Ecnoglutide features a designed peptide backbone used for evaluating receptor-ligand interactions and structural stability under diverse conditions. Hydrophobic and charged residues contribute to its defined conformational states. Researchers analyze solvent effects and folding equilibria to understand sequence performance. Applications span peptide engineering, signaling studies, and structural optimization.
CAT No: R2452
CAS No:2459531-73-6
Synonyms/Alias:Ecnoglutide;Ecnoglutide [INN];UNII-KM6YM7L8LH;KM6YM7L8LH;2459531-73-6;GLXC-26838;DA-63110;His-Val-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr--Leu-Glu-Glu-Gln-Ala-Ala-Arg-Glu-Phe-Ile-(17-((S)-5-Hydroxy-4-(18-hydroxy-18-oxooctadecanamido)-5-oxopentanamido)-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanoyl)Lys-Trp-Leu-Val-Arg-Gly-Arg-Gly;
Ecnoglutide is a synthetic peptide compound that functions as a glucagon-like peptide-1 (GLP-1) receptor agonist, structurally designed to mimic the activity of endogenous incretin hormones. As a member of the peptide therapeutics class, it exhibits enhanced resistance to enzymatic degradation and prolonged activity compared to native GLP-1. The molecular features of ecnoglutide make it highly relevant for biochemical studies investigating peptide-receptor interactions, metabolic regulation, and the broader physiological roles of incretin mimetics. Its unique sequence modifications and receptor selectivity have positioned it as a valuable tool for research focused on peptide signaling pathways and metabolic modulation.
Peptide-receptor interaction studies: Ecnoglutide is extensively utilized in research aimed at elucidating the molecular dynamics between GLP-1 analogs and their cognate receptors. Its high affinity and selectivity for the GLP-1 receptor enable detailed investigations into ligand binding, receptor activation, and downstream signaling events. Researchers leverage its stability and receptor specificity to dissect the structural determinants of peptide-receptor engagement, facilitating the design of next-generation peptide agonists with improved pharmacological profiles.
Metabolic pathway analysis: The compound serves as an effective probe for studying the regulation of glucose homeostasis and energy metabolism at the cellular and systemic levels. By acting as a GLP-1 receptor agonist, ecnoglutide allows for controlled activation of signaling cascades involved in insulin secretion, glucagon suppression, and appetite modulation. Its application in cell-based assays, organoid models, and metabolic flux studies provides critical insights into the mechanisms governing nutrient sensing and hormonal cross-talk.
Peptide engineering and optimization: Ecnoglutide is frequently employed as a reference molecule or template in the development and optimization of novel peptide-based agonists. Its sequence modifications and enhanced stability inform structure-activity relationship (SAR) studies, guiding the rational design of peptides with tailored receptor selectivity and functional properties. By comparing analogs and derivatives to ecnoglutide, researchers can systematically evaluate the impact of specific amino acid substitutions and backbone modifications on biological activity.
Analytical method development: The compound is instrumental in the validation and calibration of analytical techniques designed to quantify peptide drugs and their metabolites in complex biological matrices. Its well-characterized physicochemical properties make it a suitable standard for liquid chromatography, mass spectrometry, and immunoassay platforms. Analytical laboratories utilize ecnoglutide to optimize sample preparation protocols, assess assay sensitivity, and ensure the accuracy of peptide quantification in pharmacokinetic and metabolic studies.
In vitro pharmacology assays: Ecnoglutide is widely adopted in in vitro systems to characterize the functional consequences of GLP-1 receptor activation. Its robust receptor agonism enables reproducible assessment of downstream effects such as cyclic AMP accumulation, β-cell signaling, and gene expression changes. These assays are critical for screening the efficacy of peptide analogs, elucidating receptor pharmacology, and modeling the cellular responses to incretin mimetics in a controlled laboratory environment.
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