Dynamin Inhibitory Peptide is a peptide inhibitor of the GTPase dynamin, which competitively blocks binding of dynamin to amphiphysin, thus it prevents endocytosis when administered intracellularly. It lead to GABAA receptor internalization reduce and miniature ISPC amplitude and frequency in neurons expressing GABAA receptors increase.
CAT No: R0850
CAS No: 251634-21-6
Synonyms/Alias: Dynamin inhibitory peptide;251634-21-6;L-Proline, L-glutaminyl-L-valyl-L-prolyl-L-seryl-L-arginyl-L-prolyl-L-asparaginyl-L-arginyl-L-alanyl-;QVPSRPNRAP;HY-P1083;AKOS024456770;DA-63063;MS-31983;CS-0027626;G13347;
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M.F/Formula | C47H80N18O14 |
M.W/Mr. | 1121.3 |
Sequence | One Letter Code:QVPSRPNRAP Three Letter Code:H-Gln-Val-Pro-Ser-Arg-Pro-Asn-Arg-Ala-Pro-OH |
Labeling Target | GTPase dynamin |
Purity | >98 % |
Activity | Inhibitor |
Long-term Storage Conditions | Soluble in DMSO |
Solubility | -20 °C |
InChI | InChI=1S/C47H80N18O14/c1-23(2)35(62-36(69)25(48)14-15-33(49)67)44(77)64-19-7-12-31(64)41(74)61-29(22-66)39(72)59-27(10-5-17-56-47(53)54)43(76)63-18-6-11-30(63)40(73)60-28(21-34(50)68)38(71)58-26(9-4-16-55-46(51)52)37(70)57-24(3)42(75)65-20-8-13-32(65)45(78)79/h23-32,35,66H,4-22,48H2,1-3H3,(H2,49,67)(H2,50,68)(H,57,70)(H,58,71)(H,59,72)(H,60,73)(H,61,74)(H,62,69)(H,78,79)(H4,51,52,55)(H4,53,54,56)/t24-,25-,26-,27-,28-,29-,30-,31-,32-,35-/m0/s1 |
InChI Key | LHQOQXYEPUSHJL-LNIRUYPRSA-N |
Isomeric SMILES | C[C@@H](C(=O)N1CCC[C@H]1C(=O)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(=O)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CO)NC(=O)[C@@H]3CCCN3C(=O)[C@H](C(C)C)NC(=O)[C@H](CCC(=O)N)N |
BoilingPoint | N/A |
Melting Point | N/A |
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