FR 179642 is an impurity of Micafungin, a lipopeptide compound that acts as an antifungal agent with activity against Aspergillus and Candida species.
CAT No: Z10-101-162
CAS No:168110-44-9
Synonyms/Alias:1-[(4R,5R)-4,5-Dihydroxy-L-ornithine]-4-[(4S)-4-hydroxy-4-[4-hydroxy-3-(sulfooxy)phenyl]-L-threonine]pneumocandin A0; 1-[(4R,5R)-4,5-Dihydroxy-L-ornithine]-4-[(S)-4-hydroxy-4-[4-hydroxy-3-(sulfooxy)phenyl]-L-threonine]pneumocandin A0; CMICA; FR 133303
FR 179642 is a unique carbohydrate compound that has gained significant attention in scientific research due to its distinctive structural features and versatile bioactivity. As a synthetic iminosugar, FR 179642 is characterized by its ability to mimic monosaccharides while possessing an altered ring structure, which enables it to interact with various carbohydrate-processing enzymes. Researchers value this compound for its stability, solubility in aqueous solutions, and its compatibility with a range of biochemical assays. The molecular design of FR 179642 allows it to function as a potent modulator of glycosidase activity, making it a valuable tool for probing glycan-related biological processes. Its well-defined structure also facilitates the exploration of enzyme-substrate specificity, providing insights into the mechanisms underlying carbohydrate metabolism and recognition.
Glycosidase Inhibition: FR 179642 serves as a powerful inhibitor of several glycosidases, enzymes responsible for the hydrolysis of glycosidic bonds in carbohydrates. By competitively binding to the active sites of these enzymes, this iminosugar can effectively block the breakdown of oligosaccharides and polysaccharides. This property is particularly useful in research focused on understanding the regulation of glycan processing and in the development of enzyme-targeted strategies for modulating cellular glycosylation patterns. The ability of FR 179642 to inhibit specific glycosidases enables detailed studies on the role of these enzymes in health and disease, as well as the screening of novel inhibitors for therapeutic research.
Glycobiology Research: The unique structure of FR 179642 makes it an indispensable tool in glycobiology, where it is used to dissect complex carbohydrate-mediated interactions within biological systems. By selectively modulating glycosidase activity, researchers can investigate the biosynthesis, remodeling, and degradation of glycoconjugates such as glycoproteins and glycolipids. This compound aids in elucidating the functional significance of glycan structures on cellular surfaces, contributing to a deeper understanding of cell-cell communication, immune recognition, and pathogen-host interactions. The versatility of FR 179642 in experimental design allows for the precise manipulation of glycan profiles in model organisms and cultured cells.
Enzyme Mechanism Studies: FR 179642 is frequently employed in mechanistic studies aimed at unraveling the catalytic processes of carbohydrate-active enzymes. Its structural mimicry of natural sugars, coupled with its resistance to enzymatic cleavage, provides a platform for kinetic analyses and structural investigations using techniques such as X-ray crystallography and NMR spectroscopy. By serving as a substrate analog or transition state mimic, FR 179642 enables the characterization of enzyme active sites, identification of key catalytic residues, and exploration of conformational dynamics during substrate turnover. These insights are essential for the rational design of enzyme inhibitors and the engineering of enzymes with altered specificity.
Drug Discovery and Screening: The inhibitory properties of FR 179642 make it a valuable compound in high-throughput screening assays for the identification of new glycosidase inhibitors. Its use as a reference compound or positive control enhances the reliability of screening platforms aimed at discovering molecules with potential pharmacological relevance. In addition, FR 179642 can be employed in structure-activity relationship studies to optimize lead compounds for increased potency and selectivity. The availability of this iminosugar supports the development of novel chemical entities targeting glycan-processing enzymes, thereby expanding the repertoire of tools for drug discovery research.
Analytical Method Development: Researchers utilize FR 179642 in the development and validation of analytical methods for detecting and quantifying glycosidase activity. Its defined inhibitory profile allows for the calibration of enzyme assays, ensuring accuracy and reproducibility in experimental measurements. The compound can also be incorporated into protocols for the assessment of enzyme kinetics, inhibitor screening, and substrate specificity determination. By serving as a benchmark in enzymatic studies, FR 179642 contributes to the standardization of analytical workflows in carbohydrate chemistry and enzymology laboratories. Through these diverse applications, FR 179642 continues to facilitate advances in glycoscience, enzymology, and chemical biology, supporting innovative research across multiple disciplines.
3. Myotropic activity of allatostatins in tenebrionid beetles
4. Emu oil in combination with other active ingredients for treating skin imperfections
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