Invopressin presents a cyclic-like peptide framework that promotes defined molecular geometry in binding investigations. Distinct residues contribute to stability, polarity variation, and receptor-interaction modeling. The compound's behavior in solution assists studies of folding and intermolecular association. Research domains include signal-modulating peptides, sequence refinement, and structural mimicry.
CAT No: R2616
CAS No:1488411-60-4
Synonyms/Alias:Invopressin;1488411-60-4;OCE-205;Invopressina;Invopressine;invopressin [INN];GT7UX45K55;CHEMBL5314925;SCHEMBL17722524;HY-P5535;DA-64466;CS-0886345;[Phe^2,Ile^3,Dab(PhAc-D-Tyr(Me)-Phe-Gln-Asn-Ala-Pro-Arg-iGln-Lys(Ac)-Epsilon-Lys)^8]vasopressin;Glycinamide, L-cysteinyl-L-phenylalanyl-L-isoleucyl-L-glutaminyl-L-asparaginyl-L-cysteinyl-L-prolyl-(2S)-4-[[N6-(N6-acetyl-L-lysyl)-L-lysyl]amino]-2-aminobutanoyl-, cyclic (1-->6)-disulfide, (8'''-->1'')-amide with O-methyl-N-(2-phenylacetyl)-D-tyrosyl-L-phenylalanyl-L-glutaminyl-L-asparaginyl-L-alanyl-L-prolyl-L-arginyl-L-alpha-glutamine;
Invopressin, also known as arginine vasopressin or simply vasopressin, is a synthetic peptide analog that mimics the structure and function of the naturally occurring antidiuretic hormone found in mammals. Its unique molecular configuration allows it to interact with specific vasopressin receptors, making it a valuable research tool in a wide range of scientific investigations. Unlike many other peptides, Invopressin exhibits both vasoconstrictive and antidiuretic properties, enabling researchers to explore its multifaceted physiological roles. Its stability and high receptor affinity contribute to its widespread adoption in laboratory settings, where precise modulation of water balance, vascular tone, and cellular signaling pathways is required for advanced experimental designs. Researchers often utilize Invopressin in both in vitro and in vivo models to dissect complex biological systems and elucidate the mechanisms underlying water homeostasis, cardiovascular function, and neuroendocrine regulation.
Neuroscience Research: Invopressin is extensively used in neuroscience studies to investigate the central and peripheral roles of vasopressinergic signaling. By administering the compound in animal models or cell cultures, scientists can probe its effects on neuronal activity, synaptic transmission, and behavioral responses. The peptide serves as a critical tool for mapping vasopressin receptor distribution in the brain, exploring its involvement in social behaviors, learning, memory, and stress responses. Its ability to cross certain biological barriers further enhances its utility in dissecting neuroendocrine pathways and understanding the modulation of neural circuits by neuropeptides.
Renal Physiology Studies: In the field of renal research, arginine vasopressin is indispensable for examining the mechanisms of water reabsorption and osmoregulation. Researchers use it to simulate antidiuretic hormone activity in kidney models, allowing for the detailed study of aquaporin channel regulation, collecting duct function, and the molecular basis of water retention. By manipulating its concentration, scientists can model pathological states of water imbalance such as diabetes insipidus or syndrome of inappropriate antidiuretic hormone secretion, thereby gaining insights into renal adaptation and dysfunction.
Cardiovascular Research: Vasopressin analogs like Invopressin play a pivotal role in cardiovascular research. Its potent vasoconstrictive action is harnessed to study vascular smooth muscle contraction, blood pressure regulation, and the interplay between vasopressin and other vasoactive agents. In experimental models, it enables the assessment of hemodynamic responses, the investigation of receptor subtype specificity, and the elucidation of compensatory mechanisms in vascular tone regulation. These studies are fundamental for advancing the understanding of cardiovascular homeostasis and the development of novel therapeutic strategies targeting vasopressin pathways.
Endocrinology and Metabolic Studies: Researchers in the field of endocrinology utilize Invopressin to explore its regulatory effects on hormone secretion and metabolic processes. Its interaction with pituitary and adrenal axes is of particular interest in studies focused on stress response, hormone feedback loops, and metabolic adaptation. By modulating the activity of key endocrine tissues, the peptide enables the dissection of signaling cascades that govern glucose metabolism, lipid mobilization, and energy balance, thereby contributing to a deeper understanding of metabolic regulation at the molecular and systemic levels.
Cell Signaling and Receptor Pharmacology: The study of cell signaling pathways and receptor pharmacology greatly benefits from the use of vasopressin analogs. Researchers employ Invopressin to activate or inhibit specific G protein-coupled receptors, facilitating the mapping of downstream signaling events such as cAMP production, calcium mobilization, and kinase activation. These investigations are essential for characterizing receptor subtypes, understanding ligand-receptor interactions, and identifying potential targets for drug development. The compound's defined mechanism of action and receptor selectivity make it a reliable standard in pharmacological assays and receptor binding studies.
Behavioral and Social Science Research: Beyond its physiological applications, arginine vasopressin is increasingly recognized for its influence on social and behavioral processes. Scientists utilize it in experimental models to assess its impact on social recognition, pair bonding, aggression, and affiliative behaviors. By manipulating vasopressin signaling, researchers can delineate the neurobiological underpinnings of complex social interactions and investigate the genetic and environmental factors that modulate these behaviors. This line of research holds promise for advancing the understanding of social cognition and the neural basis of social disorders, highlighting the expansive utility of Invopressin in contemporary scientific inquiry.
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