Exherin

Tetracosactide is a synthetic peptide, which corresponds to the first 24 amino acids of the naturally occurring hormone ACTH (adrenocorticotropic hormone). It stimulates the adrenal cortex to produce corticosteroids, mineralocorticoids, and, to a lesser extent, androgens.

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CAT#HB00096
Chemical Structure
ExplanationADH-1, an N-cadherin antagonist, inhibits N-cadherin mediated cell adhesion.
M.F/FormulaC22H34N8O6S2
M.W/Mr.570.69
ActivityAntagonist
Biological ActivityExherin, also known as ADH-1, is a small, cyclic pentapeptide vascular-targeting agent with potential antineoplastic and antiangiogenic activities. ADH-1 selectively and competitively binds to and blocks N-cadherin, which may result in disruption of tumor vasculature, inhibition of tumor cell growth, and the induction of tumor cell and endothelial cell apoptosis.
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