Glycoyl-Thr-Octreotide carries a glycoacylated threonine appended to the octreotide core, introducing additional polarity and potential carbohydrate-mediated recognition. The modification influences solubility and local conformational preferences. Researchers use it to study glyco-peptide interactions and transport behavior. Applications include peptide-glycan conjugate design, structural-biochemistry work, and SAR investigations.
CAT No: Z10-101-215
Synonyms/Alias:(2R)-2-((4R,7S,10S,13R,16S,19R)-13-((1H-indol-3-yl)methyl)-19-(2-amino-3-phenylpropanamido)-10-(4-aminobutyl)-16-benzyl-4-((1,3-dihydroxybutan-2-yl)carbamoyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-7-yl)propyl 2-hydroxyacetate; (2R,3R)-3-((4R,7S,10S,13R,16S,19R)-13-((1H-Indol-3-yl)methyl)-19-((R)-2-amino-3-phenylpropanamido)-10-(4-aminobutyl)-16-benzyl-7-(1-hydroxyethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosane-4-carboxamido)-4-hydroxybutan-2-yl 2-hydroxyacetate
Glycoyl-Thr-Octreotide is a specialized carbohydrate-peptide conjugate that merges the bioactivity of octreotide, a somatostatin analog, with the unique properties conferred by glycosylation. This molecular modification enhances the compound's solubility, stability, and bioavailability, making it a valuable tool for scientific research. By incorporating a glycosylated threonine residue, Glycoyl-Thr-Octreotide exhibits altered pharmacokinetics and receptor-binding characteristics compared to its non-glycosylated counterpart. Researchers are increasingly interested in this compound for its potential to modulate peptide-receptor interactions and its improved resistance to enzymatic degradation, which can be critical in various experimental settings. The tailored structure of Glycoyl-Thr-Octreotide enables precise investigation into peptide transport, receptor targeting, and the impact of glycosylation on peptide function, supporting advanced studies in molecular biology, biochemistry, and glycobiology.
Receptor Binding Studies: Glycoyl-Thr-Octreotide is extensively utilized in receptor binding assays to evaluate the influence of glycosylation on somatostatin receptor affinity and selectivity. By comparing the binding profiles of glycosylated versus non-glycosylated analogs, researchers can elucidate the structural determinants that govern receptor interaction. This information is critical for designing next-generation peptide ligands with optimized receptor targeting features, providing a foundation for advancements in receptor biology and signaling pathway research.
Peptide Stability Investigation: In the context of peptide stability, the glycosylated structure of this compound offers a robust model for examining resistance to proteolytic degradation. Scientists employ Glycoyl-Thr-Octreotide in enzymatic assays to monitor its metabolic fate and to determine how glycosylation shields peptide backbones from protease activity. These studies inform the development of more durable peptide-based tools for laboratory and industrial applications, where stability is paramount for efficacy and reproducibility.
Cellular Uptake and Transport: The enhanced hydrophilicity and altered molecular recognition properties of Glycoyl-Thr-Octreotide make it an excellent candidate for probing cellular uptake mechanisms. By tracking its internalization in various cell lines, researchers gain insights into the role of glycosylation in modulating peptide transport across cellular membranes. These findings contribute to a broader understanding of peptide delivery systems and intracellular trafficking, which are essential for the development of targeted research tools in cell biology.
Structure-Activity Relationship Analysis: Glycoyl-Thr-Octreotide serves as a model compound in structure-activity relationship (SAR) investigations, allowing scientists to dissect how specific glycosyl modifications influence biological function. Through comparative studies with structurally related analogs, researchers can map the effects of carbohydrate moieties on potency, selectivity, and downstream signaling. These SAR analyses are instrumental in guiding the rational design of novel peptides with tailored bioactivities for experimental and discovery-oriented purposes.
Glycobiology Method Development: In the field of glycobiology, this glycosylated peptide is a valuable standard for method development and validation. Laboratories employ Glycoyl-Thr-Octreotide in chromatographic and spectrometric techniques to optimize detection, quantification, and characterization protocols for glycopeptides. Its defined structure and unique glycan-peptide linkage make it an ideal reference for troubleshooting analytical workflows and benchmarking new technologies, ultimately advancing the capabilities of carbohydrate and peptide research.
3. Implications of ligand-receptor binding kinetics on GLP-1R signalling
4. Peptides as Active Ingredients: A Challenge for Cosmeceutical Industry
5. Emerging applications of nanotechnology for diagnosis and therapy of disease: a review
If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at . We will endeavor to provide highly satisfying products and services.
Creative Peptides is a trusted CDMO partner specializing in high-quality peptide synthesis, conjugation, and manufacturing under strict cGMP compliance. With advanced technology platforms and a team of experienced scientists, we deliver tailored peptide solutions to support drug discovery, clinical development, and cosmetic innovation worldwide.
From custom peptide synthesis to complex peptide-drug conjugates, we provide flexible, end-to-end services designed to accelerate timelines and ensure regulatory excellence. Our commitment to quality, reliability, and innovation has made us a preferred partner across the pharmaceutical, biotechnology, and personal care industries.
Read More