Ebiratide Triacetate is a multi-acetylated peptide in which terminal and side-chain amino functions are selectively capped. The acetyl groups reduce overall charge and can favor defined conformational states. Researchers evaluate its behavior in receptor-binding, membrane-interaction, and stability assays. Applications include analog-optimization efforts, structural-biophysics work, and acetylation-effect studies.
CAT No: R2875
CAS No:115994-46-2
Synonyms/Alias:Ebiratide triacetate; UNII-S4QA804W04; S4QA804W04; 115994-46-2; L-Phenylalaninamide, (2S)-2-amino-4-(methylsulfonyl)butanoyl-L-alpha-glutamyl-L-histidyl-L-phenylalanyl-D-lysyl-Nalpha-(8-aminooctyl)-, triacetate; EX-A6648
Ebiratide triacetate is a synthetic peptide derivative recognized for its unique amino acid sequence and acetylated structure, which contribute to its stability and functional properties in biochemical research. As a member of the peptide compound category, it is designed to mimic or modulate specific protein interactions, making it highly relevant for studies focused on peptide-protein binding, cellular signaling, and receptor engagement. Its triacetate modification enhances resistance to enzymatic degradation, allowing for more controlled experimental applications and reliable data generation. The compound's ability to engage in targeted biochemical interactions positions it as a valuable tool for researchers investigating peptide-mediated processes in vitro and in cell-based systems.
Peptide-receptor interaction studies: Ebiratide triacetate is frequently utilized in research aiming to elucidate the mechanisms of peptide-receptor binding and downstream signaling events. Its defined sequence and acetylated form enable precise modeling of ligand-receptor dynamics, facilitating the characterization of binding affinities, receptor specificity, and activation or inhibition profiles. Scientists employ this peptide in assays such as surface plasmon resonance, isothermal titration calorimetry, and cell-based receptor activation models to dissect the molecular determinants of peptide recognition and signal transduction.
Peptide structure-function analysis: The triacetate form of this compound is particularly advantageous in studies dissecting the relationship between peptide conformation and biological activity. Researchers use it to explore how sequence modifications and acetylation influence secondary structure, stability, and interaction with target biomolecules. Circular dichroism spectroscopy, nuclear magnetic resonance, and computational modeling are among the techniques employed to assess structural features and correlate them with functional outcomes, supporting rational peptide design and optimization.
Protease resistance and stability assessment: Due to its acetylated termini, the peptide serves as a model substrate for evaluating the impact of chemical modifications on proteolytic resistance. In vitro protease assays leverage its enhanced stability to compare degradation rates with unmodified analogs, providing insights into strategies for improving peptide half-life in research applications. Such studies are critical for developing peptides with improved pharmacokinetic profiles for use in complex biological matrices or extended experimental protocols.
Cell signaling pathway investigation: The compound's ability to engage specific receptors or cellular targets makes it a valuable probe for dissecting intracellular signaling cascades. Researchers incorporate it into cell-based assays to monitor activation or inhibition of pathways such as MAPK, PI3K/Akt, or other relevant cascades, using readouts like phosphorylation status, reporter gene expression, or downstream effector activation. These studies contribute to a deeper understanding of peptide-mediated regulation in physiological and experimental contexts.
Peptide synthesis and analytical method development: Ebiratide triacetate is also used as a reference material or standard in the optimization of peptide synthesis protocols and the validation of analytical techniques. Its defined structure and acetylation pattern make it suitable for calibrating chromatographic systems, mass spectrometry platforms, and peptide purification workflows. Laboratories rely on such standards to ensure reproducibility, accuracy, and sensitivity in peptide quantification and characterization, supporting high-quality research outcomes across diverse applications.
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