Hexacosanedioic acid is an alpha,omega-dicarboxylic acid that is hexacosane in which the methyl groups have been oxidized to the corresponding carboxylic acids. It is the conjugate acid of a hexacosanedioate(2-). It derives from a hydride of a hexacosane.
CAT No: 10-101-322
CAS No:3365-67-1
Synonyms/Alias:Hexacosanedioic acid;3365-67-1;HEXACOSANEDIOICACID;CHEBI:76334;DTXSID70429507;LMFA01170040;SCHEMBL542366;DTXCID10380340;MFCD00673440;HY-W613967;BS-47304;E75841;Q27145891;
Hexacosanedioic Acid, also known as docosane-1,22-dioic acid, is a long-chain aliphatic dicarboxylic acid that stands out for its unique structural properties and functional versatility in research and industrial applications. Characterized by a 26-carbon backbone with terminal carboxylic acid groups, this compound exhibits excellent hydrophobicity, chemical stability, and compatibility with both organic and polymeric matrices. Its molecular architecture allows for diverse chemical modifications, making it a valuable building block in the synthesis of advanced materials and specialty chemicals. Researchers are increasingly interested in hexacosanedioic acid due to its role as a precursor in the development of functional polymers, surfactants, and as a model compound in lipid-related studies.
Polymer Synthesis: Hexacosanedioic acid is frequently employed as a monomer in the preparation of high-performance polyamides and polyesters. Its extended carbon chain imparts flexibility, durability, and enhanced hydrophobicity to the resulting polymers, which are sought after in the development of coatings, films, and engineering plastics. By reacting with various diols or diamines, it facilitates the creation of tailor-made polymers with specific thermal and mechanical properties, supporting innovation in materials science and engineering research.
Surface Modification: In surface chemistry, docosane-1,22-dioic acid serves as an effective agent for modifying the wettability and chemical resistance of substrates. When grafted onto metal, glass, or polymer surfaces, it forms dense, hydrophobic layers that improve corrosion resistance and reduce surface energy. This application is particularly valuable in the fabrication of anti-fouling coatings, protective barriers, and self-cleaning materials, enabling enhanced performance in harsh environmental conditions or demanding industrial processes.
Lipid Metabolism Research: As a structurally relevant analog of natural long-chain fatty acids, hexacosanedioic acid is utilized in biochemical studies investigating lipid metabolism, transport, and degradation pathways. Its resistance to enzymatic breakdown makes it an ideal probe for elucidating the roles of specific enzymes and transporters involved in fatty acid processing. Researchers leverage this property to better understand metabolic disorders, membrane dynamics, and the biochemistry of lipid-related cellular processes.
Nanomaterial Functionalization: The compound is increasingly used to functionalize nanoparticles and other nanostructured materials. By attaching its long-chain dicarboxylic acid moiety to nanoparticle surfaces, scientists can tune particle solubility, dispersibility, and interaction with biological or polymeric matrices. This enables the development of advanced nanocomposites, targeted delivery systems, and responsive materials with applications in catalysis, sensing, and environmental remediation.
Analytical Chemistry Standards: Hexacosanedioic acid is also valuable as a reference standard in analytical chemistry, particularly in chromatographic and spectrometric techniques. Its well-defined structure and stability make it suitable for calibrating instruments, validating analytical methods, and serving as an internal standard in the quantification of related dicarboxylic acids in complex mixtures. This application supports accurate and reproducible measurements in fields ranging from environmental monitoring to food science, ensuring data reliability and quality control in research and industrial laboratories.
3. SERS spectrum of the peptide thymosin‐β4 obtained with Ag nanorod substrate
5. Cationic cell-penetrating peptides are potent furin inhibitors
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