Edratide, an ingenious peptide-based pharmaceutical, fosters a beacon of hope for those grappling with rheumatoid arthritis. By gripping the reins of pro-inflammatory cytokines and quelling the immune response, this therapeutic masterpiece orchestrates an impregnable fortress of immune suppression.
CAT No: R2059
CAS No:433922-67-9
Synonyms/Alias:Edratide;433922-67-9;Edratide [INN];hCDR1 peptide;UNII-38PLP07BKC;38PLP07BKC;Edratide [USAN:INN:BAN];TV-4710;EDRATIDE [USAN];DTXSID60195840;Glycyl-L-tyrosyl-L-tyrosyl-L-tryptophyl-L-seryl-L-tryptophyl-L-isoleucyl-L-arginyl-L-glutaminyl-L-prolyl-L-prolylglycyl-L-lysylglycyl-L-glutamyl-L-glutamyl-L-tryptophyl-L-isoleucylglycine;L-Glycyl-L-tyrosyl- L-tyrosyl- L-tryptophyl-L-seryl-L-tryptophyl-L-isoleucyl-L-arginyl-L-glutaminyl-L-prolyl-L-prolyl-L-glycyl-L-lysyl-L-glycyl-L-glutamyl-L-glutamyl-L-tryptophyl-L-isoleucyl-L-glycine;edratidum;DTXCID00118331;DB15272;DA-52816;Q27256802;L-GLYCYL-L-TYROSYL-L-TYROSYL-L-TRYPTOPHYL-L-SERYL-L-TRYPTOPHYL-L-ISOLEUCYL-L-ARGINYL-L-GLUTAMINYL-L-PROLYL-L-PROLYL-L-GLYCYL-L-LYSYL-L-GLYCYL-L-GLUTAMYL-L-GLUTAMYL-L-TRYPTOPHYL-L-ISOLEUCYL-L-GLYCINE;
Chemical Name:(4S)-4-[[2-[[(2S)-6-amino-2-[[2-[[(2S)-1-[(2S)-1-[(2S)-5-amino-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-aminoacetyl)amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-methylpentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-oxopentanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonyl]amino]acetyl]amino]hexanoyl]amino]acetyl]amino]-5-[[(2S)-4-carboxy-1-[[(2S)-1-[[(2S,3S)-1-(carboxymethylamino)-3-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1-oxobutan-2-yl]amino]-5-oxopentanoic acid
Edratide is a synthetic peptide that has garnered significant attention in immunological and autoimmune research due to its unique sequence and functional properties. As a peptide derived from a region of the human Ro60 autoantigen, it serves as a valuable molecular tool for scientists investigating the mechanisms of immune tolerance, autoantigen recognition, and peptide-based modulation of immune responses. Its biochemical structure enables precise interaction with immune system components, making it relevant for studies aiming to dissect the molecular underpinnings of autoimmunity. The ability to synthesize Edratide with high fidelity further enhances its utility in controlled experimental settings, supporting a wide range of investigative and translational research initiatives in immunology and peptide science.
Immunological research: Edratide is widely utilized in immunological studies focused on T-cell epitope mapping and antigen-specific immune response characterization. Researchers employ the peptide to probe how immune cells recognize and respond to specific autoantigenic determinants, enabling detailed analysis of T-cell receptor engagement, antigen processing, and presentation pathways. Such studies are critical for elucidating the molecular mechanisms underlying the breakdown of self-tolerance and the initiation of autoimmune processes.
Autoimmunity modeling: In experimental models of autoimmune disease, Edratide serves as a defined antigen for inducing or modulating immune responses. By introducing this peptide into ex vivo or in vivo systems, investigators can monitor antigen-specific cellular and humoral immune activities, providing insights into the development and progression of autoimmunity. The controlled use of Edratide facilitates the assessment of immune regulatory pathways, offering a platform to evaluate factors that influence disease susceptibility and resilience.
Peptide-based immunomodulation: The unique sequence and epitope characteristics of Edratide make it a valuable candidate for studies exploring peptide-mediated modulation of immune responses. Researchers leverage its properties to investigate the potential for inducing antigen-specific tolerance or altering T-cell reactivity, which is essential for understanding how peptides can be engineered to redirect immune responses. This line of inquiry supports the rational design of novel immunomodulatory strategies for research applications.
Biochemical assay development: Edratide is employed in the development and optimization of biochemical assays aimed at detecting autoantibody or T-cell responses to Ro60 epitopes. Its defined structure and immunogenic potential allow for the standardization of assay conditions, facilitating reproducible measurement of immune reactivity in experimental samples. Such assays are instrumental in advancing basic and translational research on autoantigen recognition and immune profiling.
Peptide synthesis and structural studies: The synthetic accessibility of Edratide enables its use as a model peptide for investigating peptide synthesis methodologies and structure-activity relationships. Scientists utilize it to refine solid-phase peptide synthesis protocols, assess peptide folding and stability, and explore structure-function correlations relevant to antigenicity. These studies contribute to the broader understanding of peptide chemistry and inform the development of optimized peptides for diverse research purposes.
3. SERS spectrum of the peptide thymosin‐β4 obtained with Ag nanorod substrate
4. Implications of ligand-receptor binding kinetics on GLP-1R signalling
If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at . We will endeavor to provide highly satisfying products and services.
Creative Peptides is a trusted CDMO partner specializing in high-quality peptide synthesis, conjugation, and manufacturing under strict cGMP compliance. With advanced technology platforms and a team of experienced scientists, we deliver tailored peptide solutions to support drug discovery, clinical development, and cosmetic innovation worldwide.
From custom peptide synthesis to complex peptide-drug conjugates, we provide flexible, end-to-end services designed to accelerate timelines and ensure regulatory excellence. Our commitment to quality, reliability, and innovation has made us a preferred partner across the pharmaceutical, biotechnology, and personal care industries.
Read More