[Gln8]-C517 (LH-RH), chicken is an avian hypothalamic peptide, which stimulates release of gonadotropins from anterior pituitary, thus regulating reproductive functions.
![[Gln8]-C517 (LH-RH), chicken(CAS 47922-48-5)](https://img.creative-peptides.com/structure/47922-48-52d.png)
CAT No: R1121
CAS No:47922-48-5
Synonyms/Alias:47922-48-5;[Gln8]-C517 (LH-RH), chicken;LHRH, Gln(8)-;PYR-HIS-TRP-SER-TYR-GLY-LEU-GLN-PRO-GLY-NH2;[Gln8]GnRH;(Pglu-his-trp-ser-tyr-gly-leu-gln-pro-glynh2);8-Glutamine-LHRH;GNRH, Chicken I;8-Gln-LHRH;Gnrh, gln(8)-;LHRH-I;pGlu-His-Trp-Ser-Tyr-Gly-Leu-Gln-Pro-Gly-NH2;LHRH, Glutamine(8)-;chicken GnRH;Lhrh(chicken);GTPL1169;DTXSID10197354;[GLN8]-C517, CHICKEN;HY-P1905;LHRH (chicken) trifluoroacetate salt;DA-54903;MS-32016;CS-0097995;G12358;Glycinamide, 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosylglycyl-L-leucyl-L-glutaminyl-L-prolyl-;
[Gln8]-C517 (LH-RH), chicken is a synthetic peptide analog derived from the luteinizing hormone-releasing hormone (LH-RH) sequence, specifically modified at the eighth amino acid position with glutamine. As a member of the gonadotropin-releasing hormone (GnRH) family, this compound serves as an important tool for investigating the structure-activity relationships and receptor interactions of avian neuropeptides. Its unique sequence modification allows researchers to dissect the functional consequences of amino acid substitutions within the LH-RH framework, making it particularly relevant for comparative endocrinology and peptide signaling studies in avian species. The availability of such analogs supports advancements in understanding hormonal regulation, receptor specificity, and peptide engineering.
Peptide structure-activity relationship studies: In peptide research, [Gln8]-C517 (LH-RH), chicken is utilized to systematically examine how specific amino acid substitutions affect biological activity and receptor binding affinity. By substituting glutamine at position eight, scientists can assess the impact of side-chain alterations on the potency and selectivity of LH-RH analogs. These investigations contribute to the broader knowledge of peptide-receptor interactions, guiding the rational design of novel analogs with tailored functional properties.
Receptor binding assays: The compound is widely employed in binding assays to characterize the specificity and affinity of avian LH-RH receptors. Using radiolabeled or fluorescently tagged versions of this analog, researchers can quantify receptor-ligand interactions in tissue extracts or recombinant systems. Such studies are essential for elucidating the molecular determinants of ligand recognition and for mapping the distribution of GnRH receptor subtypes in avian neuroendocrine tissues.
Comparative endocrinology research: [Gln8]-C517 (LH-RH), chicken offers valuable insights into evolutionary differences in hormone signaling between avian and mammalian species. By comparing the biological responses elicited by this analog in various animal models, researchers can investigate species-specific adaptations in GnRH signaling pathways. These comparative studies deepen the understanding of hormonal regulation and its evolutionary diversification across vertebrates.
Peptide synthesis and analytical method development: The peptide serves as a reference standard and substrate in the optimization of solid-phase peptide synthesis protocols. Its defined sequence and functional modifications make it suitable for validating synthetic methods, assessing peptide purity, and refining analytical techniques such as high-performance liquid chromatography (HPLC) and mass spectrometry. The compound's utility in method development ensures the reliability and reproducibility of peptide production workflows.
Functional studies in neuroendocrinology: Researchers utilize this LH-RH analog to probe the physiological roles of GnRH peptides in the avian hypothalamic-pituitary-gonadal (HPG) axis. By administering the analog in controlled experimental settings, scientists can monitor downstream effects on hormone secretion, gene expression, and cellular signaling pathways. Such functional assays provide mechanistic insights into neuroendocrine regulation and facilitate the identification of key modulators within the HPG axis in birds.
If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at . We will endeavor to provide highly satisfying products and services.
Creative Peptides is a trusted CDMO partner specializing in high-quality peptide synthesis, conjugation, and manufacturing under strict cGMP compliance. With advanced technology platforms and a team of experienced scientists, we deliver tailored peptide solutions to support drug discovery, clinical development, and cosmetic innovation worldwide.
From custom peptide synthesis to complex peptide-drug conjugates, we provide flexible, end-to-end services designed to accelerate timelines and ensure regulatory excellence. Our commitment to quality, reliability, and innovation has made us a preferred partner across the pharmaceutical, biotechnology, and personal care industries.
Read More