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Gonadorelin

Gonadorelin is a trophic peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is synthesized and released from GnRH neurons within the hypothalamus. The peptide belongs to gonadotropin-releasing hormone family. It constitutes the initial step in the hypothalamic–pituitary–gonadal axis.

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CAT No: 10-101-166

CAS No: 33515-09-2(net)

Synonyms/Alias: GONADORELIN;Luliberin;Gonadorelina;Gonadorelinum;33515-09-2;Fertagyl;LH-Releasing factor;Luteostimulin;Relefact;Lutal;GnRH-I;Gonadotropin-releasing factor;Mammalian GnRH;Synthetic LRF;Dirigestran Spofa;Synthetic Gn-RH;Mammalian LH-RH;Synthetic LH-RF;Synthetic LH-RH;Porchine LH-RH;Hypocrine;Human LH-RH;Ovine LH-RH;LH-RH (swine);Synthetic gonadoliberin;Gonadoreline;Synthetic LH-FSH-RH;Gonadoliberin I;5-oxo-PHWSYGLRPGNH2;Synthetic LH-RH/FSH-RH;LH-Releasing factor (pig);Porcine LH-releasing factor;Synthetic LH-releasing factor;CHEBI:5520;Human gonadoliberin-i;p-Glu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2;UNII-9O7312W37G;Gonadorelin decapeptide;Synthetic decapeptide FSH/LH-RH;HOE 471;EINECS 251-553-1;Gonadorelinum [INN-Latin];Gonadorelina [INN-Spanish];AY 24031;9034-40-6;LH-RH;Dirigestran;Glycinamide, 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosylglycyl-L-leucyl-L-arginyl-L-prolyl-;Gonadorelinum (INN-Latin);Gonadorelina (INN-Spanish);5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosylglycyl-L-leucyl-L-arginyl-L-prolylglycinamide;AY-24031;Gn-RH;Luforan;Lutrefact;Nialutin;Relisorm l;LFRH;LHFSHRH;pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2;LH-RF;Gonadorelin [INN:BAN];71447-49-9;Fertelin, OvaCyst;Fertagyl (TN);EINECS 232-895-0;Gonadorelin (INN);AY 24034;CHEMBL1007;GONADORELIN (MART.);SCHEMBL143114;[125I]-GnRH I;GTPL3786;DTXSID20873490;H01CA01;V04CM01;5-oxoPro-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2 (human or pig);BDBM50422274;AKOS015895122;AKOS030213247;9O7312W37G;CCG-270650;HS-2014;[125I]GnRH I (human, mouse, rat);Luteinizing hormone-areleasing factor (swine);D08027;pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-GlyNH2;GONADORELIN (GONADORELIN DECAPEPTIDE (GNRH));pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH(2);BRD-K96874295-015-01-0;GONADOTROPIN-RELEASING HORMONE (GNRH) ANALOGUE;Q20817116;5-OXOPRO-HIS-TRP-SER-TYR-GLY-LEU-ARG-PRO-GLY-NH2;LUTEINISING HORMONE-RELEASING FACTOR (LNRH) ANALOGUE;251-553-1;5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl- glycyl-L-leucyl-L-arginyl-L-prolyl-glycinamide;L-Pyroglutamyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosylglycyl-L-leucyl-L-arginyl-L-prolylglycinamide;

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Specification Technical Data Publications Customer reviews and Q&A
M.F/FormulaC55H75N17O13
M.W/Mr.1182.3
SequenceOne Letter Code:XHWSYGLRPG
Three Letter Code:H-Pyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2
ApplicationGonadorelin is also known as LHRH. After a transient increase, continuous administration results in downregulation of LH and FSH levels followed by a suppression of ovarian and testicular steroid biosynthesis.
AppearanceSolid powder
ActivityAgonist
Biological ActivityGonadorelin is a synthetic decapeptide with a structure identical with the natural Gonadotrophin. Releasing Hormone (Gn-RH) in mammalian species.
TargetGonadotropin-releasing hormone receptor
Length10
Shipping ConditionRoom temperature in continental US; may vary elsewhere.
InChIInChI=1S/C55H75N17O13/c1-29(2)19-38(49(80)67-37(9-5-17-60-55(57)58)54(85)72-18-6-10-43(72)53(84)62-25-44(56)75)66-46(77)26-63-47(78)39(20-30-11-13-33(74)14-12-30)68-52(83)42(27-73)71-50(81)40(21-31-23-61-35-8-4-3-7-34(31)35)69-51(82)41(22-32-24-59-28-64-32)70-48(79)36-15-16-45(76)65-36/h3-4,7-8,11-14,23-24,28-29,36-43,61,73-74H,5-6,9-10,15-22,25-27H2,1-2H3,(H2,56,75)(H,59,64)(H,62,84)(H,63,78)(H,65,76)(H,66,77)(H,67,80)(H,68,83)(H,69,82)(H,70,79)(H,71,81)(H4,57,58,60)/t36-,37-,38-,39-,40-,41-,42-,43-/m0/s1
InChI KeyXLXSAKCOAKORKW-AQJXLSMYSA-N

1. Constitutive and inflammation-dependent antimicrobial peptides produced by epithelium are differentially processed and inactivated by the commensal Finegoldia magna and the pathogen Streptococcus pyogenes

2. Immune responses to homocitrulline-and citrulline-containing peptides in rheumatoid arthritis

3. TMEM16F and dynamins control expansive plasma membrane reservoirs

4. An Isolated TCR αβ Restricted by HLA-A* 02: 01/CT37 Peptide Redirecting CD8+ T Cells to Kill and Secrete IFN-γ in Response to Lung Adenocarcinoma Cell Lines

5. Tachykinin-related peptides modulate immune-gene expression in the mealworm beetle Tenebrio molitor L

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