Eyeliss is a cosmetic-research peptide blend associated with studies on microcirculation, extracellular-matrix interactions, and fluid homeostasis in skin models. Component peptides feature charged and lipophilic residues that modulate diffusion and binding to matrix proteins. Researchers evaluate its effects on capillary-mimetic systems and dermal cell cultures. Applications span cosmetic peptide screening, formulation optimization, and skin-biology research.
CAT No: R2722
CAS No:24292-52-2
Synonyms/Alias:Hesperidin methylchalcone;24292-52-2;Hesperidin methyl chalcone;EYELISS;hesperidine methylchalcone;EINECS 246-128-2;UNII-4T2GVA922X;4T2GVA922X;(E)-1-(4-((6-O-(6-Deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-2-hydroxy-6-methoxyphenyl)-3-(3-hydroxy-4-methoxyphenyl)-2-propen-1-one;DTXSID90885262;(E)-3-(3-hydroxy-4-methoxyphenyl)-1-[2-hydroxy-6-methoxy-4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxyphenyl]prop-2-en-1-one;HESPERIDIN METHYL CHALCONE [VANDF];HESPERIDIN METHYL CHALCONE [WHO-DD];2-Propen-1-one, 1-(4-((6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-2-hydroxy-6-methoxyphenyl)-3-(3-hydroxy-4-methoxyphenyl)-, (2E)-;2-Propen-1-one, 1-[4-[[6-O-(6-deoxy-.alpha.-L-mannopyranosyl)-.beta.-D-glucopyranosyl]oxy]-2-hydroxy-6-methoxyphenyl]-3-(3-hydroxy-4-methoxyphenyl)-, (2E)-;Chalcone, 2',3,4'-trihydroxy-4,6'-dimethoxy-, 4'-(6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside);MFCD00010438;(E)-1-(4-((6-O-(6-DEOXY-.ALPHA.-L-MANNOPYRANOSYL)-.BETA.-D-GLUCOPYRANOSYL)OXY)-2-HYDROXY-6-METHOXYPHENYL)-3-(3-HYDROXY-4-METHOXYPHENYL)-2-PROPEN-1-ONE;(E)-3-(3-Hydroxy-4-methoxyphenyl)-1-(2-hydroxy-6-methoxy-4-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-((((2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)methyl)tetrahydro-2H-pyran-2-yl)oxy)phenyl)prop-2-en-1-one;2-PROPEN-1-ONE,1-(4-((6-O-(6-DEOXY-ALFA-L-MANNOPYRANOSYL)-.BETA.-D-GLUCOPYRANOSYL)OXY)-2-HYDROXY-6-METHOXYPHENYL)-3-(3-HYDROXY-4-METHOXYPHENYL)-, (E)-;hesperidin methyl chalone;(E)-1-[4-[[6-O-(6-Deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl]oxy]-2-hydroxy-6-methoxyphenyl]-3-(3-hydroxy-4-methoxyphenyl)-2-propen-1-one;(E)-3-(3-hydroxy-4-methoxyphenyl)-1-(2-hydroxy-6-methoxy-4-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(((2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl)oxymethyl)oxan-2-yl)oxyphenyl)prop-2-en-1-one;SCHEMBL3452314;CHEMBL5435071;FDHNLHLOJLLXDH-JIYHLSBYSA-N;DTXCID401024653;STK801860;AKOS015895097;OH34622;HESPERIDIN METHYL CHALCONE [INCI]
Eyeliss is a specialized peptide-based cosmetic ingredient formulated to address common concerns associated with the delicate skin around the eyes. Designed through advanced peptide synthesis, Eyeliss combines a blend of active compounds that work synergistically to support the natural function of the periorbital area. Its unique composition targets underlying mechanisms that contribute to visible signs of fatigue and stress, such as puffiness and under-eye bags. By enhancing microcirculation and reinforcing capillary integrity, Eyeliss offers a science-driven approach for cosmetic formulations aimed at rejuvenating and revitalizing the eye contour. The ingredient is widely recognized for its integration into high-performance eye care products, where it serves as a key component for delivering targeted benefits without the use of invasive procedures.
Cosmetic Formulations: Eyeliss is extensively utilized in the development of premium eye creams, serums, and gels designed to minimize the appearance of puffiness and under-eye bags. Cosmetic chemists incorporate this peptide complex into formulations to provide a gentle yet effective solution for consumers seeking visible improvements in the eye area. Its compatibility with various emulsion systems and stability under typical cosmetic manufacturing conditions make it a preferred choice for formulators aiming to create innovative, results-oriented skincare products.
Anti-Fatigue Solutions: The peptide blend in Eyeliss is valued for its ability to combat visible signs of tiredness, making it a popular ingredient in anti-fatigue skincare lines. By supporting lymphatic drainage and microvascular function, it helps reduce the accumulation of fluids and toxins that can lead to puffiness and dullness around the eyes. Manufacturers leverage its efficacy in products marketed to individuals experiencing stress, lack of sleep, or prolonged screen time, providing a non-invasive option for refreshing the eye area.
Dermal Research: Eyeliss is frequently employed as a model compound in dermal and cosmetic research aimed at understanding the molecular mechanisms of periorbital skin aging. Researchers utilize it to investigate how peptide complexes influence capillary permeability, extracellular matrix remodeling, and cellular communication in the delicate tissues surrounding the eyes. The insights gained from such studies inform the development of next-generation cosmetic actives and contribute to the broader field of skin biology.
Personal Care Product Innovation: The versatility of Eyeliss enables its application in a wide range of personal care products beyond traditional eye creams. It is incorporated into sheet masks, overnight treatments, and even color cosmetics such as concealers and foundations that offer skincare benefits. Product developers value its ability to enhance the functional profile of formulations, delivering both immediate cosmetic effects and long-term skin support for consumers seeking comprehensive eye area care.
In vitro Testing and Efficacy Evaluation: Eyeliss serves as a reference ingredient in in vitro testing protocols designed to evaluate the efficacy of new cosmetic actives targeting periorbital concerns. Laboratories use it as a benchmark for assessing improvements in microcirculation, capillary strength, and fluid homeostasis in cultured skin models. Its well-documented mechanism of action and established performance metrics provide a valuable standard for comparison, facilitating the screening and optimization of novel ingredients in the competitive field of cosmetic science.
2. Myotropic activity of allatostatins in tenebrionid beetles
3. An Open-label, Single-center, Safety and Efficacy Study of Eyelash Polygrowth Factor Serum
5. SERS spectrum of the peptide thymosin‐β4 obtained with Ag nanorod substrate
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