Guangxitoxin 1E

Guangxitoxin-1E is a specific inhibitor of the Kv current of β-cells, can enhance the glucose-dependent intracellular calcium elevations and increases the glucose-dependent insulin secretion. It is considered as a useful tool for the investigation of type 2 diabetes.

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CAT#	R0935
CAS	1233152-82-3
Background	Guangxitoxin-1E (GxTX-1E) is a strong inhibitor of the Kv current of β-cells. GxTX-1E enhances the glucose-dependent intracellular calcium elevations and increases the glucose-dependent insulin secretion. It is suspected that Guangxitoxin-1E blocks of Kv2.1 channel and may be a useful tool for the investigation of type 2 diabetes. >> Read More
M.F/Formula	C178H248N44O45S7
M.W/Mr.	3948.61
Sequence	EGECGGFWWKCGSGKPACCPKYVCSPKWGLCNFPMP(Modifications: Disulfide bridge: 4-19,11-24,18-31)
Labeling Target	Kv2.1 / Kv2.2 channel
Appearance	White lyophilized solid
Purity	>98%
Activity	Inhibitor

CAT#	Product Name	M.W	Molecular Formula	Inquiry
R0861	AmmTX3	3822.47	C158H262N50O48S6	Inquiry
R0978	Agitoxin 2	4090.87	C169H278N54O48S8	Inquiry
R0995	Margatoxin	4178.96	C178H286N52O50S7	Inquiry
R1045	BeKm 1	4091.65	C174H261N51O52S6	Inquiry

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Source#	Synthetic
Storage	-20°C
Solubility	Soluble in water
Long-term Storage Conditions	-20 °C
InChI	InChI=1S/C178H248N44O45S7/c1-95(2)70-118-159(247)214-131(165(253)208-124(77-139(184)226)163(251)209-125(73-99-34-11-8-12-35-99)175(263)219-65-28-49-137(219)171(259)203-117(59-69-268-6)174(262)222-68-31-50-138(222)178(266)267)92-272-271-91-130-167(255)216-133-94-274-270-90-128(213-158(246)115(56-58-147(235)236)195-142(229)83-189-150(238)108(183)55-57-146(233)234)153(241)190-81-140(227)188-82-141(228)198-119(71-98-32-9-7-10-33-98)160(248)206-123(76-103-80-187-111-41-18-15-38-107(103)111)162(250)207-122(75-102-79-186-110-40-17-14-37-106(102)110)161(249)200-112(42-19-23-60-179)157(245)212-129(154(242)193-86-145(232)199-126(87-223)152(240)192-84-143(230)196-116(45-22-26-63-182)173(261)218-64-27-46-134(218)168(256)194-97(5)149(237)211-130)89-269-273-93-132(215-172(260)148(96(3)4)217-164(252)120(72-100-51-53-104(225)54-52-100)204-155(243)113(43-20-24-61-180)201-170(258)136-48-30-67-221(136)177(133)265)166(254)210-127(88-224)176(264)220-66-29-47-135(220)169(257)202-114(44-21-25-62-181)156(244)205-121(151(239)191-85-144(231)197-118)74-101-78-185-109-39-16-13-36-105(101)109/h7-18,32-41,51-54,78-80,95-97,108,112-138,148,185-187,223-225H,19-31,42-50,55-77,81-94,179-183H2,1-6H3,(H2,184,226)(H,188,227)(H,189,238)(H,190,241)(H,191,239)(H,192,240)(H,193,242)(H,194,256)(H,195,229)(H,196,230)(H,197,231)(H,198,228)(H,199,232)(H,200,249)(H,201,258)(H,202,257)(H,203,259)(H,204,243)(H,205,244)(H,206,248)(H,207,250)(H,208,253)(H,209,251)(H,210,254)(H,211,237)(H,212,245)(H,213,246)(H,214,247)(H,215,260)(H,216,255)(H,217,252)(H,233,234)(H,235,236)(H,266,267)
InChI Key	SZVUKNYCMKWHNH-UHFFFAOYSA-N
References	In addition to being more potent than hanatoxin or stromatoxin, this peptide, Guangxitoxin-1E (GxTX-1E) had higher specificity for Kv2 channels, inhibiting Kv4.3 channels with an 8-fold lower potency and without significant effect on Kv1 or Kv3 family channels. The high selectivity of GxTX-1E for Kv2 makes it an attractive tool for studying the function of Kv2 channels in various types of neurons. Kv2 Channel Regulation of Action Potential Repolarization and Firing Patterns in Superior Cervical Ganglion Neurons and Hippocampal CA1 Pyramidal Neurons