FGL Peptide corresponds to a neural cell adhesion molecule-derived sequence used to study neurite outgrowth and cell-cell interaction in vitro. The motif balances hydrophobic and charged residues to support protein-binding surfaces. Researchers probe its influence on adhesion-related signaling and structural assembly. Applications include cell-adhesion modeling, peptide-biomaterial design, and motif-function analysis.
CAT No: R2587
CAS No:499993-62-3
Synonyms/Alias:FGL peptide;HY-P3281;DA-53184;CS-0655069;499993-62-3;
FGL peptide is a synthetic peptide derived from the neural cell adhesion molecule (NCAM), specifically encompassing the fibronectin type III (FNIII) module. As a functional peptide sequence, FGL is recognized for its capacity to mimic the biological activity of NCAM, thereby modulating cell-cell interactions, neurite outgrowth, and synaptic plasticity in neural tissue. Its unique sequence and structural properties have positioned it as a valuable molecular tool in neurobiological research, particularly for probing mechanisms of neural development, plasticity, and signaling. Due to these characteristics, FGL peptide serves as a critical reagent for studies seeking to unravel the complex interplay between cell adhesion molecules and neuronal function.
Neuroscience research: FGL peptide is widely utilized in experimental models to study mechanisms underlying neuronal differentiation, synaptic connectivity, and plasticity. By emulating the functional domain of NCAM, it facilitates investigations into how cell adhesion influences neural circuit formation and remodeling. Researchers employ this peptide to dissect the signaling pathways that govern neurite extension, synapse stabilization, and the dynamic regulation of neural networks, providing crucial insights into both developmental and adult neurobiology.
Cell signaling pathway analysis: In vitro and in vivo studies often incorporate FGL peptide to elucidate the downstream signaling cascades initiated by NCAM engagement. The peptide's ability to activate key intracellular pathways, such as those involving fibroblast growth factor receptor (FGFR) and mitogen-activated protein kinase (MAPK), makes it a powerful tool for mapping molecular events that mediate cell survival, proliferation, and differentiation. Such analyses are instrumental in identifying potential molecular targets for modulating neural function and resilience.
Peptide-functional studies: As a model system for peptide-mimetic research, FGL peptide is employed to explore the structure-activity relationships of bioactive peptides derived from cell adhesion molecules. It enables systematic modification and testing of sequence variants to determine critical residues responsible for biological activity. This approach supports the rational design of novel peptide analogs with tailored properties for research applications, advancing the understanding of molecular recognition and specificity in peptide-mediated interactions.
Synaptic plasticity assays: Experimental protocols assessing synaptic function frequently incorporate FGL peptide to modulate plasticity-related processes in neuronal cultures or brain slice preparations. Its capacity to influence long-term potentiation (LTP) and long-term depression (LTD) provides a mechanistic handle for studying the molecular basis of learning and memory. By manipulating synaptic efficacy via peptide treatment, researchers can delineate the contributions of cell adhesion signaling to cognitive processes and adaptive neural responses.
Neuroprotection and cellular resilience studies: FGL peptide is also investigated for its effects on neuronal survival under conditions of cellular stress or injury in preclinical models. By engaging NCAM-related pathways, it has been shown to enhance cell viability and support recovery in various experimental paradigms. These studies contribute to a deeper understanding of endogenous neuroprotective mechanisms and the role of cell adhesion molecules in maintaining neural integrity during adverse conditions.
1. Cationic cell-penetrating peptides are potent furin inhibitors
4. Emerging applications of nanotechnology for diagnosis and therapy of disease: a review
5. Cell-based adhesion assays for isolation of snake venom’s integrin antagonists
If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at . We will endeavor to provide highly satisfying products and services.
Creative Peptides is a trusted CDMO partner specializing in high-quality peptide synthesis, conjugation, and manufacturing under strict cGMP compliance. With advanced technology platforms and a team of experienced scientists, we deliver tailored peptide solutions to support drug discovery, clinical development, and cosmetic innovation worldwide.
From custom peptide synthesis to complex peptide-drug conjugates, we provide flexible, end-to-end services designed to accelerate timelines and ensure regulatory excellence. Our commitment to quality, reliability, and innovation has made us a preferred partner across the pharmaceutical, biotechnology, and personal care industries.
Read More