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Exherin

ADH-1, an N-cadherin antagonist, inhibits N-cadherin mediated cell adhesion.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.
Exherin(CAS 229971-81-7)

CAT No: HB00096

CAS No:229971-81-7

Synonyms/Alias:Exherin;229971-81-7;ADH-1;ADH 1;Exherin free base;Cys-his-ala-val-cys;B058ME29VU;NSC-729477;DTXSID4044036;229971-81-7 (free base);L-Cysteinamide, N-acetyl-L-cysteinyl-L-histidyl-l-alanyl-L-valyl-, cyclic (1-5)-disulfide;NSC 729477;(4R,7S,10S,13S,16R)-13-((1H-imidazol-5-yl)methyl)-16-acetamido-7-isopropyl-10-methyl-6,9,12,15-tetraoxo-1,2-dithia-5,8,11,14-tetraazacycloheptadecane-4-carboxamide;(4R,7S,10S,13S,16R)-16-acetamido-13-(1H-imidazol-5-ylmethyl)-10-methyl-6,9,12,15-tetraoxo-7-propan-2-yl-1,2-dithia-5,8,11,14-tetrazacycloheptadecane-4-carboxamide;UNII-B058ME29VU;ADH-1 pepide;CHEMBL3818130;SCHEMBL13857500;DTXCID401012044;EX-A3549;ADH-10001;AKOS030526741;CS-3450;DA-63339;HY-13541;D83667;Q4651113;BRD-K81795818-019-01-4;C518575000;

Custom Peptide Synthesis
cGMP Peptide
  • Registration of APIs
  • CMC information required for an IND
  • IND and NDA support
  • Drug master files (DMF) filing
M.F/Formula
C22H34N8O6S2
M.W/Mr.
570.7
Sequence
One Letter Code:CHAVC
Three Letter Code:Ac-Cys(1)-His-Ala-Val-Cys(1)-NH2
Activity
Antagonist
Biological Activity
Exherin, also known as ADH-1, is a small, cyclic pentapeptide vascular-targeting agent with potential antineoplastic and antiangiogenic activities. ADH-1 selectively and competitively binds to and blocks N-cadherin, which may result in disruption of tumor vasculature, inhibition of tumor cell growth, and the induction of tumor cell and endothelial cell apoptosis.
Long-term Storage Conditions
Soluble to 2.2 mg/mL in DMSO
Shipping Condition
Room temperature in continental US; may vary elsewhere.
InChI
InChI=1S/C22H34N8O6S2/c1-10(2)17-22(36)29-15(18(23)32)7-37-38-8-16(27-12(4)31)21(35)28-14(5-13-6-24-9-25-13)20(34)26-11(3)19(33)30-17/h6,9-11,14-17H,5,7-8H2,1-4H3,(H2,23,32)(H,24,25)(H,26,34)(H,27,31)(H,28,35)(H,29,36)(H,30,33)/t11-,14-,15-,16-,17-/m0/s1
InChI Key
FQVLRGLGWNWPSS-BXBUPLCLSA-N

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