Gonadorelin Acetate Hydrate is another name for gonadotropin-releasing hormone (GnRH). It is a synthetic decapeptide prepared using solid phase peptide synthesis.
CAT No: R1944
CAS No:52699-48-6
Synonyms/Alias:L-pyroglutamyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-glycyl-L-leucyl-L-arginyl-L-prolyl-glycinamide; acetic acid; hydrate
Chemical Name:acetic acid;(2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[(2S)-2-[(2-amino-2-oxoethyl)carbamoyl]pyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide;hydrate
Gonadorelin Acetate Hydrate is a synthetic decapeptide that precisely mimics the structure and activity of natural gonadotropin-releasing hormone (GnRH). As a key regulator of the hypothalamic-pituitary-gonadal (HPG) axis, this compound plays a central role in controlling the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the anterior pituitary gland. Its biochemical significance extends to fundamental studies in endocrinology, reproductive biology, and neuroendocrine signaling, making it an indispensable tool for researchers investigating hormonal regulation and peptide-receptor interactions.
Endocrine signaling research: Gonadorelin analogs such as this hydrate form are widely employed to dissect the mechanisms underlying GnRH receptor activation and downstream signaling cascades. By providing a consistent and bioactive ligand, the compound enables researchers to study receptor binding kinetics, signal transduction events, and desensitization processes within pituitary and hypothalamic cell models. These insights are crucial for unraveling the temporal dynamics of hormone release and for understanding feedback regulation within the HPG axis.
Reproductive physiology studies: The peptide's ability to stimulate the release of gonadotropins makes it highly valuable for probing the physiological regulation of reproductive hormones in animal models and in vitro systems. Investigators utilize it to induce synchronized LH and FSH surges, facilitating exploration of ovarian and testicular function, gametogenesis, and the molecular basis of reproductive cycles. Such studies advance knowledge of fertility regulation and the intricate hormonal interplay governing reproductive health.
Peptide-receptor interaction assays: In receptor pharmacology, Gonadorelin Acetate Hydrate serves as a reference agonist for characterizing GnRH receptor subtypes and their ligand-binding properties. Its well-defined sequence and activity profile support competitive binding studies, receptor activation assays, and the evaluation of novel modulators or antagonists. These applications are instrumental in mapping receptor specificity, affinity, and signaling diversity across different tissues and species.
Peptide synthesis and analytical validation: As a model decapeptide, Gonadorelin Acetate Hydrate is frequently used in peptide synthesis laboratories for method development, purification protocol optimization, and analytical validation. Its defined structure and established chromatographic behavior make it an ideal standard for calibrating peptide separation techniques, mass spectrometry analysis, and quality control procedures in research and manufacturing environments.
Cell culture and in vitro modeling: The compound is routinely incorporated into cell culture systems to modulate gonadotropin release and to establish physiologically relevant models of pituitary function. By introducing precise concentrations of the peptide, researchers can simulate hormonal pulses, assess cellular responsiveness, and investigate the transcriptional and secretory outcomes of GnRH stimulation. These in vitro models are essential for elucidating hormone-driven gene expression patterns and for screening potential modulators of reproductive endocrinology.
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