synthesis protocols. Its defined sequence and functional group modifications provide a robust system for testing coupling reagents, protecting group strategies, and purification techniques. Analytical chemists and peptide chemists leverage this peptide to assess synthesis efficiency, monitor side reactions, and validate quality control methodologies, ultimately improving the reliability and scalability of peptide production workflows.
Analytical method development: The enhanced solubility and stability characteristics of this sulfonated peptide make it an excellent candidate for validating and calibrating analytical techniques such as high-performance liquid chromatography (HPLC), mass spectrometry (MS), and capillary electrophoresis. Laboratories use it as a standard for method development, instrument calibration, and system suitability testing, particularly when analyzing highly polar or charged peptide species. Its well-characterized properties support reproducible analytical performance and facilitate accurate quantitation in complex sample matrices.
Peptide-based assay development: Researchers developing in vitro and cell-based assays for studying vasopressin signaling pathways or screening for receptor modulators often incorporate [disulphonic acid]-Desmopressin as a positive control or reference agonist. Its chemical stability and receptor selectivity enable reliable assay calibration and reproducibility, supporting a wide range of applications in pharmacological screening, signal transduction studies, and peptide hormone research. This utility extends to high-throughput screening platforms, where consistent performance is critical for data integrity and experimental comparability.
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