Gastrin I (1-14), human is 1-14 fragment of human gastrin I peptide. Gastrin I is an endogenous, gastrointestinal peptide hormone. Gastrin is the major hormonal regulator of gastric acid secretion.
Gastrin I (1-14), human is a synthetic peptide fragment corresponding to the N-terminal 14 amino acids of the full-length human gastrin hormone. As a biologically active peptide, it plays a pivotal role in gastrointestinal physiology by stimulating gastric acid secretion and regulating digestive processes. The truncated form, encompassing residues 1 through 14, retains significant biological activity and is widely utilized in research to elucidate the structure-function relationships within the gastrin peptide family. Its defined sequence and conserved motifs make it a valuable molecular tool for probing receptor interactions, signal transduction pathways, and peptide processing mechanisms in both basic and applied biochemical studies.
Receptor binding studies: The 1-14 fragment of human gastrin is frequently employed to investigate its interaction with cholecystokinin B/gastrin (CCK-B) receptors. Researchers utilize this peptide to characterize binding affinities, receptor specificity, and downstream signaling events, thereby advancing the understanding of gastrin-mediated cellular responses. The defined sequence enables precise mapping of ligand-receptor contacts, which is essential for dissecting the molecular determinants of receptor activation and selectivity within the CCK/gastrin receptor family.
Peptide structure-function analysis: As a representative bioactive fragment, the peptide serves as a model substrate for exploring the relationship between primary sequence, secondary structure, and biological activity. By comparing the functional properties of the 1-14 peptide with longer or modified gastrin analogs, scientists can delineate critical regions necessary for activity, receptor recognition, and stability. These comparative studies inform the rational design of novel peptide analogs with tailored properties for research or industrial applications.
Enzymatic processing research: Gastrin I (1-14) is a valuable substrate for investigating the enzymatic cleavage and post-translational modification pathways that regulate peptide hormone maturation. Biochemists use this fragment to study the specificity and activity of peptidases, carboxypeptidases, and amidating enzymes involved in the biosynthesis of active gastrin forms. Such research provides insights into the mechanisms controlling hormone activation and degradation, which are fundamental to understanding gastrointestinal endocrine regulation.
Peptide-receptor signaling pathway elucidation: The peptide is instrumental in dissecting the intracellular signaling cascades initiated by gastrin receptor engagement. Through in vitro and cell-based assays, researchers can monitor second messenger production, kinase activation, and gene expression changes in response to peptide stimulation. These studies contribute to a comprehensive understanding of how gastrin influences cellular physiology, growth, and differentiation in target tissues.
Analytical assay development: The defined sequence and robust activity of the 1-14 fragment make it an ideal standard or calibrator in immunoassays, receptor binding assays, and chromatographic analyses. Laboratories utilize this peptide to establish assay sensitivity, validate detection methods, and quantify endogenous or exogenous gastrin-related peptides in experimental samples. Its use as a reference material ensures reproducibility and accuracy in biochemical investigations of peptide hormones and their analogs.
If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at . We will endeavor to provide highly satisfying products and services.
Creative Peptides is a trusted CDMO partner specializing in high-quality peptide synthesis, conjugation, and manufacturing under strict cGMP compliance. With advanced technology platforms and a team of experienced scientists, we deliver tailored peptide solutions to support drug discovery, clinical development, and cosmetic innovation worldwide.
From custom peptide synthesis to complex peptide-drug conjugates, we provide flexible, end-to-end services designed to accelerate timelines and ensure regulatory excellence. Our commitment to quality, reliability, and innovation has made us a preferred partner across the pharmaceutical, biotechnology, and personal care industries.
Read More