Gozetotide presents a tailored peptide ligand designed to recognize defined receptor epitopes with high selectivity. Side-chain diversity balances hydrophobic contacts and charge-based interactions, enabling controlled binding studies. Researchers examine its conformational ensemble in solution and membrane mimetics. Applications include receptor-mapping research, peptide-based probe development, and structural optimization work.
CAT No: R2706
CAS No:1366302-52-4
Synonyms/Alias:PSMA-11;1366302-52-4;Psma-hbed-CC;9AG41L3AOQ;GOZETOTIDE;(3S,7S)-22-(3-(((2-((5-(2-Carboxyethyl)-2-hydroxybenzyl)(carboxymethyl)amino)ethyl)(carboxymethyl)amino)methyl)-4-hydroxyphenyl)-5,13,20-trioxo-4,6,12,19-tetraazadocosane-1,3,7-tricarboxylic acid;UNII-9AG41L3AOQ;CHEMBL3578202;(2S)-2-[[(1S)-1-carboxy-5-[6-[3-[3-[[2-[[5-(2-carboxyethyl)-2-hydroxyphenyl]methyl-(carboxymethyl)amino]ethyl-(carboxymethyl)amino]methyl]-4-hydroxyphenyl]propanoylamino]hexanoylamino]pentyl]carbamoylamino]pentanedioic acid;4,6,12,19-Tetraazadocosane-1,3,7-tricarboxylic acid, 22-[3-[[[2-[[[5-(2-carboxyethyl)-2-hydroxyphenyl]methyl](carboxymethyl)amin;4,6,12,19-Tetraazadocosane-1,3,7-tricarboxylic acid, 22-[3-[[[2-[[[5-(2-carboxyethyl)-2-hydroxyphenyl]methyl](carboxymethyl)amino]ethyl](carboxymethyl)amino]methyl]-4-hydroxyphenyl]-5,13,20-trioxo-, (3S,7S)-;MFCD29767877;PSMA11;PSMA11?;SCHEMBL18059388;EX-A5539;BDBM50089451;AKOS040749246;AT42199;DA-57200;MS-31767;HY-125399;CS-0091105;Q27895124;PSMA-11; 4,6,12,19-Tetraazadocosane-1,3,7-tricarboxylic acid, 22-[3-[[[2-[[[5-(2-carboxyethyl)-2-hydroxyphenyl]methyl](carboxymethyl)amino]ethyl](carboxymethyl)amino]methyl]-4-hydroxyphenyl]-5,13,20-trioxo-, (3S,7S)-; (3S,7S)-22-[3-[[[2-[[[5-(2-Carboxyethyl)-2-hyd;
Gozetotide is a synthetic peptide compound that has garnered significant attention in the field of molecular imaging and targeted research applications. As a peptide analog designed to bind specifically to certain cell surface receptors, it serves as a valuable tool for scientists investigating receptor-mediated processes and the underlying mechanisms of cellular communication. Its structure enables high-affinity interactions with specific biomolecular targets, making it particularly useful in studies that require precise molecular recognition. The unique characteristics of gozetotide, such as its stability and receptor selectivity, contribute to its growing utility in advanced biochemical and biomedical research settings.
Receptor binding studies: Gozetotide is widely utilized in receptor binding assays to characterize the affinity and specificity of peptide-receptor interactions. Researchers employ it to map the distribution and density of target receptors on various cell types, which is essential for elucidating receptor function in physiological and pathological contexts. By enabling quantitative and qualitative assessment of receptor-ligand dynamics, the peptide supports the development of new hypotheses regarding cell signaling pathways and receptor-mediated cellular responses.
Molecular imaging research: The compound's ability to selectively bind to particular cell surface markers makes it an ideal candidate for molecular imaging probe development. When conjugated with imaging agents such as radiolabels or fluorescent tags, gozetotide facilitates the visualization of receptor-expressing cells and tissues in preclinical models. This application is critical for advancing the understanding of receptor distribution, tissue targeting, and in vivo biodistribution, thereby supporting the optimization of imaging protocols and probe design in molecular imaging studies.
Peptide-based drug discovery: In the context of drug discovery, gozetotide serves as a model ligand for screening and validating novel compounds that interact with specific peptide receptors. Its defined binding properties allow researchers to assess the efficacy and selectivity of new therapeutic candidates in vitro. By acting as a reference molecule in competitive binding assays, it helps streamline the identification and optimization of lead compounds targeting receptor-mediated pathways.
Cellular signaling investigations: The compound is frequently employed in studies aimed at dissecting the molecular mechanisms of cellular signaling. By modulating receptor activity through specific binding, gozetotide enables researchers to probe downstream signaling cascades and evaluate the functional consequences of receptor engagement. These investigations are instrumental in uncovering the complex interplay between extracellular signals and intracellular responses, contributing to a deeper understanding of cell biology and signal transduction networks.
Analytical method development: Gozetotide's well-characterized structure and receptor selectivity make it a valuable standard in the development and validation of analytical techniques for peptide quantification and detection. Laboratories utilize it to optimize assay conditions, calibrate instrumentation, and establish quality control parameters in peptide analysis workflows. Its application in analytical method development ensures the reliability and reproducibility of experimental data in peptide research and related biochemical investigations.
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