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Dynamin inhibitory peptide

Dynamin Inhibitory Peptide is a peptide inhibitor of the GTPase dynamin, which competitively blocks binding of dynamin to amphiphysin, thus it prevents endocytosis when administered intracellularly. It lead to GABAA receptor internalization reduce and miniature ISPC amplitude and frequency in neurons expressing GABAA receptors increase.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.
Dynamin inhibitory peptide(CAS 251634-21-6)

CAT No: R0850

CAS No:251634-21-6

Synonyms/Alias:Dynamin inhibitory peptide;251634-21-6;L-Proline, L-glutaminyl-L-valyl-L-prolyl-L-seryl-L-arginyl-L-prolyl-L-asparaginyl-L-arginyl-L-alanyl-;QVPSRPNRAP;HY-P1083;AKOS024456770;DA-63063;MS-31983;CS-0027626;G13347;

Custom Peptide Synthesis
cGMP Peptide
  • Registration of APIs
  • CMC information required for an IND
  • IND and NDA support
  • Drug master files (DMF) filing
M.F/Formula
C47H80N18O14
M.W/Mr.
1121.3
Sequence
One Letter Code:QVPSRPNRAP
Three Letter Code:H-Gln-Val-Pro-Ser-Arg-Pro-Asn-Arg-Ala-Pro-OH
Labeling Target
GTPase dynamin
Purity
>98 %
Activity
Inhibitor
Long-term Storage Conditions
Soluble in DMSO
Solubility
-20 °C
InChI
InChI=1S/C47H80N18O14/c1-23(2)35(62-36(69)25(48)14-15-33(49)67)44(77)64-19-7-12-31(64)41(74)61-29(22-66)39(72)59-27(10-5-17-56-47(53)54)43(76)63-18-6-11-30(63)40(73)60-28(21-34(50)68)38(71)58-26(9-4-16-55-46(51)52)37(70)57-24(3)42(75)65-20-8-13-32(65)45(78)79/h23-32,35,66H,4-22,48H2,1-3H3,(H2,49,67)(H2,50,68)(H,57,70)(H,58,71)(H,59,72)(H,60,73)(H,61,74)(H,62,69)(H,78,79)(H4,51,52,55)(H4,53,54,56)/t24-,25-,26-,27-,28-,29-,30-,31-,32-,35-/m0/s1
InChI Key
LHQOQXYEPUSHJL-LNIRUYPRSA-N
Isomeric SMILES
C[C@@H](C(=O)N1CCC[C@H]1C(=O)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(=O)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CO)NC(=O)[C@@H]3CCCN3C(=O)[C@H](C(C)C)NC(=O)[C@H](CCC(=O)N)N
BoilingPoint
N/A
Melting Point
N/A

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