fStAx-35R TFA is a stapled peptide analogue engineered to stabilize α-helical structure and modulate protein-protein interaction interfaces. Hydrocarbon stapling and arginine-rich surfaces tune cell-permeation and target affinity in vitro. Researchers assess helix content, thermal stability, and binding thermodynamics. Applications include PPI-inhibitor model systems, conformational control studies, and stapled-peptide optimization.
CAT No: R2851
fStAx-35R TFA is a synthetic peptide compound designed for advanced research applications in the field of peptide science. As a member of the StAx peptide family, it incorporates specific sequence modifications that confer unique biochemical properties, making it a valuable tool for investigating protein-protein interactions, signal transduction pathways, and the structural dynamics of peptide assemblies. The trifluoroacetate (TFA) salt form enhances its solubility and handling characteristics, which is particularly advantageous for laboratory use. Owing to its well-defined structure and functional versatility, fStAx-35R TFA is widely recognized among researchers seeking to elucidate the molecular mechanisms underlying cellular processes and to develop novel peptide-based technologies.
Peptide-Protein Interaction Studies: In the context of molecular biology and biochemistry, fStAx-35R TFA serves as a powerful probe for dissecting the interactions between peptides and their target proteins. Its defined sequence allows researchers to map binding sites, assess affinity, and characterize the specificity of peptide-mediated recognition events. These studies are instrumental in unraveling the regulatory networks that govern cellular function and in identifying potential modulators of protein activity for further investigation.
Structure-Activity Relationship (SAR) Analysis: The compound is frequently utilized in SAR studies aimed at correlating specific sequence motifs or amino acid substitutions with biological activity. By employing fStAx-35R TFA in systematic analog screening, scientists can pinpoint critical residues that influence binding affinity, stability, or functional output. Insights gained from such analyses guide the rational design of next-generation peptides with optimized properties for research or biotechnological applications.
Peptide Synthesis Method Development: Owing to its synthetic origin and tailored modifications, fStAx-35R TFA is employed as a reference standard or model substrate in the development and optimization of peptide synthesis protocols. Researchers use it to evaluate coupling efficiencies, test new protecting group strategies, and refine purification methodologies. These efforts contribute to the advancement of peptide chemistry by enhancing yield, purity, and reproducibility in laboratory-scale and industrial peptide production.
Biochemical Assays and Functional Screening: The unique characteristics of fStAx-35R TFA make it suitable for use in a range of in vitro biochemical assays. It is incorporated into experimental platforms to assess enzymatic activity, probe signaling cascades, or evaluate the efficacy of small molecule inhibitors. Its robust performance in these contexts supports high-throughput screening efforts and facilitates the discovery of new modulators of peptide-mediated processes.
Biophysical Characterization: Researchers leverage fStAx-35R TFA for detailed biophysical studies, including circular dichroism, fluorescence spectroscopy, and nuclear magnetic resonance (NMR) analysis. Its stable conformation and well-defined sequence enable precise measurement of secondary structure, folding dynamics, and intermolecular interactions. These investigations provide fundamental insights into peptide behavior under various conditions and inform the design of peptides with tailored structural or functional attributes.
2. Cationic cell-penetrating peptides are potent furin inhibitors
4. Urinary Metabolites Associated with Blood Pressure on a Low-or High-Sodium Die
5. Emerging applications of nanotechnology for diagnosis and therapy of disease: a review
If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at . We will endeavor to provide highly satisfying products and services.
Creative Peptides is a trusted CDMO partner specializing in high-quality peptide synthesis, conjugation, and manufacturing under strict cGMP compliance. With advanced technology platforms and a team of experienced scientists, we deliver tailored peptide solutions to support drug discovery, clinical development, and cosmetic innovation worldwide.
From custom peptide synthesis to complex peptide-drug conjugates, we provide flexible, end-to-end services designed to accelerate timelines and ensure regulatory excellence. Our commitment to quality, reliability, and innovation has made us a preferred partner across the pharmaceutical, biotechnology, and personal care industries.
Read More