Gonadorelin is a trophic peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is synthesized and released from GnRH neurons within the hypothalamus. The peptide belongs to gonadotropin-releasing hormone family. It constitutes the initial step in the hypothalamic–pituitary–gonadal axis.
CAT No: 10-101-166
CAS No:33515-09-2(net)
Synonyms/Alias:GONADORELIN;Luliberin;Gonadorelina;Gonadorelinum;33515-09-2;Fertagyl;LH-Releasing factor;Luteostimulin;Relefact;Lutal;GnRH-I;Gonadotropin-releasing factor;Mammalian GnRH;Synthetic LRF;Dirigestran Spofa;Synthetic Gn-RH;Mammalian LH-RH;Synthetic LH-RF;Synthetic LH-RH;Porchine LH-RH;Hypocrine;Human LH-RH;Ovine LH-RH;LH-RH (swine);Synthetic gonadoliberin;Gonadoreline;Synthetic LH-FSH-RH;Gonadoliberin I;5-oxo-PHWSYGLRPGNH2;Synthetic LH-RH/FSH-RH;LH-Releasing factor (pig);Porcine LH-releasing factor;Synthetic LH-releasing factor;CHEBI:5520;Human gonadoliberin-i;p-Glu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2;UNII-9O7312W37G;Gonadorelin decapeptide;Synthetic decapeptide FSH/LH-RH;HOE 471;EINECS 251-553-1;Gonadorelinum [INN-Latin];Gonadorelina [INN-Spanish];AY 24031;9034-40-6;LH-RH;Dirigestran;Glycinamide, 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosylglycyl-L-leucyl-L-arginyl-L-prolyl-;Gonadorelinum (INN-Latin);Gonadorelina (INN-Spanish);5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosylglycyl-L-leucyl-L-arginyl-L-prolylglycinamide;AY-24031;Gn-RH;Luforan;Lutrefact;Nialutin;Relisorm l;LFRH;LHFSHRH;pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2;LH-RF;Gonadorelin [INN:BAN];71447-49-9;Fertelin, OvaCyst;Fertagyl (TN);EINECS 232-895-0;Gonadorelin (INN);AY 24034;CHEMBL1007;GONADORELIN (MART.);SCHEMBL143114;[125I]-GnRH I;GTPL3786;DTXSID20873490;H01CA01;V04CM01;5-oxoPro-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2 (human or pig);BDBM50422274;AKOS015895122;AKOS030213247;9O7312W37G;CCG-270650;HS-2014;[125I]GnRH I (human, mouse, rat);Luteinizing hormone-areleasing factor (swine);D08027;pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-GlyNH2;GONADORELIN (GONADORELIN DECAPEPTIDE (GNRH));pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH(2);BRD-K96874295-015-01-0;GONADOTROPIN-RELEASING HORMONE (GNRH) ANALOGUE;Q20817116;5-OXOPRO-HIS-TRP-SER-TYR-GLY-LEU-ARG-PRO-GLY-NH2;LUTEINISING HORMONE-RELEASING FACTOR (LNRH) ANALOGUE;251-553-1;5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl- glycyl-L-leucyl-L-arginyl-L-prolyl-glycinamide;L-Pyroglutamyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosylglycyl-L-leucyl-L-arginyl-L-prolylglycinamide;
Gonadorelin is a synthetic decapeptide that functions as a gonadotropin-releasing hormone (GnRH) analog, structurally identical to the endogenous hypothalamic hormone responsible for regulating the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the anterior pituitary. As a key regulator within the hypothalamic-pituitary-gonadal (HPG) axis, Gonadorelin has become an invaluable tool in biochemical, endocrinological, and physiological research. Its precise sequence and well-characterized mechanism of action make it a standard compound for probing reproductive hormone signaling, elucidating neuroendocrine feedback loops, and supporting the development of peptide-based analytical methods.
Reproductive endocrinology research: Gonadorelin is widely utilized in studies investigating the regulation of reproductive hormones. By mimicking the action of endogenous GnRH, it enables researchers to stimulate pituitary secretion of LH and FSH in controlled experimental settings, facilitating the analysis of feedback mechanisms, hormone pulse dynamics, and downstream effects within the HPG axis. Such studies are essential for understanding the molecular basis of reproductive physiology and for modeling disorders of gonadotropin regulation in both animal and in vitro systems.
Peptide receptor characterization: The compound serves as a reference ligand in the characterization of GnRH receptor subtypes and their signaling pathways. By providing a defined and consistent stimulus, it allows for the assessment of receptor binding kinetics, signal transduction efficiency, and receptor desensitization or downregulation phenomena. These applications are fundamental in receptor pharmacology, enabling the identification of agonists, antagonists, and modulators with potential research or industrial relevance.
Peptide synthesis and analytical method development: Owing to its well-defined sequence and established bioactivity, Gonadorelin is frequently employed as a model peptide in the optimization of solid-phase peptide synthesis protocols and in the validation of chromatographic or mass spectrometric analytical methods. Its use as a standard or reference material supports the development of robust, reproducible techniques for peptide purification, quantification, and structural analysis, which are critical for advancing both basic and applied peptide science.
Cell signaling studies: In cellular and molecular biology, Gonadorelin is used to probe GnRH-mediated intracellular signaling cascades. By triggering receptor-mediated events such as calcium mobilization, protein phosphorylation, and gene expression changes, it enables detailed investigations into the molecular mechanisms underlying GnRH action. These studies contribute to a deeper understanding of signal integration, cellular responsiveness, and the impact of modulatory factors on neuroendocrine pathways.
Comparative physiology: The compound is instrumental in comparative studies exploring the conservation and divergence of GnRH signaling across species. Its application in non-human models allows researchers to examine evolutionary adaptations in neuroendocrine control, reproductive strategies, and hormonal feedback loops. Such comparative work not only enhances knowledge of vertebrate endocrinology but also informs translational research in related fields.
Through its multifaceted roles in experimental endocrinology, receptor biology, peptide chemistry, and comparative physiology, Gonadorelin continues to provide researchers with a reliable and versatile tool for advancing the scientific understanding of hormone regulation and peptide function. Its consistent performance and well-documented properties underpin its widespread adoption in laboratories focused on unraveling the complexities of neuroendocrine signaling and reproductive biology.
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