Invopressin presents a cyclic-like peptide framework that promotes defined molecular geometry in binding investigations. Distinct residues contribute to stability, polarity variation, and receptor-interaction modeling. The compound's behavior in solution assists studies of folding and intermolecular association. Research domains include signal-modulating peptides, sequence refinement, and structural mimicry.
CAT No: R2616
CAS No:1488411-60-4
Synonyms/Alias:Invopressin;1488411-60-4;OCE-205;Invopressina;Invopressine;invopressin [INN];GT7UX45K55;CHEMBL5314925;SCHEMBL17722524;HY-P5535;DA-64466;CS-0886345;[Phe^2,Ile^3,Dab(PhAc-D-Tyr(Me)-Phe-Gln-Asn-Ala-Pro-Arg-iGln-Lys(Ac)-Epsilon-Lys)^8]vasopressin;Glycinamide, L-cysteinyl-L-phenylalanyl-L-isoleucyl-L-glutaminyl-L-asparaginyl-L-cysteinyl-L-prolyl-(2S)-4-[[N6-(N6-acetyl-L-lysyl)-L-lysyl]amino]-2-aminobutanoyl-, cyclic (1-->6)-disulfide, (8'''-->1'')-amide with O-methyl-N-(2-phenylacetyl)-D-tyrosyl-L-phenylalanyl-L-glutaminyl-L-asparaginyl-L-alanyl-L-prolyl-L-arginyl-L-alpha-glutamine;
Invopressin is a synthetic peptide analog structurally related to vasopressin, a well-characterized neurohypophyseal hormone. As a nonapeptide, Invopressin is engineered to mimic or modulate the biological activity of endogenous vasopressin, particularly in the context of receptor selectivity and functional potency. Its defined sequence and robust peptide backbone render it a valuable molecular tool for probing vasopressin-mediated signaling pathways, receptor pharmacology, and peptide-based regulatory mechanisms in diverse biochemical systems. Researchers in molecular biology, pharmacology, and peptide chemistry frequently leverage Invopressin to dissect the nuanced roles of vasopressin analogs in both fundamental and applied research contexts.
Receptor Binding Studies: Invopressin is widely utilized in receptor binding assays to investigate the interaction dynamics between vasopressin analogs and their cognate receptors, including V1a, V1b, and V2 subtypes. By employing radioligand binding or fluorescence-based displacement assays, scientists can quantify the affinity and selectivity of Invopressin for different vasopressin receptors. These studies are instrumental in elucidating receptor-ligand specificity, mapping receptor distribution, and characterizing allosteric modulation, thereby supporting the development of novel peptide ligands with tailored pharmacological profiles.
Signal Transduction Research: In cellular and molecular studies, Invopressin serves as a functional agonist or antagonist to stimulate or inhibit vasopressin receptor-mediated signaling cascades. Its application enables the controlled activation of G protein-coupled receptor pathways, facilitating the analysis of downstream effectors such as phospholipase C, adenylyl cyclase, and intracellular calcium mobilization. Such investigations are critical for understanding the molecular mechanisms underlying hormone action, second messenger systems, and the integration of neuroendocrine signals in target cells.
Peptide Structure-Activity Relationship (SAR) Analysis: Invopressin provides a model system for structure-activity relationship studies aimed at deciphering the impact of specific amino acid substitutions or backbone modifications on biological function. By comparing its activity profile to that of native vasopressin and other analogs, researchers can identify structural motifs responsible for receptor binding, activation, and selectivity. These insights inform rational peptide design, optimization of analogs for research applications, and the advancement of peptide-based probe development.
Pharmacological Profiling: The compound is frequently employed in in vitro and ex vivo pharmacological assays to evaluate its efficacy, potency, and desensitization kinetics across different biological systems. Through dose-response analysis, competitive inhibition studies, and functional readouts such as contractility or secretion assays, Invopressin facilitates the detailed characterization of vasopressinergic modulation. Such data are essential for benchmarking analog performance and for comparative studies with other peptide ligands.
Peptide Synthesis and Analytical Reference: Invopressin is also valuable as a reference standard in peptide synthesis workflows and analytical validation protocols. Its well-defined sequence and physicochemical properties make it suitable for calibrating chromatographic methods, verifying peptide purity, and benchmarking synthetic efficiency. Analytical laboratories and peptide chemists rely on such reference peptides to ensure the accuracy and reproducibility of synthesis and quality control processes, thereby supporting rigorous standards in peptide research and production.
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